研究内容

晶析分野
　私たちの生活に不可欠な医薬品、食品、さらには実験に用いられる化学薬品の多くは、粉末として流通しており、その大半が結晶です。しかし、一口に結晶と言っても、すべてが同じ形や構造をしているわけではありません。結晶構造が変わると溶解度や溶解速度が大きく異なり、医薬品では効き目や安定性に影響を及ぼすこともあります。当研究室では、晶析の基盤技術を発展させることを目的として、ペプチド、オリゴ糖、リン脂質、核酸化合物など多様なバイオプロダクトの結晶製造に関する研究を行っています。
バイオマス分野
　再生可能エネルギーの有効活用を図るため、当研究室では木質系バイオマスの水熱分解に関する研究を行っています。木質系バイオマスに含まれるセルロースやヘミセルロースはバイオエタノールの原料となりますが、もう一つの主要成分であるリグニンの利用法は十分に確立されていません。リグニンは石油に代わる新たな化学原料となり得る重要物質であり、当研究室ではその高効率な分解法と有効利用の方法について研究を進めています。

Crystallization of Four Troglitazone Isomers: Selectivity and Structural Considerations
S. Matsuura, K. Igarashi*, M. Azuma, H. Ooshima
Crystals, 15(10), 866, 2025

Continuous Sonocrystallization Process for Controlling the Polymorphs and Particle Size of Perampanel
K. Machida, K. Igarashi, H. Kawachi, M. Okamoto, S. Yonezawa, Y. Morishige, M. Azuma, A. Nishiyama
Org. Process Res. Dev., 28, 4003-4010, 2024

The Solid-Phase Transition of Carbapenem CS-023 Polymorphs and the Change in Helicity Observed in the Transition
S. Matsuura, K. Igarashi, M. Azuma, H. Ooshima
Crystals, 14(1), 71, 2024

Efficient optical resolution of DL-glutamate by combining enzymatic racemization
K. Igarashi, T. Fujimura
Journal of Chemical Engineering of Japan, 56(1), 2023

Polymorphic crystallization design to prevent the degradation of the β-lactam structure of a carbapenem
S. Matsuura, K. Igarashi, M. Azuma, H. Ooshima
Crystals, 11(8), 2021

Simultaneous Control of Crystal Habit and Particle Size of Ecabet Sodium Hydrate with Rapid Cooling Crystallization and Temperature Cycling
M. Kishida, K. Igarashi, M. Azuma, H. Ooshima
Journal of Chemical Engineering of Japan, 52(5), 455-464, 2019

Pharmaceutical Microcrystal Formation by Supersaturation Control with an Electrolyte
M. Kishida, K. Igarashi, M. Azuma, H. Ooshima
Journal of Chemical Engineering of Japan, 51(7), 1-6, 2018

Behavior of t-butoxycarbonyl-L-asparagine (Boc-Asn) on the initial stage of crystallization
K. Igarashi*, M. Aoki, Y. Masuda, M. Azuma, H. Ooshima
Journal of Chemical Engineering of Japan, 50(1), 111-115, 2018

Localized Solvent Effects on the Crystal Habit of tert-Butoxycarbonyl-L-asparagine (Boc-Asn)
M. Hirano, K. Igarashi, H. Ooshima
Journal of Chemical Engineering of Japan, 50, 207-212, 2017

Cooling Crystallization Using a mL-Scale Continuous Crystallizer Equipped with a High Speed Agitator for Production of Uniform Small Crystals
K. Igarashi, H. Ooshima
Journal of Chemical Engineering of Japan, 49, 805-808, 2016

Crystallization Behavior of Ibuprofen under the Microwave Irradiation
K. Igarashi, S. Kihara, H. Ooshima
Journal of Chemical Engineering of Japan, 46(12), 797-801, 2013

Structure of supersaturated solution and crystal nucleation induced by diffusion
H. Ooshima, K. Igarashi, H. Iwasa, R. Yamamoto
Journal of Crystal Growth, 373, 2-6, 2013

Repeated Cooling Crystallization for Production of Microcrystals with a Narrow Size Distribution
Z. Xing, K. Igarashi, A. Morioka, H. Ooshima
Journal of Chemical Engineering of Japan, 45(10), 811-815, 2012

Control of Crystal Size Distribution Using a mL-Scale Continuous Crystallizer Equipped with a High Speed Agitator
K. Igarashi, Y. Yamanaka, M. Azuma, H. Ooshima
Journal of Chemical Engineering of Japan, 45(1), 28-33, 2012

Relationship between Crystal Polymorphism and Solution Structure of an Imidazopyridine Derivative Developed as a Drug Substance for Osteoporosis
M. Hirano, K. Igarashi, K. Machiya, R. Tamura, H. Tue, H. Ooshima
Journal of Chemical Engineering of Japan, 42(3), 204-211, 2009

Synthesis and degradation of acyl peptide using enzyme from Pseudomonas aeruginosa
N. N. Islam, K. Igarashi, T. Tachibana, H. Ooshima, M. Azuma
Journal of Bioscience and Bioengineering, 105(3), 282-287, 2008

Growth mechanism of Calcium Carbonate Tubes on a Cation-exchange Membrane
K. Igarashi, M. Takiguchi, H. Ooshima
Journal of the Ceramic Society of Japan, 116(1), 111-114, 2008

Saccharomyces cerevisiae mutant displaying beta-glucans on cell surface
Y. Sakai, M. Azuma, Y. Takada, T. Umeyama, A. Kaneko, T. Fujita, K. Igarashi, H. Ooshima
Journal of Bioscience and Bioengineering, 103(2), 161-166, 2007

Purification and Characterization of Enzyme Responsible for N-Myristoylation of Octapeptide in Aqueous Solution without ATP and Coenzyme A from Pseudomonas aeruginosa
T. Jyomoto, M. Azuma, N. N. Islam, R. Fujinami, T. Takao, T. Ogawa, M. Tabuchi, K. Igarashi, J. Kato, H. Ooshima
Journal of Bioscience and Bioengineering, 102(3), 193-197, 2006

Flowerlike Agglomerates of Calcium Carbonate Crystals Formed on an Eggshell Membrane
M. Takiguchi, K. Igarashi, M. Azuma, H. Ooshima
Crystal Growth & Design, 6(12), 2754-2757, 2006

Studies on the hydration of Aerosol OT and the formation of reversed micelles in decane by calorimetry and ab initio calculation
K. Sameshima, R. Tanaka, K. Igarashi, H. Ooshima
Journal of Chemical Thermodynamics, 38, 662-671, 2006

Relationship between Cell Morphology and Intracellular Potassium Concentration in Candida albicans
H. Watanabe, M. Azuma, K. Igarashi, H. Ooshima
Journal of Antibiotics, 59(5), 281-287, 2006

Tubular Structure Agglomerates of Calcium Carbonate Crystals Formed on a Cation-Exchange Membrane
M. Takiguchi, K. Igarashi, M. Azuma, H. Ooshima
Crystal Growth & Design, 6(7), 1611-1614, 2006

Crystallization of β-Sitosterol Using a Water-Immiscible Solvent Hexane
H. Kawachi, R. Tanaka, M. Hirano, K. Igarashi, H. Ooshima
Journal of Chemical Engineering of Japan, 39, 869-875, 2006

Manipulation of morphological transition in Saccharomyces cerevisiae mutant J19
M. Maneesri, M. Azuma, K. Igarashi, A. Sugihara, H. Ooshima
Biochemical Engineering Journal, 27, 72-76, 2005

Deletion of MCD4 involved in GPI anchor synthesis leads to increased beta-1,6-glucan level and decreased GPI-anchored protein and mannan levels in Saccharomyces cerevisiae
M. Maneesri, M. Azuma, Y. Sakai, K. Igarashi, T. Matsumoto, H. Fukuda, A. Kondo, H. Ooshima
Journal of Bioscience and Bioengineering, 99, 354-360, 2005

Valinomycin Affects the Morphology of Candida albicans
H. Watanabe, M. Azuma, K. Igarashi, H. Ooshima
Journal of Antibiotics, 58(12), 753-758, 2005

The Effects of Impurities on Crystallization of Polymorphs of a Drug Substance AE1-923
M. Okamoto, M. Hamano, K. Igarashi, H. Ooshima
Journal of Chemical Engineering of Japan, 37(10), 1224-1231, 2004

Effects of a solute analogue p-acetoacetanisidide on the crystallization of p-acetanisidide
A. Saito, K. Igarashi, M. Azuma, H. Ooshima
Journal of Chemical Engineering of Japan, 36, 953-958, 2003

Control of Polymorphs on the Crystallization of Glycine Using WWDJ Batch Crystallizer
K. Igarashi, Y. Sasaki, M. Azuma, H. Noda, H. Ooshima
Engineering in Life Sciences, 3, 159-163, 2003

Characterization of a Saccharomyces cerevisiae Mutant with Pseudohyphae and Cloning of a Gene Complementing the Mutation
J. Maneesri, M. Azuma, S. Torii, K. Igarashi, H. Ooshima
Bioscience, Biotechnology, and Biochemistry, 67(3), 517-524, 2003

Production of Large Crystals of Glycine with a Narrow Size Distribution Using WWDJ-Batch Crystallizer
H. Ooshima, K. Igarashi, Y. Sasaki, M. Azuma, H. Noda
Chemical Engineering Transactions, 1, 981-986, 2002

Control of Polymorphs on the Crystallization of Glycine Using WWDJ Batch Crystallizer
K. Igarashi, Y. Sasaki, M. Azuma, H. Noda, H. Ooshima
Chemical Engineering Transactions, 1, 683-688, 2002

Aggregation of p-Acetanisidide Molecules in the Under- and Supersaturated Solution and Its Effect on Crystallization
A. Saito, K. Igarashi, M. Azuma, H. Ooshima
Journal of Chemical Engineering of Japan, 35, 1133-1139, 2002

Dissolution kinetics of crystals in suspension and its application to L-aspartic acid crystals
S. Gu, K. Igarashi, H. Ooshima
Chemical Engineering Journal, 88, 53-58, 2002

Production of large crystals with a narrow crystal size distribution by a novel WWDJ batch crystallizer
S. Gu, K. Igarashi, H. Noda, H. Ooshima
Chemical Engineering Journal, 85, 161-167, 2002

Control of solvent-mediated transformation of crystal polymorphs using a newly developed batch crystallizer (WWDJ-crystallizer)
S. Gu, K. Igarashi, H. Noda, H. Ooshima
Chemical Engineering Journal, 85, 169-176, 2002

Light intensity distribution in an externally illuminated cylindrical photobioreactor and its application to hydrogen production by Rhodobacter capsulatus
T. Katsuda, T. Arimoto, K. Igarashi, M. Azuma, J. Kato, S. Takakuwa, H. Ooshima
Biochemical Engineering Journal, 5, 157-164, 2000

Removal of Cadmium Ion by P. flexuosa
M. Azuma, A. Oobayashi, M. Kondoh, C. Kawasaki, K. Igarashi, J. Kato, H. Ooshima
Bioseparation Engineering, -, 175-180, 2000

The initial stage of crystallization of lysozyme: a DSC study
K. Igarashi, M. Azuma, J. Kato, H. Ooshima
Journal of Crystal Growth, 204, 191-200, 1999

Mechanism of Crystal Growth of Protein: DSC of Thermolysin Crystal Suspension
H. Ooshima, S. Urabe, K. Igarashi, M. Azuma, J. Kato
ACS Symposium Series, 667, 18-27, 1997