業績 Publications
Publications
(2026)
Characterization of the progressive neuroaxonal dystrophy and subsequent gait abnormalities in the Hspa8 knock-in rats.
Vet Pathol (in press).https://doi.org/10.1177/03009858261428505
Contrasting effects of PHD finger protein 24 (PHF24) on brain morphology of the spontaneous generalized tonic-clonic seizure model; Noda epileptic rat (NER) and Phf24-null rat.
Exp Anim (in press). https://doi.org/10.1538/expanim.25-0125
Urasaki M, Nagasaka K, Kido M, Hayashi K, Watanabe A, Hattori K, Sekiguchi T, Kuwamura M, Tanaka M, Mashimo T, Kuramoto T
A nonsense mutation in the Mocos gene induces xanthinuria, obstructive nephropathy, and anemia in rats.
Exp Anim (in press). https://doi.org/10.1538/expanim.25-0127
Obara RD, Kato Y, Asaoka Y, Oka H, Murata Y, Izawa T, Kuwamura M
Pathological features of the recovery phase in drug-induced vacuolar lesions caused by steroidogenesis disruption in the canine adrenal cortex.
J Toxicol Sci 51(1):57–73, 2026.https://doi.org/10.2131/jts.51.57
Hamada N, Ito Y, Niimi H, Atarashi M, Kuwamura M, Taguchi K, Yamamoto M, Izawa T
Nrf2 contributes to the protective effect of iron overload on thioacetamide-induced chronic liver injury in rats.
Toxicol Sci 209(2):kfaf165, 2026. https://doi.org/10.1093/toxsci/kfaf165
Tanaka M
Rat polyomavirus 2 infection - secondary publication. injury models.
Exp Anim 75(1):1–9, 2026. https://doi.org/10.1538/expanim.25-0072
Tanaka M, Morita C, Izawa T, Yamate J, Franklin RJM, Kuramoto T, Serikawa T, Kuwamura M
Impaired maturation and differentiation of oligodendrocytes in the vacuole formation myelin mutant rat
Vet Pathol 63(2):315-324, 2026. https://journals.sagepub.com/doi/10.1177/03009858251379486
Tokuno H, Fujimoto M, Tsuji M, Tanaka M, Izawa T, Kuwamura M
A canine insulinoma with amphicrine differentiation: the morphological and immunohistochemical characterizations.
J Toxicol Pathol 39(1):39–44, 2026. https://doi.org/10.1293/tox.2025-0062
Shimotsuma Y, Izawa T, Kuwamura M
Expression and distribution of Tribbles pseudokinase 3 (Trib3) in oxidative stress-mediated acute liver and kidney injury models.
J Toxicol Pathol 39(1):25–30, 2026. https://doi.org/10.1293/tox.2025-0040
Fujiwara S, Izawa T, Mori M, Kuwamura M
Influence of rapamycin and chloroquine on chemically-induced liver injury in rats.
J Toxicol Pathol 39(1):3–14, 2026. https://doi.org/10.1293/tox.2024-0104
(2025)
Horiuchi T, Izawa T, Kuwamura M
Inactivation of major hepcidin pathways leads to systemic and hepatic iron overload during development of chemically-induced liver cirrhosis in rats.
J Toxicol Pathol 38(4):247–256, 2025. https://doi.org/10.1293/tox.2025-0069
Takami Y, Nakamura J, Katahira J, Maeda Y, Tanaka M, Kuwamura M, Okada T, Izawa T
Systemic aldehyde storm induced by allyl alcohol exposure results in extensive hepatic ferroptosis in Aldh2∗2 knock-in mice.
Free Radic Biol Med 239: 177–188, 2025. https://doi.org/10.1016/j.freeradbiomed.2025.07.045
Jannat N, Tanaka M, Izawa T, Kobayashi Y, KuwamuraM
Expression of α-smooth muscle actin in the lateral ventricle wall of spontaneous hydrocephalus animals.
J Vet Med Sci 87(8):934–939, 2025. https://doi.org/10.1292/jvms.25-0153
Chambers JK, Watanabe K, Michishita M, Hatai H, Tanaka Y, Doge S, Ochiai K, Kato S, Goto-Koshino Y, Tanaka M, Izawa T; Japanese College of Veterinary Pathologists Standardization of Animal Tissue Processing Committee
Standardization of tissue handling in veterinary pathology: how fixation affects morphological and molecular examination results.
Vet Pathol 62(6):949–962, 2025. https://doi.org/10.1177/03009858251349126
Momota K, Kiyatake I,Izawa T, Aihara H, Kuraku S, Nishida K
First case of parthenogenesis in an intersexual zebra shark (Stegostoma tigrinum) having incomplete claspers.
J Fish Biol 107:1248–1255, 2025. https://doi.org/10.1111/jfb.70122
Rahman N, Izawa T, Kuwamura M, Yamate J
Participation of autophagy in D-galactosamine-induced acute rat liver injury.
J Vet Med Sci 87(8):881–886, 2025. https://doi.org/10.1292/jvms.25-0131
Nishida H, Matsuura H, Yoshizaki K, Sakaguchi Y, Izawa T, Sonoda H, Edamura K, Tabata Y
Sustained release of canine mesenchymal stem/stromal cell-derived extracellular vesicles rescues motor function in rodent spinal cord injury models.
Regen Ther 30:164-172, 2025. https://doi.org/10.1016/j.reth.2025.05.014
Yamada Y, Urakawa N, Tamiya H, Sakamoto S, Takahashi H, Harada N, Kitakaze T, Izawa T, Matsumua S, Yoshihara E, Inui H, Mashimo T, Yamaji R
Nrf2- and p53-inducible REDD2/DDiT4L/Rtp801L confers pancreatic β-cell dysfunction, leading to glucose intolerance in high-fat diet-fed mice.
J Biol Chem 301(6):110271, 2025. https://doi.org/10.1016/j.jbc.2025.110271
Nure J, Hasan MM, Tokuno H, Tanaka M, Izawa T, Yamate J, Kuwamura M
Aberrant alpha-smooth muscle actin expression in the lateral ventricle of Ccdc85C knockout rats.
Vet Pathol 62(3):364-370, 2025. https://doi.org/10.1177/03009858241312611
Sultana N, Izawa T, Kamei T, Fujiwara S, Ito Y, Takami Y, Kuwamura M
Application of humanized mice to toxicology studies: Properties of chimeric mice with humanized liver (PXB-mice) for hepatotoxicity.
J Toxicol Pathol 38(2):183-189, 2025. https://doi.org/10.1293/tox.2024-0092
Umeda Y, Izawa T(co-first author), Kazama K, Arai S, Kamiie J, Nakamura S, Hano K, Takasu M, Hirata A, Rittinghausen S, Yamano S
Comparative anatomy of respiratory bronchioles and lobular structures in mammals.
J Toxicol Pathol 38(2):113-129, 2025. https://doi.org/10.1293/tox.2024-0071
Habermaass V, Takami Y, Izawa T, Abramo F, Biolatti C, Marchetti V
Lipid dysmetabolism in canine chronic liver disease: relationship between clinical, histological and immunohistochemical features.
Vet Sci 12(3):220, 2025. https://doi.org/10.3390/vetsci12030220
Tokuno H, Tanaka M, Izawa T, Sasai H, Kuwamura M
A case of anaplastic oligodendroglioma in a rabbit (Oryctolagus cuniculus).
J Vet Med Sci 87(1):86-89, 2025. https://doi.org/10.1292/jvms.24-0438
Establishment of feline embryonic stem cells from the inner cell mass of blastocysts produced in vitro.
Regen Ther 28:63-722025. https://doi.org/10.1016/j.reth.2024.11.010
Kuramochi M, Karim MR, Izawa T, Kuwamura M, Yamate J
Myelin lesion in the aspartoacylase (Aspa) knockout rat, an animal model for Canavan disease.
Exp Anim 73(3):347-356, 2024. https://doi.org/10.1538/expanim.23-0089
Nishiyama K, Horikoshi J, Maehara T, Tanaka M, Tanida T, Kawada K, Takeshita S, Ono N, Izawa T, Kuwamura M, Azuma Y-T
Deficiency of interleukin-19 exacerbates acute lung injury induced by intratracheal treatment of hydrochloric acid.
J Pharmacol Sci 155(3):94-100, 2024. https://doi.org/10.1016/j.jphs.2024.04.003
Sakai H, Kamuro H, Tokunoh N, Izawa T, Tamiya S, Yamamoto A, Tanaka S, Okuzaki D, Ono C, Matsuura Y, Okada Y, Yoshioka Y, Fujio Y, Obana M
JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice.
Am J Physiol Renal Physiol 326(6):F931-F941, 2024. https://doi.org/10.1152/ajprenal.00011.2024
Inai Y, Izawa T, Kamei T, Fujiwara S, Tanaka M, Yamate J, Kuwamura M
Difference in the mechanism of iron overload-enhanced acute hepatotoxicity induced by thioacetamide and carbon tetrachloride in rats.
Toxicol Pathol 52(1):55-66, 2024. https://doi.org/10.1177/01926233241235623
Tanaka M, Fujikawa R, Sekiguchi T, Hernandez J, Johnson OT, Tanaka D, Kumafuji K, Serikawa T, Hoang Trung H, Hattori K, Mashimo T, Kuwamura M, Gestwicki JE and Kuramoto T
A missense mutation in the Hspa8 gene encoding heat shock cognate protein 70 causes neuroaxonal dystrophy in rats.
Front Neurosci 18:1263724, 2024. https://www.frontiersin.org/articles/10.3389/fnins.2024.1263724/abstract
Ono N, Horikoshi J, Izawa T, Nishiyama K, Tanaka M, Fujita T, Kuwamura M, Azuma YT
Functional role of IL-19 in a mouse model of L-arginine-induced pancreatitis and related lung injury.
Exp Anim 73(2):175-185, 2024. https://doi.org/10.1538/expanim.23-0094
Murakami T, Kobayashi N, Iwaide S, Itoh Y, Hisada M, Izawa T, Kuwamura M
Identification of calcitonin receptor-stimulating peptide 1-derived amyloid in a feline C-cell carcinoma.
Amyloid 31(2):142-144, 2024. https://doi.org/10.1080/13506129.2023.2282361
Tsukamoto M , Kimura K , Yoshida T , Tanaka M , Kuwamura M , AyabeT , Ishihara G , Watanabe K , Okada M , IijimaM , Nakanishi M , Akutsu H , Sugiura K , Hatoya S
Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors.
Stem Cell Reports 19(1):141-157, 2024. https://doi.org/10.1016/j.stemcr.2023.11.010
(2023)
Noguchi S, Toyota K, Ozaki M, Wada Y, Takami Y, Tanaka M, Kuwamura M, Shimada T
Successful management of nasopharyngitis caused by Schizophyllum commune in a captive cheetah (Acinonyx jubatus).
J Vet Med Sci 85(10):1074-1076, 2023. https://doi.org/10.1292/jvms.23-0273
Takami Y, Tanaka M*, Morita M, Maruno T, Anai N, Sudo T, Kezuka C, Izawa T, Yamate J, Kuwamura M
Watanabe S, Takagi A, Yuba E, Kojima C, Dei N, Matsumoto A, Tanikawa J, Kawamura T, De Silva NH, Izawa T, Akazawa T, Kanegi R, Hatoya S, Inaba T, Sugiura K
In vivo transfection of cytokine genes into tumor cells using a synthetic vehicle promotes antitumor immune responses in a visceral tumor model.
FASEB J 37(11):e23228, 2023. https://doi.org/10.1096/fj.202202036R
Pervin M, Ferdausi T, Miyuu T, Izawa T, Kuwamura M, Parvin R
Fatal avian pox in a backyard flock of domestic ducks in Bangladesh.
Vet Rec Case Rep e718, 2023. https://doi.org/10.1002/vrc2.718
Ono N, Fujita T, Miki M, Nishiyama K, Izawa T, Aoyama T, Kuwamura M, Fujii H, Azuma YT
Interleukin-19 gene-deficient mice promote liver fibrosis via enhanced TGF-β signaling, and the interleukin-19-CCL2 axis is important in the direction of liver fibrosis.
Biomedicines 11(7):2064, 2023. https://doi.org/10.3390/biomedicines11072064
Izawa T, Travlos GS, Cortes RA, Clayton NP, Sills RC, Pandiri AR
Absence of increased susceptibility to acetaminophen-induced liver injury in a diet induced NAFLD mouse model.
Toxicol Pathol 51(3):112-125, 2023. https://doi.org/10.1177/01926233231171101
Ando T, Izawa T, Nishida H, Akiyoshi H
Clinical findings using echocardiography and plasma cardiac troponin I and pathological findings in dogs with hypertrophic cardiomyopathy: A retrospective study.
Open Vet J 13(6):742-752, 2023. http://dx.doi.org/10.5455/OVJ.2023.v13.i6.9
Hasan MM, Konishi S, Tanaka M, Izawa T, Yamate J, Kuwamura M
Disrupted neurogenesis, gliogenesis, and ependymogenesis in the Ccdc85c knockout rat for hydrocephalus model.
Cells Dev 175:203858, 2023. https://doi.org/10.1016/j.cdev.2023.203858
Takami Y, Tanaka M, Izawa T, Kuwamura M, Yamate J
The effect of lipopolysaccharide on liver homeostasis and diseases based on the mutual interaction of macrophages, autophagy, and damage-associated molecular patterns in male F344/DuCrlCrlj rats.
Vet Pathol 60(4): 461-472, 2023. https://doi.org/10.1177/03009858231173364
Ono N, Horikoshi J, Izawa T, Nishiyama K, Tanaka M, Kuwamura M, Azuma Y-T
L-arginine-induced pancreatitis aggravated by inhibiting Na+/Ca2+ exchanger 1.
J Vet Med Sci 85(6):657-666, 2023. https://doi.org/10.1292/jvms.22-0569
Nakagawa M, Izawa T, Kuwamura M, Yamate J
Analyses of damage-associated molecular patterns, particularly biglycan, in cisplatin-induced rat progressive renal fibrosis.
J Toxicol Pathol 36(3):181-185, 2023. https://doi.org/10.1293/tox.2022-0148
Yamate J, Izawa T, Kuwamura M
Macrophage pathology in hepatotoxicity.
J Toxicol Pathol 36(2):51–68, 2023. https://doi.org/10.1293/tox.2022-0112
Ito T, Tanaka T, Kiyatake I, Izawa T, Furuya M, Sasai K
Contrast-enhanced computed tomography and cross-sectional anatomy of the trunk in the brownbanded bamboo shark (Chiloscyllium punctatum).
Anat Histol Embryol 52(3):437-447, 2023. https://doi.org/10.1111/ahe.12903
安積一平, 西田英高, 田中美有, 桑村充, 嶋崎等, 田中利幸, 山本卓矢, 秋吉秀保
肩甲骨及び硬膜外脂肪に認められた特発性無菌性化膿性肉芽腫のトイプードルの1例．
日本獣医学雑誌 76(5):75-80, 2023. https://doi.org/10.12935/jvma.76.e75
Hieu HT, Tanaka M, Kuwamura M, Mashimo T, Serikawa T, Kuramoto T
The rat Downunder (Du) coat color mutation is associated with eye anomaly and embryonic lethality and maps to the 3.9-Mb region on chromosome 3.
Exp Anim 72(1):88-94, 2023. https://doi.org/10.1538/expanim.22-0086
Hatoya S, Kanegi R, Nabetani T, Oji S, Izawa T, Hirai S, Sugiura K
Atypical hypoadrenocorticism with intact zona glomerulosa of the adrenal cortex after long-term observation: A case report of a dog.
J Vet Med Sci 85(1):9-13, 2023. https://doi.org/10.1292/jvms.22-0322
(2022)
Fujiwara S, Izawa T, Mori M, Atarashi M, Yamate J, Kuwamura M
Dietary iron overload enhances Western diet induced hepatic inflammation and alters lipid metabolism in rats sharing similarity with human DIOS.
Sci Rep 12:21414, 2022. https://doi.org/10.1038/s41598-022-25838-3
Sakamoto K, Lin B, Nunomura K, Izawa T, Nakagawa S
The K-Ras(G12D)-inhibitory peptide KS-58 suppresses growth of murine CT26 colorectal cancer cell-derived tumors.
Sci Rep 12(1):8121, 2022. https://doi.org/10.1038/s41598-022-12401-3
Pervin M, Karim MR, Kuramochi M, Izawa T, Kuwamura M, Yamate J
Possible cytoprotection of low dose lipopolysaccharide in rat thioacetamide-induced liver lesions, focusing on the analyses of hepatic macrophages and autophagy.
Toxicol Pathol 50(3):353-365, 2022. https://doi.org/10.1177/01926233221076758
Hasan MM, Konishi S, Tanaka M, Izawa T, Yamate J, Kuwamura M
Expression of CCDC85C, a causative protein for hydrocephalus, and intermediate filament proteins during lateral ventricle development in rats.
Exp Anim 71(1):100-108, 2022. https://doi.org/10.1538/expanim.21-0132