Research

Research

「メスの技」だけで癌が治るなら
レジェンド達の時代にとっくに根絶されているはず。
病巣に直達し取り除く「手術」がもっと活躍できる、
新しい治療戦略が求められています。
癌治療は, 世界中の医師・研究者・企業関係者が
それぞれの得意技を発揮する、壮大な分業です。

Research

OMU HBPsが特に注力する研究テーマ RESEARCH THEME

  1. ❶. 蛍光イメージングを活用した新規術中診断法・癌治療法の開発
  2. ❷. 「低侵襲手術」の枠を超えた手術ダメージの低減
  3. ❸. 腸内細菌叢が発癌と術後免疫に及ぼす影響の解明
  4. ❹. AIとロボットを活用した外科治療戦略の構築
  5. ❺. 癌微小環境を保持したPDXモデルの構築と治療応用
  6. ❻. 胆道癌に対する個別化治療の実現

研究トピック紹介 INTRODUCTION TOPICS

発表 ANNOUNCEMENT

欧文論文
(2023年)

Tanaka S, Noda T, Komeda K, Kosaka H, Iida H, Ueno M, Hokuto D, Ikoma H, Nakai T, Kabata D, Shinkawa H, Kobayashi S, Hirokawa F, Mori H, Hayami S, Morimura R, Matsumoto M, Ishizawa T, Kubo S, Kaibori M. Surgical Outcomes for Hepatocellular Carcinoma in Patients with Child-Pugh Class B: a Retrospective Multicenter Study. J Gastrointest Surg. 2023 Feb;27(2):283-295. doi:10.1007/s11605-022-05549-w. Epub 2022 Dec 5. PMID: 36471191.

Nishio K, Kimura K, Murata A, Ohira G, Shinkawa H, Kodai S, Amano R, Tanaka S, Shimizu S, Takemura S, Kanazawa A, Kubo S, Ishizawa T. Comparison of clinicopathological characteristics between resected ampullary carcinoma and carcinoma of the second portion of the duodenum. World J Gastrointest Surg. 2022 Nov 27;14(11):1219-1229. doi: 10.4240/wjgs.v14.i11.1219. PMID: 36504514; PMCID: PMC9727577.

Tanaka S, Kubo S, Ishizawa T. Positioning of Minimally Invasive Liver Surgery for Hepatocellular Carcinoma: From Laparoscopic to Robot-Assisted Liver Resection. Cancers (Basel). 2023 Jan 12;15(2):488. doi: 10.3390/cancers15020488. PMID: 36672437; PMCID: PMC9856586.

Kubo S, Tanaka S, Kinoshita M, Shinkawa H, Ishizawa T, Sato Y. Development of intraductal papillary neoplasm of the bile duct in patients with occupational cholangiocarcinoma. Virchows Arch. 2023 Apr;482(4):745-753. doi: 10.1007/s00428-023-03499-5. Epub 2023 Jan 30. PMID: 36715769.

de Muynck LDAN, White KP, Alseidi A, Bannone E, Boni L, Bouvet M, Falconi M, Fuchs HF, Ghadimi M, Gockel I, Hackert T, Ishizawa T, Kang CM, Kokudo N, Nickel F, Partelli S, Rangelova E, Swijnenburg RJ, Dip F, Rosenthal RJ, Vahrmeijer AL, Mieog JSD. Consensus Statement on the Use of Near-Infrared Fluorescence Imaging during Pancreatic Cancer Surgery Based on a Delphi Study: Surgeons' Perspectives on Current Use and Future Recommendations. Cancers (Basel). 2023 Jan 20;15(3):652. doi: 10.3390/cancers15030652. PMID: 36765609; PMCID: PMC9913161.

Kinoshita M, Ueda D, Matsumoto T, Shinkawa H, Yamamoto A, Shiba M, Okada T, Tani N, Tanaka S, Kimura K, Ohira G, Nishio K, Tauchi J, Kubo S, Ishizawa T. Deep Learning Model Based on Contrast-Enhanced Computed Tomography Imaging to Predict Postoperative Early Recurrence after the Curative Resection of a Solitary Hepatocellular Carcinoma. Cancers (Basel). 2023 Apr 4;15(7):2140. doi: 10.3390/cancers15072140. PMID: 37046801; PMCID: PMC10092973.

Kimura K, Amano R, Tauchi J, Nishio K, Ohira G, Shinkawa H, Tanaka S, Yamamoto A, Motomura H, Ishizawa T. Pancreaticoduodenectomy with celiac artery resection (PD-CAR) for unresctable locally advanced pancreatic ductal adenocarcinoma. Langenbecks Arch Surg. 2023 May 4;408(1):174. doi: 10.1007/s00423-023-02860-1. PMID: 37140679.

Kubo S, Shinkawa H, Tanaka S, Kimura K, Ohira G, Nishio K, Kinoshita M, Tauchi J, Shirai D, Okada T, Tani N, Ishizawa T. Efficacy and safety of tazobactam/ceftolozane in combination with metronidazole for intraabdominal infection in a hepato-biliary-pancreatic field in clinical practice. J Infect Chemother. 2023 Sep;29(9):895-899. doi: 10.1016/j.jiac.2023.06.002. Epub 2023 Jun 3. PMID: 37276996.

Okada T, Tanaka S, Shinkawa H, Ohira G, Kinoshita M, Amano R, Kimura K, Nishio K, Tauchi J, Uchida-Kobayashi S, Fujii H, Ishizawa T. Impact of frailty on long-term outcomes after liver resection for hepatocellular carcinoma in elderly patients: A prospective study. Asian J Surg. 2024 Jan;47(1):147-153. doi: 10.1016/j.asjsur.2023.05.139. Epub 2023 Jun 10. PMID: 37302885.

Mitsuyama Y, Kageyama K, Shinkawa H, Yamamoto A, Jogo A, Sohgawa E, Tanaka S, Takemura S, Kubo S, Ishizawa T, Miki Y. Atezolizumab plus bevacizumab-induced intratumoral hemorrhage in a patient with rib metastasis from unresectable hepatocellular carcinoma. Radiol Case Rep. 2023 Jun 21;18(9):3037-3040. doi: 10.1016/j.radcr.2023.06.012. PMID: 37434611; PMCID: PMC10331133.

Kinoshita M, Kawaguchi T, Tanaka S, Kimura K, Shinkawa H, Ohira G, Nishio K, Tanaka R, Kurihara S, Kushiyama S, Ishizawa T. Application of Indocyanine Green Fluorescence Imaging for Tumor Localization during Robot-Assisted Hepatectomy. Cancers (Basel). 2023 Aug 22;15(17):4205. doi: 10.3390/cancers15174205. PMID: 37686481; PMCID: PMC10487047.

Takahashi R, Ishizawa T, Inagaki Y, Tanaka M, Ogasawara A, Kuriki Y, Fujita K, Kamiya M, Ushiku T, Urano Y, Hasegawa K. Real-Time Fluorescence Imaging to Identify Cholangiocarcinoma in the Extrahepatic Biliary Tree Using an Enzyme- Activatable Probe. Liver Cancer. 2023 Apr 14;12(6):590-602. doi: 10.1159/000530645. PMID: 38058421; PMCID: PMC10697719.

      
      
(2022年)

Kudo M, Izumi N, Kokudo N, Sakamoto M, Shiina S, Takayama T, Tateishi R, Nakashima O, Murakami T, Matsuyama Y, Takahashi A, Miyata H, Kubo S. Report of the 22nd nationwide follow-up Survey of Primary Liver Cancer in Japan (2012-2013). Hepatol Res. 2022 Jan;52(1):5-66. doi: 10.1111/hepr.13675. Epub 2022 Jan 2. PMID: 34050584.

Nishio K, Kimura K, Eguchi S, Shirai D, Tauchi J, Kinoshita M, Murata A, Ohira G, Shinkawa H, Shintaro K, Amano R, Tanaka S, Shimizu S, Takemura S, Kanazawa A, Kubo S. Prognostic Factors and Lymph Node Metastasis Patterns of Primary Duodenal Cancer. World J Surg. 2022 Jan;46(1):163-171. doi: 10.1007/s00268-021-06339-2. Epub 2021 Oct 19. PMID: 34668046.

Tanaka S, Iida H, Ueno M, Hirokawa F, Yoshida H, Ishii H, Nomi T, Nakai T, Kaibori M, Ikoma H, Noda T, Shinkawa H, Maehira H, Hayami S, Komeda K, Kubo S. Postoperative loss of independence 1 year after liver resection: prospective multicentre study. Br J Surg. 2022 Feb 24;109(3):e54-e55. doi: 10.1093/bjs/znab452. PMID: 35041737.

Tanaka R, Kimura K, Eguchi S, Ohira G, Tanaka S, Amano R, Tanaka H, Yashiro M, Ohira M, Kubo S. Interleukin-8 produced from cancer-associated fibroblasts suppresses proliferation of the OCUCh-LM1 cancer cell line. BMC Cancer. 2022 Jul 8;22(1):748. doi: 10.1186/s12885-022-09847-z. PMID: 35804329; PMCID: PMC9270823.

Tanaka S, Umemoto K, Kubo S, Sato Y, Mimaki S, Tsuchihara K, Takemura S, Shinkawa H, Mori A, Ikeda M. Nivolumab for treating patients with occupational cholangiocarcinoma. J Hepatobiliary Pancreat Sci. 2022 Nov;29(11):1153-1155. doi: 10.1002/jhbp.1215. Epub 2022 Aug 8. PMID: 35793385.

Tanaka S, Noda T, Komeda K, Kosaka H, Iida H, Ueno M, Hokuto D, Ikoma H, Nakai T, Kabata D, Shinkawa H, Kobayashi S, Hirokawa F, Mori H, Hayami S, Morimura R, Matsumoto M, Ishizawa T, Kubo S, Kaibori M. Surgical Outcomes for Hepatocellular Carcinoma in Patients with Child-Pugh Class B: a Retrospective Multicenter Study. J Gastrointest Surg. 2023 Feb;27(2):283-295. doi: 10.1007/s11605-022-05549-w. Epub 2022 Dec 5. PMID: 36471191.

Hirokawa F, Ueno M, Nakai T, Kaibori M, Nomi T, Iida H, Tanaka S, Komeda K, Hayami S, Kosaka H, Hokuto D, Kubo S, Uchiyama K. Treatment strategy for resectable colorectal cancer liver metastases from the viewpoint of time to surgical failure. Langenbecks Arch Surg. 2022 Mar;407(2):699-706. doi: 10.1007/s00423-021-02372-w. Epub 2021 Nov 6. PMID: 34741671.

Hirokawa F, Ueno M, Nakai T, Kaibori M, Nomi T, Iida H, Tanaka S, Komeda K, Hayami S, Kosaka H, Hokuto D, Kubo S, Uchiyama K. Neoadjuvant Chemotherapy Versus Upfront Surgery for Resectable Liver Metastases from Colorectal Cancer: a Multicenter, Propensity Score-Matched Cohort Study. J Gastrointest Surg. 2022 Apr;26(4):772-781. doi: 10.1007/s11605-021-05175-y. Epub 2021 Oct 18. PMID: 34664190.

Iida H, Tani M, Komeda K, Nomi T, Matsushima H, Tanaka S, Ueno M, Nakai T, Maehira H, Mori H, Matsui K, Hirokawa F, Kaibori M, Kubo S. Superiority of CRP-albumin-lymphocyte index (CALLY index) as a non-invasive prognostic biomarker after hepatectomy for hepatocellular carcinoma. HPB (Oxford). 2022 Jan;24(1):101-115. doi: 10.1016/j.hpb.2021.06.414. Epub 2021 Jun 22. PMID: 34244053.

Kawamura E, Matsubara T, Daikoku A, Deguchi S, Kinoshita M, Yuasa H, Urushima H, Odagiri N, Motoyama H, Kotani K, Kozuka R, Hagihara A, Fujii H, Uchida-Kobayashi S, Tanaka S, Takemura S, Iwaisako K, Enomoto M, Taguchi YH, Tamori A, Kubo S, Ikeda K, Kawada N. Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21. FEBS Open Bio. 2022 Dec;12(12):2122-2135. doi: 10.1002/2211-5463.13489. Epub 2022 Sep 26. PMID: 36114826; PMCID: PMC9714377.

Morise Z, Aldrighetti L, Belli G, Ratti F, Cheung TT, Lo CM, Tanaka S, Kubo S, Okamura Y, Uesaka K, Monden K, Sadamori H, Hashida K, Kawamoto K, Gotohda N, Chen K, Kanazawa A, Takeda Y, Ohmura Y, Ueno M, Ogura T, Suh KS, Kato Y, Sugioka A, Belli A, Nitta H, Yasunaga M, Cherqui D, Halim NA, Laurent A, Kaneko H, Otsuka Y, Kim KH, Cho HD, Lin CC, Ome Y, Seyama Y, Troisi RI, Berardi G, Rotellar F, Wilson GC, Geller DA, Soubrane O, Yoh T, Kaizu T, Kumamoto Y, Han HS, Ekmekcigil E, Dagher I, Fuks D, Gayet B, Buell JF, Ciria R, Briceno J, O'Rourke N, Lewin J, Edwin B, Shinoda M, Abe Y, Hilal MA, Alzoubi M, Tanabe M, Wakabayashi G. An International Retrospective Observational Study of Liver Functional Deterioration after Repeat Liver Resection for Patients with Hepatocellular Carcinoma. Cancers (Basel). 2022 May 24;14(11):2598. doi: 10.3390/cancers14112598. PMID: 35681578; PMCID: PMC9179920.

Uchida-Kobayashi S, Kageyama K, Takemura S, Matsumoto K, Odagiri N, Jogo A, Kotani K, Kozuka R, Motoyama H, Kawamura E, Hagihara A, Yamamoto A, Fujii H, Tanaka S, Enomoto M, Tamori A, Miki Y, Kubo S, Kawada N. Efficacy of rechallenge transcatheter arterial chemoembolization after lenvatinib treatment for advanced hepatocellular carcinoma. JGH Open. 2022 Sep 21;6(11):754-762. doi: 10.1002/jgh3.12819. PMID: 36406645; PMCID: PMC9667401.

Aota T, Tanaka S, Takemura S, Amano R, Kimura K, Shinkawa H, Ohira G, Nishio K, Ishizawa T, Kubo S. Development of gallbladder cancer during follow-up of pancreaticobiliary maljunction: a report of two cases. J Surg Case Rep. 2022 Dec 30;2022(12):rjac595. doi: 10.1093/jscr/rjac595. PMID: 36601101; PMCID: PMC9803975.

Yoshikawa-Kimura A, Taira K, Maruyama H, Ishikawa-Kakiya Y, Yamamura M, Tanoue K, Hagihara A, Uchida-Kobayashi S, Enomoto M, Kimura K, Tanaka S, Amano R, Takemura S, Ohfuji S, Tanaka F, Nagami Y, Fujiwara Y. Influence of a biliary stent in patients with advanced pancreatic cancer treated with modified FOLFIRINOX. Medicine (Baltimore). 2022 Dec 9;101(49):e32150. doi: 10.1097/MD.0000000000032150. PMID: 36626539; PMCID: PMC9750610.

Matsui T, Hamada-Tsutsumi S, Naito Y, Nojima M, Iio E, Tamori A, Kubo S, Ide T, Kondo Y, Eguchi Y, Komori A, Morine Y, Shimada M, Utsunomiya T, Shirabe K, Kimura K, Hiasa Y, Chuaypen N, Tangkijvanich P, Naiki-Ito A, Takahashi S, Ochiya T, Tanaka Y. Identification of microRNA-96-5p as a postoperative, prognostic microRNA predictor in nonviral hepatocellular carcinoma. Hepatol Res. 2022 Jan;52(1):93-104. doi: 10.1111/hepr.13674. Epub 2021 Jun 14. PMID: 34038612.

Shinkawa H, Hirokawa F, Kaibori M, Kabata D, Nomi T, Ueno M, Ikoma H, Nakai T, Iida H, Tanaka S, Komeda K, Kosaka H, Hokuto D, Hayami S, Morimura R, Matsumoto M, Maehira H, Takemura S, Kubo S. Impact of laparoscopic parenchyma-sparing resection of lesions in the right posterosuperior liver segments on surgical outcomes: A multicenter study based on propensity score analysis. Surgery. 2022 May;171(5):1311-1319. doi: 10.1016/j.surg.2021.09.021. Epub 2021 Dec 7. PMID: 34887090.

Shinkawa H, Kubo S, Mikamo H, Matsuda N, Omura K, Okamoto K, Ono S, Obara H, Kobayashi M, Sasaki J, Shimizu J, Sueyoshi S, Yoshida J, Watanabe M, Takesue Y. Survey on the current status of the indication and implementation protocols for bile replacement in patients with external biliary drainage with special reference to infection control. Surg Today. 2022 Oct;52(10):1446-1452. doi: 10.1007/s00595-022-02475-x. Epub 2022 Feb 19. PMID: 35182252.

Shinkawa H, Hirokawa F, Kaibori M, Nomi T, Ueno M, Ikoma H, Nakai T, Iida H, Tanaka S, Komeda K, Kosaka H, Hokuto D, Hayami S, Morimura R, Matsumoto M, Maehira H, Takemura S, Kubo S. Risk factors for and management of morbidity in pure laparoscopic resection of the right posterosuperior segments of the liver: A multicenter retrospective study. Asian J Endosc Surg. 2022 Jul;15(3):539-546. doi: 10.1111/ases.13042. Epub 2022 Feb 15. PMID: 35170224.

Eguchi S, Kimura K, Kageyama K, Tani N, Tanaka R, Nishio K, Shinkawa H, Ohira GO, Amano R, Tanaka S, Yamamoto A, Takemura S, Yashiro M, Kubo S. Optimal Organ for Patient-derived Xenograft Model in Pancreatic Cancer and Microenvironment that Contributes to Success. Anticancer Res. 2022 May;42(5):2395-2404. doi: 10.21873/anticanres.15718. PMID: 35489770.

Kinoshita M, Tanaka S, Kodai S, Takemura S, Shinkawa H, Ohira G, Nishio K, Tauchi J, Kanazawa A, Kubo S. Increasing incidence and severity of post-hepatectomy adhesion around the liver may be influenced by the hepatectomy-related operative procedures. Asian J Surg. 2023 Jan;46(1):228-235. doi: 10.1016/j.asjsur.2022.03.044. Epub 2022 Mar 29. PMID: 35365391.

Hoang DV, Thuy LTT, Hai H, Hieu VN, Kimura K, Oikawa D, Ikura Y, Dat NQ, Hoang TH, Sato-Matsubara M, Dong MP, Hanh NV, Uchida-Kobayashi S, Tokunaga F, Kubo S, Ohtani N, Yoshizato K, Kawada N. Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species. Oncogenesis. 2022 May 3;11(1):23. doi: 10.1038/s41389-022-00389-4. PMID: 35504863; PMCID: PMC9065067.

Kubo S, Nagano H, Tsujie M, Seo S, Gotoh K, Wada H, Nakashima S, Ioka T. Microsatellite instability in patients with hepato-biliary-pancreatic malignancies in clinical practice (KHBO 1903). Int J Clin Oncol. 2022 Aug;27(8):1340-1347. doi: 10.1007/s10147-022-02187-9. Epub 2022 Jun 19. PMID: 35718824.

Okushin K, Tateishi R, Takahashi A, Uchino K, Nakagomi R, Nakatsuka T, Minami T, Sato M, Fujishiro M, Hasegawa K, Eguchi Y, Kanto T, Kubo S, Yoshiji H, Miyata H, Izumi N, Kudo M, Koike K. Current status of primary liver cancer and decompensated cirrhosis in Japan: launch of a nationwide registry for advanced liver diseases (REAL). J Gastroenterol. 2022 Aug;57(8):587-597. doi: 10.1007/s00535-022-01893-5. Epub 2022 Jul 5. PMID: 35788887.

Shirai D, Shinkawa H, Kabata D, Takemura S, Tanaka S, Amano R, Kimura K, Ohira G, Nishio K, Tauchi J, Kinoshita M, Kubo S. Laparoscopic liver resection reduces postoperative infection in patients with hepatocellular carcinoma: a propensity score-based analysis. Surg Endosc. 2022 Dec;36(12):9194-9203. doi: 10.1007/s00464-022-09403-7. Epub 2022 Jul 15. PMID: 35838833.

Nomi T, Kaibori M, Tanaka S, Hirokawa F, Hokuto D, Noda T, Ueno M, Nakai T, Ikoma H, Iida H, Matsui K, Komeda K, Hayami S, Eguchi H, Matsumoto M, Morimura R, Maehira H, Yoshikawa T, Kubo S. Short- and long-term outcomes of laparoscopic versus open repeat liver resection for hepatocellular carcinoma: A multicenter study. J Hepatobiliary Pancreat Sci. 2023 Mar;30(3):283-292. doi: 10.1002/jhbp.1222. Epub 2022 Aug 25. PMID: 35918904.

Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N. Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms. Sci Adv. 2022 Sep 30;8(39):eabo5525. doi: 10.1126/sciadv.abo5525. Epub 2022 Sep 28. PMID: 36170363; PMCID: PMC9519040.

Kubo S, Shinkawa H, Asaoka Y, Ioka T, Igaki H, Izumi N, Itoi T, Unno M, Ohtsuka M, Okusaka T, Kadoya M, Kudo M, Kumada T, Kokudo N, Sakamoto M, Sakamoto Y, Sakurai H, Takayama T, Nakashima O, Nagata Y, Hatano E, Harada K, Murakami T, Yamamoto M. Liver Cancer Study Group of Japan Clinical Practice Guidelines for Intrahepatic Cholangiocarcinoma. Liver Cancer. 2022 Feb 23;11(4):290-314. doi: 10.1159/000522403. PMID: 35978598; PMCID: PMC9294959.

Shirai D, Shinkawa H, Kabata D, Takemura S, Tanaka S, Amano R, Kimura K, Ohira G, Nishio K, Tauchi J, Kinoshita M, Kubo S. Laparoscopic liver resection reduces postoperative infection in patients with hepatocellular carcinoma: a propensity score-based analysis. Surg Endosc. 2022 Dec;36(12):9194-9203. doi: 10.1007/s00464-022-09403-7. Epub 2022 Jul 15. PMID: 35838833.

Groen JV, Henrar RB, Hanna Sawires RG, AlEassa E, Martini CH, Bonsing BA, Vahrmeijer AL, Besselink MG, Pecorelli N, Hackert T, Ishizawa T, Miller T, Mungroop TH, Samra J, Sauvanet A, Adham M, Demartines N, Christophi C, Morris-Stiff G, Mieog JSD. Pain management, fluid therapy and thromboprophylaxis after pancreatoduodenectomy: a worldwide survey among surgeons. HPB (Oxford). 2022 Apr;24(4):558-567. doi: 10.1016/j.hpb.2021.09.006. Epub 2021 Sep 24. PMID: 34629261.

Ishizawa T, McCulloch P, Muehrcke D, Carus T, Wiesel O, Dapri G, Schneider-Koriath S, Wexner SD, Abu-Gazala M, Boni L, Cassinotti E, Sabbagh C, Cahill R, Ris F, Carvello M, Spinelli A, Vibert E, Terasawa M, Takao M, Hasegawa K, Schols RM, Pruimboom T, Murai Y, Matano F, Bouvet M, Diana M, Kokudo N, Dip F, White K, Rosenthal RJ. Assessing the development status of intraoperative fluorescence imaging for perfusion assessments, using the IDEAL framework. BMJ Surg Interv Health Technol. 2021 Oct 19;3(1):e000088. doi: 10.1136/bmjsit-2021-000088. PMID: 35047805; PMCID: PMC8749280.

Ishizawa T, McCulloch P, Stassen L, van den Bos J, Regimbeau JM, Dembinski J, Schneider-Koriath S, Boni L, Aoki T, Nishino H, Hasegawa K, Sekine Y, Chen-Yoshikawa T, Yeung T, Berber E, Kahramangil B, Bouvet M, Diana M, Kokudo N, Dip F, White K, Rosenthal RJ. Assessing the development status of intraoperative fluorescence imaging for anatomy visualisation, using the IDEAL framework. BMJ Surg Interv Health Technol. 2022 Nov 4;4(1):e000156. doi: 10.1136/bmjsit-2022-000156. PMID: 36353184; PMCID: PMC9639126.

Ishizawa T, Akamatsu N, Kaneko J, Arita J, Hasegawa K. Closure and anastomosis of the pancreas using a four-needle three-loop suture device. Glob Health Med. 2022 Aug 31;4(4):225-229. doi: 10.35772/ghm.2022.01044. PMID: 36119788; PMCID: PMC9420325.

Dip F, Aleman J, DeBoer E, Boni L, Bouvet M, Buchs N, Carus T, Diana M, Elli EF, Hutteman M, Ishizawa T, Kokudo N, Lo Menzo E, Ludwig K, Phillips E, Regimbeau JM, Rodriguez-Zentner H, Roy MD, Schneider-Koriath S, Schols RM, Sherwinter D, Simpfendorfer C, Stassen L, Szomstein S, Vahrmeijer A, Verbeek FPR, Walsh M, White KP, Rosenthal RJ. Use of fluorescence imaging and indocyanine green during laparoscopic cholecystectomy: Results of an international Delphi survey. Surgery. 2022 Dec;172(6S):S21-S28. doi: 10.1016/j.surg.2022.07.012. PMID: 36427926.

Sherwinter DA, Boni L, Bouvet M, Ferri L, Hyung WJ, Ishizawa T, Kaleya RN, Kelly K, Kokudo N, Lanzarini E, Luyer MDP, Mitsumori N, Mueller C, Park DJ, Ribero D, Rosati R, Ruurda JP, Sosef M, Schneider-Koraith S, Spinoglio G, Strong V, Takahashi N, Takeuchi H, Wijnhoven BPL, Yang HK, Dip F, Lo Menzo E, White KP, Rosenthal RJ. Use of fluorescence imaging and indocyanine green for sentinel node mapping during gastric cancer surgery: Results of an intercontinental Delphi survey. Surgery. 2022 Dec;172(6S):S29-S37. doi: 10.1016/j.surg.2022.06.036. PMID: 36427927; PMCID: PMC9720539.

Aota T, Tanaka S, Takemura S, Amano R, Kimura K, Shinkawa H, Ohira G, Nishio K, Ishizawa T, Kubo S. Development of gallbladder cancer during follow-up of pancreaticobiliary maljunction: a report of two cases. J Surg Case Rep. 2022 Dec 30;2022(12):rjac595. doi: 10.1093/jscr/rjac595. PMID: 36601101; PMCID: PMC9803975.

和文著書・論文
(2023年)

新川 寛二, 田中 肖吾, 天野 良亮, 木村 健二郎, 大平 豪, 西尾 康平, 木下 正彦, 田内 潤, 白井 大介, 岡田 拓真, 谷 直樹 川口 貴士 石沢 武彰. 誌上ディベート(第37回) intermediate HCCに対する治療戦略 手術first vs.非手術first 手術firstの立場から. 消化器外科 46(1) 90-93 2023年1月

田中 肖吾, 久保 正二, 石沢 武彰. 【外科医が知っておくべき! 免疫チェックポイント阻害薬】症例紹介 職業性胆管癌再発に対しニボルマブで完全寛解後長期間durable responseが認められた1例. 臨床外科 78(1) 74-82 2023年1月

木下 正彦, 新川 寛二, 石沢 武彰. 【消化器外科における各種デバイスの使い方とピットフォール】肝胆膵 肝実質離断におけるエネルギーデバイスの使い方とピットフォール. 外科 85(4) 363-371 2023年4月

木下 正彦, 新川 寛二, 大平 豪, 木村 健二郎, 田中 肖吾, 石沢 武彰. 【イラストで見る消化器癌手術アトラス】肝胆膵 ICG蛍光イメージングを用いた肝切除ナビゲーション. 手術 77(6) 871-880 2023年5月

木下 正彦, 田中 肖吾, 石沢 武彰. 【肝疾患診療:最新のトピックスを学ぶ】肝切除におけるICG蛍光イメージング技術の活用. 肝臓クリニカルアップデート 9(1) 35-40 2023年5月

岡田 拓真, 木下 正彦, 木村 健二郎, 石沢 武彰. 【肝胆膵外科手術における術中トラブルシューティング】その他 肝胆膵手術における自動縫合器ミスファイヤへの対処法. 外科 85(8) 950-955 2023年7月

石沢 武彰, 木下 正彦, 木村 健二郎. 【生体イメージングの最前線-絶え間ない技術革新と生命医科学の新展開】新規解析・診断技術の動向 "蛍光ガイド手術"はすでに実現している. 医学のあゆみ 286(5) 489-495 2023年7月

久保 正二, 田中 肖吾, 新川 寛二, 木下 正彦, 石沢 武彰, 佐藤 保則. 【胆道癌と膵癌のリスクファクター】塩素系有機溶剤が原因と推定される職業性胆管癌の発癌病態. 胆と膵 44(9) 839-845 2023年9月

江口 真平, 山本 匠, 宮下 正寛, 上西 崇弘, 石沢 武彰. 【ラパコレを再考する-腹腔鏡下胆嚢摘出術をマスターするために】腹腔鏡下胆嚢摘出術における術中イメージング. 手術 77(10) 1457-1462 2023年9月

石沢 武彰, 木下 正彦, 西尾 康平, 大平 豪, 新川 寛二, 木村 健二郎. 肝胆膵外科における「蛍光ガイド手術」の現状と展望. 大阪市医学会雑誌 72 7-13 2023年12月

(2022年)

田中肖吾, 久保正二. 高齢消化器患者のADLや栄養の評価を実施できる. (実践!高齢者に対する消化器外科のminimal requirements, メジカルビュー社)

木村健二郎,田内潤,石沢武彰. 腹腔鏡下膵体尾部切除術における手術器具の使い方. (新DS NOW 腹腔鏡手術で器具を効率よく安全に使うスキル, メジカルビュー社)

萩原淳司, 吉田香奈子, 小塚立蔵, 榎本大, 竹村茂一, 田中肖吾, 久保正二, 河田則文. 肝細胞癌に対するカボザンチニブの初期使用経験. (肝癌に対するカボザンチニブによる肝細胞癌治療, アークメディア)

久保正二. 肝門浸潤を伴う肝内胆管癌に対する治療戦略. (胆道癌の診断と治療の動向, 第57回日本胆道学会大会記念誌)

久保正二, 島田光生, 永野浩昭, 波多野悦朗, 海堀昌樹, 玄田拓哉, 田中肖吾, 居村暁, 松井康輔, 徳光幸生, 中村育夫, 新川寛二, 木下正彦, 長谷川潔. 肝癌診療ガイドライン-手術. (消化器・肝臓内科, 科学評論社)

久保正二, 竹村茂一, 田中肖吾, 天野良亮, 新川寛二, 木下正彦. 肝内胆管癌におけるborderline resectableとは. (臨床雑誌外科, 南江堂)

久保正二, 田中肖吾, 竹村茂一, 新川寛二, 木下正彦, 佐藤保則, 三牧幸代, 土原一哉, 池田公史. 職業性胆管癌の病態と治療の進歩. (日本職業・災害医学会会誌)

久保正二, 新川寛二. 肝内胆管癌診療ガイドライン作成委員会. 肝内胆管癌診療ガイドライン2021年版策定のポイント. (臨床雑誌外科, 南江堂)

久保正二, 竹村茂一, 田中肖吾, 天野良亮, 木村健二郎, 新川寛二, 大平豪, 西尾康平, 田内潤, 木下正彦. 肝内結石症の長期予後. (胆と膵, 医学図書出版)