弓場英司

YUBA2

氏名　　：　　弓場　英司（ゆば　えいじ）
部屋　　：　　B5棟 6階 6B -38
TEL ：　 072-247-6016
Email ： yuba [at] omu.ac.jp

学歴

大阪府立大学工学部機能物質科学科卒業(2006)
大阪府立大学大学院工学研究科博士前期課程修了(2008)
大阪府立大学大学院工学研究科博士後期課程修了(2010)

職歴

日本学術振興会特別研究員（DC2）(2009)
大阪府立大学大学院工学研究科応用化学分野助教(2010)
大阪府立大学大学院工学研究科応用化学分野准教授(2017)
シカゴ大学(Prof. Jeffrey Hubbell)客員研究員(2019)
内閣府　政策統括官（科学技術・イノベーション担当）付　科学技術政策フェロー(2020)
内閣府　科学技術・イノベーション事務局　科学技術政策フェロー(2021)
大阪公立大学大学院工学研究科応用化学分野准教授(2022)
大阪公立大学　学長特別補佐(2022)

学位

博士（工学）（大阪府立大学、2010年）
学位論文："Design of Biofunctional Liposomes for Delivery of Bioactive Molecules"

所属学会

高分子学会，日本バイオマテリアル学会，日本ＤＤＳ学会，遺伝子・デリバリー研究会
日本薬学会，日本免疫学会，日本組織適合性学会
American Chemical Society

原著論文・総説

2022

109) B. Gupta, D. Sadaria, V. U. Warrier, A. Kirtonia, R. Kant, A. Awasthi, P. Baligar, J. K. Pal, E. Yuba, G. Sethi, M. Garg, R. K. Gupta, “Plant lectins and their usage in preparing targeted nanovaccines for cancer immunotherapy”, Semin. Cancer Biol., 80, 87-106 (2022). (Review) DOI:10.1016/j.semcancer.2020.02.005
108) S. Watanabe, E. Yuba, T. Akazawa, V. Wijewardana, Y. Kakihara, A. Azuma, K. Hagimori, R. Kanegi, S. Hatoya, N. Inoue, T. Inaba, K. Sugiura, "Potent adjuvant effect elicited for tumor immunotherapy by a liposome conjugated pH-sensitive polymer and dendritic cell-targeting Toll-like-receptor ligand", Vaccine, 40, 1448-1457 (2022). DOI: 10.1016/j.vaccine.2022.01.048
107) M.J.V. White, M.M. Raczy, E. Budina, E. Yuba, A. Solanki, H.N. Shim, Z.J. Zhang, L.T. Gray, S. Cao, A.T. Alpar, J.A. Hubbell, "Engineered collagen-targeting therapeutics reverse lung and kidney fibrosis in mice", bioRxiv, DOI: 10.1101/2022.01.04.474747

2021

106) S. Yanagihara, N. Kasho, K. Sasaki, N. Shironaka, Y. Kitayama, E. Yuba, A. Harada, "pH-Sensitive branched β-glucan-modified liposomes for activation of antigen presenting cells and induction of antitumor immunity", J. Mater. Chem. B, 9, 7713-7724 (2021). DOI: 10.1039/d1tb00786f
105) K. Noguchi, M. Obuki, H. Sumi, M. Kluβman, K. Morimoto, S. Nakai, T. Hashimoto, D. Fujiwara, I. Fujii, E. Yuba, T. Takatani-Nakase, I. Neundorf, I. Nakase, "Macropinocytosis-inducible extracellular vesicles modified with antimicrobial protein CAP18-derived cell-penetrating peptides for efficient intracellular delivery", Mol. Pharm., 18, 3290-33301 (2021). DOI: 10.1021/acs.molpharmaceut.1c00244
104) E. Yuba, M. Takashima, T. Hayashi, D. Kokuryo, I. Aoki, A. Harada, S. Aoshima, U. M. Krishnan, K. Kono, "Multifunctional traceable liposomes with temperature-triggered drug release and neovasculature-targeting properties for improved cancer chemotherapy", Mol. Pharm., 18, 3342-3351 (2021). DOI: 10.1021/acs.molpharmaceut.1c00263
103) E. Yuba, T. Korenaga, A. Harada, “Hydrophilic hyperbranched polymer-coated siRNA/polyamidoamine dendron-bearing lipid complexes preparation for high colloidal stability and efficient RNAi”, Bioconjugate Chemistry, 32, 53-571 (2021). DOI:10.1021/acs.bioconjchem.1c00035
102) E. Yuba, Y. Sugahara, Y. Yoshizaki, T. Shimizu, M. Kasai, K. Udaka, K. Kono, “Carboxylated polyamidoamine dendron-bearing lipid-based assemblies for precise control of intracellular fate of cargo and induction of antigen-specific immune responses”, Biomaterials Science, 9, 3076-3089 (2021). DOI:10.1039/D0BM01813A
101) I. Nakase, N. Ueno, M. Matsuzawa, K. Noguchi, M. Hirano, M. Omura, T. Takenaka, A. Sugiyama, N. B. Kobayashi, T. Hashimoto, T. Takatani‐Nakase, E. Yuba, I. Fujii, S. Futaki, T. Yoshida, “Environmental pH stress influences cellular secretion and uptake of extracellular vesicles”, FEBS Openbio., 11, 753-767 (2021). DOI:10.1002/2211-5463.13107
100) H. Setiawan, E. Yuba, A. Harada, I. Aoki, K. Kono, “Fabrication of gold nanohybrids modified with antibody and functional dendrimers for targeted photothermal theranostics”, Nano Select, 2, 7-790 (2021). DOI:10.1002/nano.202000218
99) E. Yuba, E. Budina, K. Katsumata, A. Ishihara, A. Mansurov, A. T. Alpar, E. A. Watkins, P. Hosseinchi, J. W. Reda, A. L. Lauterbach, M. Nguyen, A. Solanki, T. Kageyama, M. A. Swartz, J. Ishihara, J. A. Hubbell, “Suppression of rheumatoid arthritis by enhanced lymph node trafficking of engineered interleukin-10 in murine models”, Arthritis Rheumatol., 73, 769-778 (2021). DOI:10.1002/art.41585
98) A. Ishihara, J. Ishihara, E. A. Watkins, A. C. Tremain, M. Nguyen, A. Solanki, K. Katsumata, A. Mansurov, E. Budina, A. T. Alpar, P. Hosseinchi, L. Maillat, J. W. Reda, T. Kageyama, M. A. Swartz, E. Yuba, J. A. Hubbell, “Prolonged residence of an albumin–IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis”, Nat. Biomed. Eng., 5, 387-398 (2021). DOI:10.1038/s41551-020-00627-3

2020

97) 弓場英司, "pH応答性高分子とリポソームを基盤とした免疫誘導システムの開発", Drug Delivery System, 35, 426-433 (2020).
96) E. Yuba, Y. Fukaya, S. Yanagihara, N. Kasho, A. Harada, “Development of mannose-modified carboxylated curdlan-coated liposomes for antigen presenting cell targeted antigen delivery”, Pharmaceutics, 12, 754 (2020). DOI:10.3390/pharmaceutics12080754
95)弓場英司, "或る若手研究者の所感", バイオマテリアル-生体材料-, 38, 90 (2020).
94) T. Hashimoto, Y. Hirai, E. Yuba, A. Harada, K. Kono, “Temperature-responsive molecular assemblies using oligo(ethylene glycol)-attached polyamidoamine dendron lipids and their functions as drug carriers”, J. Funct. Biomater., 11, 16 (2020). DOI:10.3390/jfb11010016
93) T. Hashimoto, T. Hirata, E. Yuba, A. Harada, K. Kono, “Light-activatable transfection system using hybrid vectors composed of thermosensitive dendron lipids and gold nanorods”, Pharmaceutics, 12, 239 (2020). DOI:10.3390/pharmaceutics12030239
92) T. Hashimoto, E. Yuba, A. Harada, K. Kono, “Preparation of photothermal-chemotherapy nanohybrids by complexation of gold nanorods with polyamidoamine dendrimers having poly(ethylene glycol) and hydrophobic chains”, J. Mater. Chem. B, 8, 2826-2833 (2020). DOI:10.1039/C9TB02163A
91) E. Yuba, “Development of functional liposomes by modification of stimuli-responsive materials and their biomedical applications”, J. Mater. Chem. B, 8, 1093-1107 (2020). (Review) DOI:10.1039/C9TB02470K

2019

90) K. Katsumata, J. Ishihara, K. Fukunaga, A. Ishihara, E. Yuba, E. Budina, J. A. Hubbell, "Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-α antibody in a murine model of rheumatoid arthritis", Arthritis Res. Ther., 21, 298 (2019). DOI: 10.1186/s13075-019-2075-8.
89) D. P. H. Wijesekera, E. Yuba, N. H. De Silva, S. Watanabe, M. Tsukamoto, C. Ichida, T. Izawa, K. Itoh, R. Kanegi, S. Hatoya, J. Yamate, T. Inaba, K. Sugiura, "Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy", FASEB BioAdvances, 2, 5-17 (2020). DOI: 10.1096/fba.2019-00052.
88) K. Noguchi, M. Hirano, T. Hashimoto, E. Yuba, T. Takatani-Nakase, I. Nakase, "Effects of lyophilization of arginine-rich cell-penetrating peptide-modified extracellular vesicles on intracellular delivery", Anticancer Research, 39, 6701-6709 (2019). DOI:10.21873/anticanres.13885.
87) M. Miyazaki, E. Yuba, H. Hayashi, A. Harada, K. Kono, "Development of pH-responsive hyaluronic acid-based antigen carriers for induction of antigen-specific cellular immune responses", ACS Biomaterials Science & Engineering, 5, 5790-5797 (2019). DOI: 10.1021/acsbiomaterials.9b01278.
86) K. Katsumata, J. Ishihara, A. Mansurov, A. Ishihara, M. M. Raczy, E. Yuba, J. A. Hubbell, "Targeting inflammatory sites through collagen affinity enhances the therapeutic efficacy of anti-inflammatory antibodies", Science Advances, 5, eaay1971 (2019). DOI: 10.1126/sciadv.aay1971.
85) V. U. Warrier, A. I. Makandar, M. Garg, G. Sethi, R. Kant, J. K. Pal, E. Yuba, R. K. Gupta, "Engineering anti-cancer nanovaccine based on antigen cross-presentation", Biosc. Rep., 39, BSR20193220 (2019). DOI: 10.1042/BSR20193220.
84) 弓場英司, "pH応答性高分子を基盤とした免疫誘導システムの設計", Drug Delivery System, 34, 163-172 (2019).
83) M. Okubo, M. Miyazaki, E. Yuba, A. Harada, "Chondroitin sulfate-based pH-sensitive polymer-modified liposomes for intracellular antigen delivery and induction of cancer immunity", Bioconjugate Chemistry, 30, 1518-1529 (2019). DOI: 10.1021/acs.bioconjchem.9b00221.
82) A. Harada, K. Nomura, E. Yuba, K. Kono, "Gene expression of aspect ratio-controlled polyplexes based on the effect of multi-arm poly(ethylene glycol)", ACS Biomaterials Science & Engineering, 5, 5681-5687 (2019). DOI: 10.1021/acsbiomaterials.8b01498.
81) S. Kaviarasi, E. Yuba, A. Harada, U. M. Krishnan, "Emerging paradigms in nanotechnology for imaging and treatment of cerebral ischemia", J. Control. Release, 300, 22-45 (2019). DOI: 10.1016/j.jconrel.2019.02.031.
80) S. Kaviarasi, K. S. S. Devi, P. Vinoth, V. Sridharan, E. Yuba, A. Harada, U. M. Krishnan, “Synthesis, characterization, and biomedical applications of an alkylated quercetin–gadolinium complex”, ACS Biomaterials Science & Engineering, 5, 1215-1227 (2019). DOI: 10.1021/acsbiomaterials.8b01254.
79) R. Teranishi, T. Matsuda, E. Yuba, K. Kono, A. Harada, "Sonodynamic therapeutic effects of sonosensitizers with different intracellular distribution delivered by hollow nanocapsules exhibiting cytosol specific release", Macromolecular Bioscience, 19, e1800365 (2019). DOI: 10.1002/mabi.201800365.
78) 弓場英司, "免疫づくり", 高分子, 68, 75 (2019).

2018

77) 弓場英司，「機能性分子の表面修飾による刺激応答性リポソームの創製とそのバイオ応用」,粉体の表面処理・複合化技術集大成-基礎から応用まで-，423-431 (2018) テクノシステム．
76) 弓場英司, 「pH応答性多糖とリポソームを基盤とした免疫誘導システムの開発」, 高分子論文集, 75, 433-443 (2018). DOI: 10.1295/koron.2018-0013.
75) 弓場英司，「機能性高分子の表面修飾による細胞特異的リポソームDDSの設計」, J. Soc. Powder Technol., Japan, 55, 389-396 (2018). DOI: 10.4164/sptj.55.389.
74) E. Yuba, “Liposome-based immunity-inducing systems for cancer immunotherapy”, Molecular Immunology, 98, 8-12 (2018). (Review) DOI: 10.1016/j.molimm.2017.11.001.
73) 藤原大佑，弓場英司，白石一乗，中瀬生彦，藤井郁雄，「ポスト抗体医薬品：立体構造規制ペプチド「マイクロ抗体」を土台とした中分子創薬」, MEDCHEM NEWS, 28, 83-87 (2018).
72) 山本聡, 古川和樹, 小野雅文, 弓場英司, 原田敦史, 河野健司，「TiO₂ナノ粒子内包ポリイオンコンプレックスミセルによる疎水性プロドラッグの可溶化と超音波照射効果」, 高分子論文集, 75, 42-47 (2018). DOI: 10.1295/koron.2017-0063.
71) M. Miyazaki, E. Yuba, H. Hayashi, A. Harada, K. Kono, “Hyaluronic acid-based pH-sensitive polymer-modified liposomes for cell-specific intracellular drug delivery systems”, Bioconjugate Chem., 29, 44-55 (2018). DOI: 10.1021/acs.bioconjchem.7b00551.
70) E. Yuba, T. Osaki, M. Ono, S. Park, A. Harada, M. Yamashita, K. Azuma, T. Tsuka, N. Ito, T. Imagawa, Y. Okamoto, “Bleomycin-loaded pH-sensitive polymer-lipid-incorporated liposomes for cancer chemotherapy”, Polymers, 10, 74 (2018). DOI: 10.3390/polym10010074. [Open Access]
69) M. Tsuruta, S. Ueda, P.Y. Yew, I. Fukuda, S. Yoshimura, H. Kishi, H. Hamana, M. Hirayama, J. Yatsuda, A. Irie, S. Senju, E. Yuba, T. Kamba, M. Eto, H. Nakayama, Y. Nishimura, “Bladder cancer-associated cancer-testis antigen-derived long peptides encompassing both CTL and promiscuous HLA class II-restricted Th cell epitopes induced CD4+ T cells expressing converged T-cell receptor genes in vitro”, OncoImmunology, 7, e1415687 (2018). DOI: 10.1080/2162402X.2017.1415687.
68) 弓場英司，原田敦史，「DDS応用を指向した刺激応答性リポソームの設計」, ファルマシア, 54, 11-15 (2018). DOI: 10.14894/faruawpsj.54.1_11.
67) S. Okazaki, T. Iwasaki, E. Yuba, S. Watarai, “Evaluation of pH-sensitive fusogenic polymer-modified liposomes co-loaded with antigen and α-galactosylceramide as an anti-tumor vaccine”, J. Vet. Med. Sci., 80, 197-204 (2018). DOI: 10.1292/jvms.17-0491. [Free Access]
66) S. Uchida, N. Yoshinaga, K. Yanagihara, E. Yuba, K. Kataoka, K. Itaka, “Designing immunostimulatory double stranded messenger RNA with maintained translational activity through hybridization with poly A sequences for effective vaccination”, Biomaterials, 150, 162-170 (2018). DOI: 10.1016/j.biomaterials.2017.09.033.
65) N. Yamazaki, S. Yamakawa, T. Sugimoto, Y. Yoshizaki, R. Teranishi, T. Hayashi, A. Kotaka, C. Shinde, T. Kumei, Y. Sumida, T. Shimizu, Y. Ohashi, E. Yuba, A. Harada, K. Kono, “Carboxylated phytosterol derivative-introduced liposomes for skin environment-responsive transdermal drug delivery system”, J. Liposome Res., 28, 275-284 (2018). DOI: 10.1080/08982104.2017.1369995.

2017

64) E. Yuba, N. Sakaguchi, Y. Kanda, M. Miyazaki, K. Koiwai, “pH-responsive micelle-based cytoplasmic delivery system for induction of cellular immunity”, Vaccines, 5, 41 (2017). DOI: 10.3390/vaccines5040041. [Open Access]
63) S. Yamamoto, M. Ono, E. Yuba, A. Harada, “In vitro sonodynamic therapeutic effect of polyion complex micelles incorporating titanium dioxide nanoparticles”, Nanomaterials, 7, 268 (2017). DOI: 10.3390/nano7090268. [Open Access]
62) E. Yuba, S. Uesugi, M. Miyazaki, Y. Kado, A. Harada, K. Kono, “Development of pH-sensitive dextran derivatives with strong adjuvant function and their application to antigen delivery”, Membranes, 7, 41 (2017). DOI: 10.3390/membranes7030041. [Open Access]
61)　Y. Yoshizaki, E. Yuba, N. Sakaguchi, K. Koiwai, A. Harada, K. Kono, “pH-sensitive polymer-modified liposome-based immunity-inducing system: effects of inclusion of cationic lipid and CpG-DNA”, Biomaterials, 141, 272-283 (2017). DOI: 10.1016/j.biomaterials.2017.07.001.
60)　A. Harada, R. Teranishi, E. Yuba, K. Kono, “Effect of the side chain spacer structure on the pH-responsive properties of polycarboxylates”, Journal of Biomaterials Science: Polymer Edition, 28, 1025-1035 (2017). DOI: 10.1080/09205063.2017.1324551.
59) E. Yuba, S. Uesugi, Y. Yoshizaki, A. Harada, K. Kono, “Potentiation of cancer immunity-inducing effect by pH-sensitive polysaccharide-modified liposomes with combination of TGF-β type I receptor inhibitor-embedded liposomes”, Med. Res. Arch., 5, (2017). DOI: 10.18103/mra.v5i5.1243. [Open Access]
58) T．Sugimoto, N. Yamazaki, T. Hayashi, E. Yuba, A. Harada, A. Kotaka, C. Shinde, T. Kumei, Y. Sumida, M. Fukushima, Y. Munekata, K. Maruyama, K. Kono, “Preparation of dual-stimuli-responsive liposomes using methacrylate-based copolymers with pH and temperature sensitivities for precisely controlled release”, Colloids Surf. B: Biointerfaces, 155, 449-458 (2017). DOI: 10.1016/j.colsurfb.2017.04.043.
57) D. Kokuryo, I. Aoki, E. Yuba, K. Kono, S. Aoshima, J. Kershaw, T. Saga, “Evaluation of a combination tumor treatment using thermo-triggered liposomal drug delivery and carbon-ion irradiation”, Translational Research, 185, 24-33 (2017). DOI: 10.1016/j.trsl.2017.04.001. [Open Access]
56) N. Yamazaki, T. Sugimoto, M. Fukushima, R. Teranishi, A. Kotaka, C. Shinde, T. Kumei, Y. Sumida, Y. Munekata, K. Maruyama, E. Yuba, A. Harada, K. Kono, “Dual-stimuli responsive liposomes using pH- and temperature-sensitive polymers for controlled transdermal delivery”, Polymer Chemistry, 8, 1507-1518 (2017). DOI: 10.1039/c6py01754a.
55) R. Teranishi, R. Matsuki, E. Yuba, A. Harada, K. Kono, “Doxorubicin delivery using pH and redox dual-responsive hollow nanocapsules with a cationic electrostatic barrier”, Pharmaceutics, 9, 4 (2017). DOI: 10.3390/pharmaceutics9010004. [Open Access]
54) E. Yuba, A. Yamaguchi, Y. Yoshizaki, A. Harada, K. Kono, “Bioactive polysaccharide-based pH-sensitive polymers for cytoplasmic delivery of antigen and activation of antigen-specific immunity”, Biomaterials, 120, 32-45 (2017). DOI: 10.1016/j.biomaterials.2016.12.021.
53) Y. Shimizu, T. Iwasaki, T. Tajima, E. Yuba, K. Kono, S. Watarai, “Induction of antibody response in the oral cavity of dogs following intraocular (eye drop) immunization with Porphyromonas gingivalis cell lysate incorporated in pH-sensitive fusogenic polymer-modified liposomes”, J. Vet. Med. Sci., 79, 290-298 (2017). DOI: 10.1292/jvms.16-0338.

2016

52) Y. Yoshizaki, E. Yuba, T. Komatsu, K. Udaka, A. Harada, K. Kono, “Improvement of peptide-based tumor immunotherapy using pH-sensitive fusogenic polymer-modified liposomes”, Molecules, 21, 1284 (2016). DOI:10.3390/molecules21101284. [Open Access]
51) D. Fujiwara, H. Kitada, M. Oguri, T. Nishihara, M. Michigami, K. Shiraishi, E. Yuba, I. Nakase, H. Im, S. Cho, J. Y. Joung, S. Kodama, K. Kono, S. Ham, I. Fujii, “A cyclized helix-loop-helix peptide as a molecular scaffold for the design of inhibitors of intracellular protein-protein interactions by epitope and arginine grafting”, Angew. Chem. Int. Ed., 128, 10770-10773 (2016). DOI:10.1002/ange.201603230.
50) 弓場英司，原田敦史, 河野健司, 「免疫治療のためのDDS最前線」, 高分子, 65, 435-440 (2016).
49) S. A. Chechetka, E. Yuba, K. Kono, M. Yudasaka, A. Bianco, E. Miyako, “Magnetically- and near infrared light-powered supramolecular nanotransporters for the remote control of enzymatic reactions”, Angew. Chem. Int. Ed., 55, 6476-6481 (2016). DOI: 10.1002/anie.201602453 and 10.1002/ange.201602453.
48) E. Yuba, “Design of pH-sensitive polymer-modified liposomes for antigen delivery and their application in cancer immunotherapy”, Polymer Journal, 48, 761-771 (2016). DOI:10.1038/pj.2016.31.
47) M. Hirayama, Y. Tomita, A. Yuno, H. Tsukamoto, S. Senju, Y. Imamura, M. A. Sayem, A. Irie, Y. Yoshitake, D. Fukuma, M. Shinohara, A. Hamada, H. Jono, E. Yuba, K. Kono, K. Yoshida, T. Tsunoda, H. Nakayama, Y. Nishimura, “An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs”, OncoImmunology, 5, e1123368 (2016). DOI:10.1080/2162402X.2015.1123368. [Open Access]
46)　M. A. Sayem, Y. Tomita, A. Yuno, M. Hirayama, A. Irie, H. Tsukamoto, S. Senju, E. Yuba, T. Yoshikawa, K. Kono, T. Nakatsura, Y. Nishimura, “Identification of glypican-3-derived long peptides activating both CD8+ and CD4+ T-cells; prolonged overall survival in cancer patients with Th cell response”, OncoImmunology, 5, e1062209 (2016). DOI: 10.1080/2162402X.2015.1062209. [Open Access]

2015

45)　E. Miyako, S. A. Chechetka, M. Doi, E. Yuba, K. Kono, “In vivo remote control of reactions in Caenorhabditis elegans by using supramolecular nanohybrids of carbon nanotubes and liposomes", Angew. Chem. Int. Ed., 54, 9903-9906 (2015). DOI: 10.1002/anie.201504987.
44) K. Kono, M. Takashima, E. Yuba, A. Harada, Y. Hiramatsu, H. Kitagawa, T. Otani, K. Maruyama, S. Aoshima, “Multifunctional liposomes having target specificity, temperature-triggered release, and near-infrared fluorescence imaging for tumor-specific chemotherapy”, J. Control. Release, 216, 69-77 (2015). DOI: 10.1016/j.jconrel.2015.08.005.
43) S. Yamamoto, E. Yuba, A. Harada, K. Kono, "Effective condensation of multivalent anions into polyion complex micelles prepared from TiO₂ nanoparticles and polyallylamine bearing poly(ethylene glycol) grafts", Langmuir, 31, 8583-8588 (2015). DOI: 10.1021/acs.langmuir.5b01883.
42) E. Yuba, Y. Kanda, Y. Yoshizaki, R. Teranishi, A. Harada, K. Sugiura, T. Izawa, J. Yamate, N. Sakaguchi, K. Koiwai, K. Kono, “pH-Sensitive polymer-liposome-based antigen delivery systems potentiated with interferon-γ gene lipoplex for efficient cancer immunotherapy”, Biomaterials, 67, 214-224 (2015). DOI: 10.1016/j.biomaterials.2015.07.031.
41) T. Doura, M. Yamada, R. Teranishi, Y. Yamamoto, T. Sugimoto, E. Yuba, A. Harada, K. Kono, "PAMAM dendron lipid assemblies that undergo structural transition in response to weakly acidic pH and their cytoplasmic delivery capability", Langmuir, 31, 5105-5114 (2015). DOI: 10.1021/acs.langmuir.5b00183.
40) R. Aono, K. Nomura, E. Yuba, A. Harada, K. Kono , "Gene expression of ternary complexes through the compaction of nanofiber-polyplexes by mixing with Lipofectamine", Biomaterials Science, 3, 764-770 (2015). DOI: 10.1039/C5BM00081E.
39)　弓場英司, "pH応答性高分子を基盤としたがん免疫治療用抗原デリバリーシステムの設計", Drug Delivery System, 30, 160-161 (2015).
38)　X. Li, Y. Watanabe, E. Yuba, A. Harada, T. Haino, K. Kono, "Facile construction of well-defined fullerene-dendrimer supramolecular nanocomposites for bioapplications", Chem. Commun., 51, 2851-2854 (2015). DOI: 10.1039/C4CC09082A.
37)　D. Kokuryo, S. Nakashima, F. Ozaki, E. Yuba, K. H. Chuang, S. Aoshima, Y. Ishizaka, T. Saga, K. Kono, I. Aoki, "Evaluation of thermo-triggered drug release in intramuscular-transplanted tumors using thermosensitive polymer-modified liposomes and MRI", Nanomedicine-Nanotechnology, Biology and Medicine, 11, 229-238 (2015). DOI: 10.1016/j.nano.2014.09.001.

2014

36)　K. Kono, T. Kaiden, E. Yuba, Y. Sakanishi, A. Harada, "Synthesis of oligoethylene glycol-modified hyperbranched polyglycidols for dual sensitization of liposomes to pH and temperature", J. Taiwan Institute of Chemical Engineers, 45, 3054-3061 (2014). DOI：10.1016/j.jtice.2014.06.011.
35)　D. P. H. Wijesekera, K. Sugiura, E. Yuba, K. Ueda, V. Wijewardana, R. Kanegi, T. Nishimura, T. Ushigusa, S. Hatoya, K. Kono, T. Inaba, “Enhancement of anti-tumor immune responses by transfection of IFNγ gene into tumor using a novel type synthetic vector”, Veterinary Immunology and Immunopathology, 162, 59-64 (2014). DOI: 10.1016/j.vetimm.2014.08.016.
34)　Y. Yoshizaki, E. Yuba, N. Sakaguchi, K. Koiwai, A. Harada, K. Kono, “Potentiation of pH-sensitive polymer-modified liposomes with cationic lipid inclusion as antigen delivery carriers for cancer immunotherapy”, Biomaterials, 35, 8186-8196 (2014). DOI:10.1016/j.biomaterials.2014.05.077.
33)　K. Kono, K. Takeda, X. Li, E. Yuba, A. Harada, T. Ozaki, S. Mori, "Dually functionalized dendrimers by temperature-sensitive surface modification and gold nanoparticle loading for biomedical application", RSC Adv., 4, 27811-27819 (2014). DOI: 10.1039/c4ra03947e.
32)　X. Li, K. Takeda, E. Yuba, A. Harada, K. Kono, “Preparation of PEG-modified PAMAM dendrimers having gold nanorod core and their application to photothermal therapy”, J. Mater. Chem. B, 2, 4167-4176 (2014). DOI:10.1039/C4TB00132J.
31)　X. Li, M. Takashima, E. Yuba, A. Harada, K. Kono, “PEGylated PAMAM dendrimer-doxorubicin conjugate-hybridized gold nanorod for combined photothermal-chemotherapy”, Biomaterials, 35, 6576-6584 (2014). DOI:10.1016/j.biomaterials.2014.04.043.
30)　R. Aono, E. Yuba, A. Harada, K. Kono, "Nanofiber polyplex formation based on the morphology elongation by the intra-polyplex PEG crowding effect", ACS Macro Lett., 3, 333-336 (2014). DOI: 10.1021/mz500072k.
29)　E. Yuba, K. Kono, "Nasal delivery of biopharmaceuticals", In "Mucosal Delivery of Biopharmaceuticals", pp.197-220, Springer Science, New York (2014). DOI:10.1007/978-1-4614-9524-6_8.
28)　E. Yuba, N. Tajima, Y. Yoshizaki, A. Harada, H. Hayashi, K. Kono, "Dextran derivative-based pH-sensitive liposomes for cancer immunotherapy", Biomaterials, 35, 3091-3101 (2014). DOI:10.1016/j.biomaterials.2013.12.024.
27)　S. Watarai, T. Iwase, T. Tajima, E. Yuba, K. Kono, Y. Sekiya, "Application of pH-sensitive fusogenic polymer-modified liposomes for development of mucosal vaccines", Veterinary Immunology and Immunopathology, 158, 62-72 (2014). DOI:10.1016/j.vetimm.2013.05.005.
26)　弓場英司, 「がん免疫治療用抗原デリバリーシステムとしてのpH応答性ポリマー修飾リポソーム」, バイオマテリアル-生体材料-, 32(1), 42-44 (2014).

2013

25)　弓場英司, 「pH応答性ポリマー修飾リポソームを用いた抗原デリバリーとがん免疫治療への応用」, Major Histocompatibility Complex, 20, 181-189 (2013). DOI:10.12667/mhc.20.181. [Free Access]
24) A. Harada, R. Matsuki, S. Ichimura, E. Yuba, K. Kono, "Intracellular environment-responsive stabilization of polymer vesicles formed from head-tail type polycations composed of polyamidoamine dendron and poly (L-lysine)", Molecules, 18, 12168-12179 (2013). DOI:10.3390/molecules181012168. [Open Access]
23)　弓場英司, 河野健司, 「バイオ機能リポソームと免疫治療」, 化学, 68, 66-67 (2013).
22) E. Yuba, Y. Kono, A. Harada, S. Yokoyama, M. Arai, K. Kubo, K. Kono, "The application of pH-sensitive polymer-lipids to antigen delivery for cancer immunotherapy", Biomaterials, 34, 5711-5721 (2013). DOI:10.1016/j.biomaterials.2013.04.007.
21)　X. Li, Y. Haba, K. Ochi, E. Yuba, A. Harada, K. Kono, "PAMAM dendrimers with oxyethylene unit-enriched surface as biocompatible temperature-sensitive dendrimers", Bioconjugate Chem., 24, 282-290 (2013). DOI:10.1021/bc300190v.
20) S. Watarai, T. Iwase, T. Tajima, E. Yuba, K. Kono, "Efficiency of pH-sensitive fusogenic polymer-modified liposomes as a vaccine carrier", Scientific World J., 2013, 903234 (2013). DOI:10.1155/2013/903234. [Open Access]
19)　E. Yuba, A. Harada, Y. Sakanishi, S. Watarai, K. Kono, "A liposome-based antigen delivery system using pH-sensitive fusogenic polymers for cancer immunotherapy", Biomaterials, 34, 3042-3052 (2013). DOI:10.1016/j.biomaterials.2012.12.031.
18)　A. Harada, M. Ono, E. Yuba, K. Kono, "Titanium dioxide nanoparticles-entrapped polyion complex micelles generate singlet oxygen in the cells by ultrasound irradiation for sonodynamic therapy", Biomaterials Science, 1, 65-73 (2013). DOI: 10.1039/C2BM00066K.

2012

17)　S. Iwashita, Y. Hiramatsu, T. Otani, C. Amano, M. Hirai, K. Oie, E. Yuba, K. Kono, M. Miyamoto, K. Igarashi, "Polyamidoamine dendron-bearing lipid assemblies:Their morphologies and gene transfection ability", J. Biomaterials Applications, 27, 445-456 (2012). DOI:10.1177/0885328211411955.
16) E. Miyako, K. Kono, E. Yuba, C. Hosokawa, H. Nagai, Y. Hagihara, "Carbon nanotube-liposome supramolecular nanotrains for intelligent molecular-transport systems", Nature Commun., 3, 1226 (2012). DOI:10.1038/ncomms2233. [Open Access]
15)　T. Hebishima, E. Yuba, K. Kono, S. Takeshima, Y. Ito, Y. Aida, “The pH-sensitive fusogenic 3-methyl-glutarylated hyperbranched poly(glycidol) (MGlu-HPG)-conjugated liposome induces antigen-specific cellular and humoral immunity”, Clinical and Vaccine Immunology, 19, 1492-1498 (2012). DOI:10.1128/CVI.00273-12. [Free Access]
14)　E. Yuba, Y. Nakajima, K. Tsukamoto, S. Iwashita, C. Kojima, A. Harada, K. Kono, "Effect of unsaturated alkyl chains on transfection activity of poly(amidoamine) dendron-bearing lipids", J. Control. Release, 160, 552-560 (2012). DOI:10.1016/j.jconrel.2012.04.002.
13)　K. Kono, R. Ikeda, K. Tsukamoto, E. Yuba, C. Kojima, A. Harada, "Polyamidoamine dendron-bearing lipids as a non-viral vector: influence of dendron generation", Bioconjugate Chem., 23, 871-879 (2012). DOI:10.1021/bc200368b.

2011

12)　T. Kaiden, E. Yuba, A. Harada, Y. Sakanishi, K. Kono, "Dual signal-responsive liposomes for temperature-controlled cytoplasmic delivery", Bioconjugate Chem., 22(10), 1909-1915 (2011). DOI:10.1021/bc2000353.
11)　河野健司, 弓場英司, 「高分子の表面修飾による機能性リポソームの設計」, 膜, 36, 183-190 (2011).
10)　K. Kono, E. Murakami, Y. Hiranaka, E. Yuba, C. Kojima, A. Harada, K. Sakurai, "Thermosensitive molecular assemblies from PAMAM dendron-based lipids", Angew. Chem. Int. Ed., 50, 6332-6336 (2011). DOI:10.1002/anie.201101007.
9)　A. Harada, S. Ichimura, E. Yuba, K. Kono, "Hollow nanocapsules prepared through stabilization of polymer vesicles formed from head-tail type polycations by introducing cross-linkages", Soft Matter, 7(10), 4629-4635 (2011). DOI:10.1039/c1sm05075c.
8)　K. Kono, S. Nakashima, D. Kokuryo, I. Aoki, H. Shimomoto, S. Aoshima, K. Maruyama, E. Yuba, C. Kojima, A. Harada, Y. Ishizaka, "Multifunctional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy", Biomaterials, 32, 1387-1395 (2011). DOI:10.1016/j.biomaterials.2010.10.050.
7)　E. Yuba, A. Harada, Y. Sakanishi, K. Kono, "Carboxylated hyperbranched poly(glycidol)s for preparation of pH-sensitive liposomes", J. Control. Release, 149, 72-80 (2011). DOI:10.1016/j.jconrel.2010.03.001.

2010

6)　E. Yuba, C. Kojima, A. Harada, Tana, S. Watarai, K. Kono, pH-Sensitive fusogenic polymer-modified liposomes as a carrier of antigenic proteins for activation of cellular immunity, Biomaterials, 2010, 31 (5), 943-951.

2009

5)　L. T. Ng, E. Yuba, K. Kono, "Modification of liposome surface with ph-responsive polyampholytes for the controlled-release of drugs", Res. Chemical Intermediates, 35, 1015-1025 (2009).
4)　T. Takahashi, E. Yuba, C. Kojima, A. Harada, K. Kono, "Synthesis of a polyamidoamine dendron-bearing lipid having sugar moieties and its use for preparation of nonviral gene vectors", Res. Chemical Intermediates, 35, 1005-1014 (2009). DOI:10.1007/s11164_009_0083_z.
3) 河野健司，弓場英司，「細胞内で機能するリポソーム」，未来材料，9 (3), 12-19 (2009).

2008

2) C. Kojima, Y. Hirano, E. Yuba, A. Harada, K. Kono, "Preparation and characterization of complexes of liposomes with gold nanoparticles", Colloids Surf. B:Biointerfaces, 66, 246-252 (2008). DOI:10.1016/j.colsurfb.2008.06.022.
1) E. Yuba, C. Kojima, N. Sakaguchi, A. Harada, K. Koiwai, K. Kono, "Gene delivery to dendritic cells mediated by complexes of lipoplexes and pH-sensitive fusogenic polymer-modified liposomes", J. Control. Release, 130, 77-83 (2008). DOI:10.1016/j.jconrel.2008.05.007.

著書

11) T. S. Chaitanya, S. N. Patil, S. Ghosh, J. K. Pal, E. Yuba, R. K. Gupta, "Cross-presentation-based nanovaccine for cancer immunotherapy", In "Nanotherapeutics in Cancer Vaccination and Challenges", Academic Press, 349-396 (2022).
10) 弓場英司，「pH応答性リポソームの設計とDDS応用」,刺激応答性高分子ハンドブック, 497-506 (2018) エヌ・ティー・エス．
9) E. Yuba, “Stimuli-responsive polymer-modified liposomes and their application to DDS”, In "Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications”, Elsevier, Vol. 2, 305-319 (2018).
8) 弓場英司，「抗原-サイトカイン同時デリバリーシステムの構築とナノワクチンの創製」,ドラッグデリバリーシステム-バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発-，138-146 (2018) シーエムシー．
7)　弓場英司，「がん免疫療法用の抗原デリバリーシステム開発」,DDS先端技術の製剤への応用開発, 270-282 (2017) 技術情報協会.
6)　弓場英司，「高分子と脂質の構造をもつデンドロン脂質ベクターの開発と活性評価」, DDS先端技術の製剤への応用開発, 304-312 (2017) 技術情報協会.
5)　弓場英司, 河野健司, 「ポリマー修飾」, DDSキャリア作製プロトコル集, pp. 42-52 (2015) シーエムシー.
4)　弓場英司, 河野健司, 「デンドリマー」, DDSキャリア作製プロトコル集, pp. 89-98 (2015) シーエムシー.
3)　E. Yuba, K. Kono, "Nasal delivery of biopharmaceuticals", In "Mucosal Delivery of Biopharmaceuticals", pp.197-220, Springer Science, New York (2014). DOI:10.1007/978-1-4614-9524-6_8
2)　弓場英司, 河野健司, 「高感度pH応答性リポソームのワクチンへの応用」, ドラッグデリバリーシステムの新展開II－核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術－, pp. 189-197 (2012) シーエムシー.
1)　弓場英司，河野健司，「機能性リポソーム」，超分子サイエンス＆テクノロジー，pp. 1180-1185 (2009), エヌ・ティー・エス．

弓場 英司

学歴

職歴

学位