プロフィール：教授 池田 一雄
教授 池田 一雄
教授 池田 一雄
Prof: IKEDA, Kazuo
自己紹介
教室では、肝がんやNASHなど様々な肝病態下における肝星細胞の役割や臓器線維症に関する研究に取り組んでいます。大学を卒業後、6年間肝臓外科を専攻し、その後に金田研司教授の研究指導を受け、肝星細胞の研究を始め、ニューヨーク、マウントサイナイ医科大学（フリードマン教授に師事）に留学、名古屋市立大学医学部を経て、2011年より現職となっていますが、継続して肝星細胞の研究を行っています。大学院生、学部生にも形態学の重要性、研究の楽しさを体感してもらいたいと思っています。趣味はサッカー観戦。
略歴
| 1989年 6月 | 大阪市立大学医学部付属病院臨床研修医（第二外科） |
| 1995年 6月 | 大阪市立大学医学部助手（第二解剖学教室） |
| 1999年 4月 | 米国マウントサイナイ医科大学. Scott L.Friedman教授（肝臓病学）のもとへ博士研究員として留学 |
| 2002年 4月 | 大阪市立大学大学院医学研究科講師（器官構築形態学） |
| 2004年 1月 | 大阪市立大学大学院医学研究科助教授（器官構築形態学） |
| 2007年 4月 | 大阪市立大学大学院医学研究科准教授（器官構築形態学） |
| 2008年 9月 | 名古屋市立大学大学院医学研究科教授（機能解剖学分野） |
| 2011年 7月 | 大阪市立大学大学院医学研究科教授（機能細胞形態学） |
| 2020年 4月 | 大阪市立大学大学院医学研究科副研究科長 |
| 2022年 4月 | 大阪公立大学大学院医学研究科教授（機能細胞形態学） |
| 2022年 4月 | 大阪公立大学 副学長 現在に至る |
主な研究業績
1: Urushima H, Matsubara T, Miyakoshi M, Kimura S, Yuasa H, Yoshizato K, Ikeda K. Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway. Am J Physiol Gastrointest Liver Physiol. 2023 Jan 31. doi:10.1152/ajpgi.00138.2022. Epub ahead of print. PMID: 36719093.
2: Kawamura E, Matsubara T, Daikoku A, Deguchi S, Kinoshita M, Yuasa H, Urushima H, Odagiri N, Motoyama H, Kotani K, Kozuka R, Hagihara A, Fujii H, Uchida-Kobayashi S, Tanaka S, Takemura S, Iwaisako K, Enomoto M, Taguchi YH, Tamori A, Kubo S, Ikeda K, Kawada N. Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21. FEBS Open Bio. 2022 Dec;12(12):2122-2135. doi: 10.1002/2211-5463.13489. Epub 2022 Sep 26. PMID:36114826; PMCID: PMC9714377.
3: Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N. Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms. Sci Adv. 2022 Sep 30;8(39):eabo5525. doi:10.1126/sciadv.abo5525. Epub 2022 Sep 28. PMID: 36170363; PMCID: PMC9519040.
4: Yoshizato K, Taira T, Sato-Matsubara M, Sekiguchi S, Yabunaka Y, Kira Y, Ohashi T, Daikoku A, Ofusa K, Kadono C, Oikawa D, Matsubara T, Nakagama Y, Kido Y, Tokunaga F, Ikeda K, Kaneko A, Kawada N. Cloaking the ACE2 receptor with salivary cationic proteins inhibits SARS-CoV-2 entry. J Biochem. 2022 Sep 30;172(4):205-216. doi: 10.1093/jb/mvac054. PMID: 35792074; PMCID: PMC9278198.
5: Okina Y, Sato-Matsubara M, Kido Y, Urushima H, Daikoku A, Kadono C, Nakagama Y, Nitahara Y, Hoang TH, Thuy LTT, Matsubara T, Ohtani N, Ikeda K, Yoshizato K, Kawada N. Nitric oxide derived from cytoglobin-deficient hepatic stellate cells causes suppression of cytochrome c oxidase activity in hepatocytes. Antioxid Redox Signal. 2022 Sep 16. doi: 10.1089/ars.2021.0279. Epub ahead of print. PMID: 36112670.
6: Urushima H, Yuasa H, Matsubara T, Kuroda N, Hara Y, Inoue K, Wake K, Sato T, Friedman SL, Ikeda K. Activation of Hepatic Stellate Cells Requires Dissociation of E-Cadherin-Containing Adherens Junctions with Hepatocytes. Am J Pathol. 2021 Mar;191(3):438-453. doi: 10.1016/j.ajpath.2020.12.007. Epub 2020 Dec 18. PMID: 33345995; PMCID: PMC7919856.
7: Takada S, Matsubara T, Fujii H, Sato-Matsubara M, Daikoku A, Odagiri N, Amano-Teranishi Y, Kawada N, Ikeda K. Stress can attenuate hepatic lipid accumulation via elevation of hepatic β-muricholic acid levels in mice with nonalcoholic steatohepatitis. Lab Invest. 2021 Feb;101(2):193-203. doi: 10.1038/s41374-020-00509-x. Epub 2020 Dec 10. PMID: 33303970.
8: Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K, Thanh Thuy LT, Ichikawa H, Minamiyama Y, Kadota M, Fujii H, Enomoto M, Ikeda K, Yoshizato K, Pinzani M, Kawada N. TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. J Hepatol. 2020 Oct;73(4):882-895. doi: 10.1016/j.jhep.2020.03.051. Epub 2020 Apr 21. PMID: 32330605.
9: Odagiri N, Matsubara T, Higuchi M, Takada S, Urushima H, Sato-Matsubara M, Teranishi Y, Yoshizato K, Kawada N, Ikeda K. Involvement of ERK1/2 activation in the gene expression of senescence-associated secretory factors in human hepatic stellate cells. Mol Cell Biochem. 2019 May;455(1-2):7-19. doi: 10.1007/s11010-018-3466-x. Epub 2018 Nov 13. PMID: 30426301.
10: Sato-Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, Thuy LTT, Adachi J, Tomonaga T, Ikeda K, Yoshizato K, Pinzani M, Kawada N. Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling. J Biol Chem. 2017 Nov 17;292(46):18961-18972. doi: 10.1074/jbc.M117.793794. Epub 2017 Sep 15. PMID: 28916723; PMCID: PMC5706471.
11: Murakami Y, Kubo S, Tamori A, Itami S, Kawamura E, Iwaisako K, Ikeda K, Kawada N, Ochiya T, Taguchi YH. Comprehensive analysis of transcriptome and metabolome analysis in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma. Sci Rep. 2015 Nov 5;5:16294. doi: 10.1038/srep16294. PMID: 26538415; PMCID: PMC4633735.
12: Teranishi Y, Matsubara T, Krausz KW, Le TT, Gonzalez FJ, Yoshizato K, Ikeda K, Kawada N. Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism. Lab Invest. 2015 May;95(5):515-24. doi: 10.1038/labinvest.2015.29. Epub 2015 Feb 16. PMID: 25686096; PMCID: PMC6331008.
13: Kawasaki K, Ushioda R, Ito S, Ikeda K, Masago Y, Nagata K. Deletion of the collagen-specific molecular chaperone Hsp47 causes endoplasmic reticulum stress-mediated apoptosis of hepatic stellate cells. J Biol Chem. 2015 Feb 6;290(6):3639-46. doi: 10.1074/jbc.M114.592139. Epub 2014 Dec 18. PMID: 25525267; PMCID: PMC4319029.
14: Nagamoto Y, Takayama K, Tashiro K, Tateno C, Sakurai F, Tachibana M, Kawabata K, Ikeda K, Tanaka Y, Mizuguchi H. Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene. Cell Transplant. 2015;24(6):1127-38. doi: 10.3727/096368914X681702. Epub 2014 May 6. PMID: 24806294.
15: Saito S, Hata K, Iwaisako K, Yanagida A, Takeiri M, Tanaka H, Kageyama S, Hirao H, Ikeda K, Asagiri M, Uemoto S. Cilostazol attenuates hepatic stellate cell activation and protects mice against carbon tetrachloride-induced liver fibrosis. Hepatol Res. 2014 Apr;44(4):460-73. doi: 10.1111/hepr.12140. Epub 2013 Jun 30. PMID: 23607402.
16: Matsubara T, Tanaka N, Sato M, Kang DW, Krausz KW, Flanders KC, Ikeda K, Luecke H, Wakefield LM, Gonzalez FJ. TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury. J Lipid Res. 2012 Dec;53(12):2698-707. doi: 10.1194/jlr.M031773. Epub 2012 Oct 3. PMID: 23034213; PMCID: PMC3494264.
17: Ogawa T, Enomoto M, Fujii H, Sekiya Y, Yoshizato K, Ikeda K, Kawada N. MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis. Gut. 2012 Nov;61(11):1600-9. doi: 10.1136/gutjnl-2011-300717. Epub 2012 Jan 20. PMID: 22267590.
18: Iizuka M, Ogawa T, Enomoto M, Motoyama H, Yoshizato K, Ikeda K, Kawada N. Induction of microRNA-214-5p in human and rodent liver fibrosis. Fibrogenesis Tissue Repair. 2012 Aug 1;5(1):12. doi: 10.1186/1755-1536-5-12. PMID: 22849305; PMCID: PMC3488464.
19: Sekiya Y, Ogawa T, Iizuka M, Yoshizato K, Ikeda K, Kawada N. Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation. J Cell Physiol. 2011 Oct;226(10):2535-42. doi: 10.1002/jcp.22598. PMID: 21792910.
20: Sekiya Y, Ogawa T, Yoshizato K, Ikeda K, Kawada N. Suppression of hepatic stellate cell activation by microRNA-29b. Biochem Biophys Res Commun. 2011 Aug 19;412(1):74-9. doi: 10.1016/j.bbrc.2011.07.041. Epub 2011 Jul 21. PMID: 21798245.
21: Thuy le TT, Morita T, Yoshida K, Wakasa K, Iizuka M, Ogawa T, Mori M, Sekiya Y, Momen S, Motoyama H, Ikeda K, Yoshizato K, Kawada N. Promotion of liver and lung tumorigenesis in DEN-treated cytoglobin-deficient mice. Am J Pathol. 2011 Aug;179(2):1050-60. doi: 10.1016/j.ajpath.2011.05.006. Epub 2011 Jun 2. PMID: 21684245; PMCID: PMC3157247.
22: Miyaki T, Nojiri S, Shinkai N, Kusakabe A, Matsuura K, Iio E, Takahashi S, Yan G, Ikeda K, Joh T. Pitavastatin inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model rats. Hepatol Res. 2011 Apr;41(4):375-85. doi: 10.1111/j.1872-034X.2010.00769.x. Epub 2011 Jan 30. PMID: 21276150.
23: Ozawa T, Tsuruta D, Jones JC, Ishii M, Ikeda K, Harada T, Aoyama Y, Kawada A, Kobayashi H. Dynamic relationship of focal contacts and hemidesmosome protein complexes in live cells. J Invest Dermatol. 2010 Jun;130(6):1624-35. doi: 10.1038/jid.2009.439. Epub 2010 Jan 28. PMID: 20107487; PMCID: PMC2882194.
24: Imanishi H, Tsuruta D, Tateishi C, Sugawara K, Paus R, Tsuji T, Ishii M, Ikeda K, Kunimoto H, Nakajima K, Jones JC, Kobayashi H. Laminin-511, inducer of hair growth, is down-regulated and its suppressor in hair growth, laminin-332 up-regulated in chemotherapy-induced alopecia. J Dermatol Sci. 2010 Apr;58(1):43-54. doi: 10.1016/j.jdermsci.2010.02.005. Epub 2010 Feb 16. Erratum in: J Dermatol Sci. 2010 Oct;60(1):58. PMID: 20211547; PMCID: PMC2864493.
25: Ogawa T, Iizuka M, Sekiya Y, Yoshizato K, Ikeda K, Kawada N. Suppression of type I collagen production by microRNA-29b in cultured human stellate cells. Biochem Biophys Res Commun. 2010 Jan 1;391(1):316-21. doi: 10.1016/j.bbrc.2009.11.056. Epub 2009 Nov 12. PMID: 19913496.
26: Higashiyama R, Moro T, Nakao S, Mikami K, Fukumitsu H, Ueda Y, Ikeda K, Adachi E, Bou-Gharios G, Okazaki I, Inagaki Y. Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice. Gastroenterology. 2009 Oct;137(4):1459-66.e1. doi: 10.1053/j.gastro.2009.07.006. Epub 2009 Jul 29. PMID: 19596008.
27: Ogawa T, Kawada N, Ikeda K. Effect of natural interferon α on proliferation and apoptosis of hepatic stellate cells. Hepatol Int. 2009 Sep;3(3):497-503. doi: 10.1007/s12072-009-9129-y. Epub 2009 Apr 21. PMID: 19669254; PMCID: PMC2748375.
28: Shinozaki M, Okada Y, Kitano A, Ikeda K, Saika S, Shinozaki M. Impaired cutaneous wound healing with excess granulation tissue formation in TNFalpha- null mice. Arch Dermatol Res. 2009 Aug;301(7):531-7. doi: 10.1007/s00403-009-0969-z. Epub 2009 Jun 20. PMID: 19543902.
29: Otogawa K, Ogawa T, Shiga R, Ikeda K, Kawada N. Induction of tropomyosin during hepatic stellate cell activation and the progression of liver fibrosis. Hepatol Int. 2009 Jun;3(2):378-83. doi: 10.1007/s12072-008-9113-y. Epub 2008 Dec 10. PMID: 19669364; PMCID: PMC2716761.
30: Saika S, Yamanaka O, Okada Y, Tanaka S, Miyamoto T, Sumioka T, Kitano A, Shirai K, Ikeda K. TGF beta in fibroproliferative diseases in the eye. Front Biosci (Schol Ed). 2009 Jun 1;1(1):376-90. doi: 10.2741/S32. PMID: 19482708.
31: Yamanaka O, Miyazaki K, Kitano A, Saika S, Nakajima Y, Ikeda K. Suppression of injury-induced conjunctiva scarring by peroxisome proliferator-activated receptor gamma gene transfer in mice. Invest Ophthalmol Vis Sci. 2009 Jan;50(1):187-93. doi: 10.1167/iovs.08-2282. Epub 2008 Jul 24. PMID: 18658087.
32: Kitano A, Yamanaka O, Ikeda K, Ishida-Nishikawa I, Okada Y, Shirai K, Saika S. Tetrandrine suppresses activation of human subconjunctival fibroblasts in vitro. Curr Eye Res. 2008 Jul;33(7):559-65. doi: 10.1080/02713680802220817. PMID: 18600488.
33: Sakabe M, Sakata H, Matsui H, Ikeda K, Yamagishi T, Nakajima Y. ROCK1 expression is regulated by TGFbeta3 and ALK2 during valvuloseptal endocardial cushion formation. Anat Rec (Hoboken). 2008 Jul;291(7):845-57. doi: 10.1002/ar.20708. PMID: 18461597.
34: Miyazaki K, Okada Y, Yamanaka O, Kitano A, Ikeda K, Kon S, Uede T, Rittling SR, Denhardt DT, Kao WW, Saika S. Corneal wound healing in an osteopontin-deficient mouse. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1367-75. doi: 10.1167/iovs.07-1007. PMID: 18385052.
35: Saika S, Yamanaka O, Flanders KC, Okada Y, Miyamoto T, Sumioka T, Shirai K, Kitano A, Miyazaki K, Tanaka S, Ikeda K. Epithelial-mesenchymal transition as a therapeutic target for prevention of ocular tissue fibrosis. Endocr Metab Immune Disord Drug Targets. 2008 Mar;8(1):69-76. doi: 10.2174/187153008783928343. PMID: 18393925.
36: Matsui H, Sakabe M, Sakata H, Yanagawa N, Ikeda K, Yamagishi T, Nakajima Y. Induction of initial heart alpha-actin, smooth muscle alpha-actin, in chick pregastrula epiblast: the role of hypoblast and fibroblast growth factor-8. Dev Growth Differ. 2008 Mar;50(3):143-57. doi: 10.1111/j.1440-169X.2008.00987.x. Epub 2008 Feb 27. PMID: 18312428.
37: Saika S, Yamanaka O, Sumioka T, Miyamoto T, Miyazaki K, Okada Y, Kitano A, Shirai K, Tanaka S, Ikeda K. Fibrotic disorders in the eye: targets of gene therapy. Prog Retin Eye Res. 2008 Mar;27(2):177-96. doi: 10.1016/j.preteyeres.2007.12.002. Epub 2008 Feb 1. PMID: 18243038.
38: Otogawa K, Ogawa T, Shiga R, Nakatani K, Ikeda K, Nakajima Y, Kawada N. Attenuation of acute and chronic liver injury in rats by iron-deficient diet. Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R311-20. doi: 10.1152/ajpregu.00735.2007. Epub 2007 Nov 21. PMID: 18032466.
39: Sumioka T, Ikeda K, Okada Y, Yamanaka O, Kitano A, Saika S. Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium. Mol Vis. 2008;14:2272-81. Epub 2008 Dec 11. PMID: 19081766; PMCID: PMC2600488.
40: Yamanaka O, Saika S, Ikeda K, Miyazaki K, Kitano A, Ohnishi Y. Connective tissue growth factor modulates extracellular matrix production in human subconjunctival fibroblasts and their proliferation and migration in vitro. Jpn J Ophthalmol. 2008 Jan-Feb;52(1):8-15. doi: 10.1007/s10384-007-0497-3. Epub 2008 Mar 28. PMID: 18369694.
41: Kitano A, Saika S, Yamanaka O, Ikeda K, Okada Y, Shirai K, Reinach PS. Emodin suppression of ocular surface inflammatory reaction. Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5013-22. doi: 10.1167/iovs.07-0393. PMID: 17962452.
42: Yamanaka O, Saika S, Ohnishi Y, Kim-Mitsuyama S, Kamaraju AK, Ikeda K. Inhibition of p38MAP kinase suppresses fibrogenic reaction in conjunctiva in mice. Mol Vis. 2007 Sep 18;13:1730-9. PMID: 17960111.
43: Okada Y, Ikeda K, Yamanaka O, Miyamoto T, Kitano A, Kao WW, Saika S. TNFalpha suppression of corneal epithelium migration. Mol Vis. 2007 Aug 14;13:1428-35. PMID: 17768379.
44: Saika S, Yamanaka O, Okada Y, Miyamoto T, Kitano A, Flanders KC, Ohnishi Y, Nakajima Y, Kao WW, Ikeda K. Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice. Am J Physiol Cell Physiol. 2007 Jul;293(1):C75-86. doi: 10.1152/ajpcell.00332.2006. PMID: 17625041.
45: Fujita S, Saika S, Kao WW, Fujita K, Miyamoto T, Ikeda K, Nakajima Y, Ohnishi Y. Endogenous TNFalpha suppression of neovascularization in corneal stroma in mice. Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3051-5. doi: 10.1167/iovs.06-1083. PMID: 17591872.
46: Saika S, Yamanaka O, Nishikawa-Ishida I, Kitano A, Flanders KC, Okada Y, Ohnishi Y, Nakajima Y, Ikeda K. Effect of Smad7 gene overexpression on transforming growth factor beta-induced retinal pigment fibrosis in a proliferative vitreoretinopathy mouse model. Arch Ophthalmol. 2007 May;125(5):647-54. doi: 10.1001/archopht.125.5.647. PMID: 17502504.
47: Kinoshita K, Iimuro Y, Otogawa K, Saika S, Inagaki Y, Nakajima Y, Kawada N, Fujimoto J, Friedman SL, Ikeda K. Adenovirus-mediated expression of BMP-7 suppresses the development of liver fibrosis in rats. Gut. 2007 May;56(5):706-14. doi: 10.1136/gut.2006.092460. Epub 2006 Nov 24. PMID: 17127702; PMCID: PMC1942155.
48: El-Karef A, Kaito M, Tanaka H, Ikeda K, Nishioka T, Fujita N, Inada H, Adachi Y, Kawada N, Nakajima Y, Imanaka-Yoshida K, Yoshida T. Expression of large tenascin-C splice variants by hepatic stellate cells/myofibroblasts in chronic hepatitis C. J Hepatol. 2007 Apr;46(4):664-73. doi: 10.1016/j.jhep.2006.10.011. Epub 2006 Nov 27. PMID: 17188391.
49: Otogawa K, Kinoshita K, Fujii H, Sakabe M, Shiga R, Nakatani K, Ikeda K, Nakajima Y, Ikura Y, Ueda M, Arakawa T, Hato F, Kawada N. Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. Am J Pathol. 2007 Mar;170(3):967-80. doi: 10.2353/ajpath.2007.060441. PMID: 17322381; PMCID: PMC1864892.
50: Kinoshita K, Iimuro Y, Fujimoto J, Inagaki Y, Namikawa K, Kiyama H, Nakajima Y, Otogawa K, Kawada N, Friedman SL, Ikeda K. Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre/loxP system to antagonise hepatic fibrosis. Gut. 2007 Mar;56(3):396-404. doi: 10.1136/gut.2005.085704. Epub 2006 Sep 6. PMID: 16956920; PMCID: PMC1856807.
51: Sakata H, Sakabe M, Matsui H, Kawada N, Nakatani K, Ikeda K, Yamagishi T, Nakajima Y. Rho kinase inhibitor Y27632 affects initial heart myofibrillogenesis in cultured chick blastoderm. Dev Dyn. 2007 Feb;236(2):461-72. doi: 10.1002/dvdy.21055. PMID: 17195179.
52: Sugawara K, Tsuruta D, Kobayashi H, Ikeda K, Hopkinson SB, Jones JC, Ishii M. Spatial and temporal control of laminin-332 (5) and -511 (10) expression during induction of anagen hair growth. J Histochem Cytochem. 2007 Jan;55(1):43-55. doi: 10.1369/jhc.6A6920.2006. Epub 2006 Sep 6. PMID: 16957169; PMCID: PMC3046633.
53: Sakabe M, Abe M, Nakatani K, Ikeda K, Yoshiyamal M, Nakajima Y. [Dissection of the heart: a useful guide to understanding the three-dimensional gross anatomy]. Kaibogaku Zasshi. 2006 Dec;81(4):117-24. Japanese. PMID: 17191690.
54: Matsui H, Sakabe M, Sakata H, Nakatani K, Ikeda K, Fukui M, Ando K, Yamagishi T, Nakajima Y. Heart myofibrillogenesis occurs in isolated chick posterior blastoderm: a culture model. Acta Histochem Cytochem. 2006 Oct 30;39(5):139-44. doi: 10.1267/ahc.06009. Epub 2006 Oct 11. PMID: 17327900; PMCID: PMC1698866.
55: Kitano A, Saika S, Yamanaka O, Reinach PS, Ikeda K, Okada Y, Shirai K, Ohnishi Y. Genipin suppression of fibrogenic behaviors of the alpha-TN4 lens epithelial cell line. J Cataract Refract Surg. 2006 Oct;32(10):1727-35. doi: 10.1016/j.jcrs.2006.05.015. PMID: 17010875.
56: Yamanaka O, Ikeda K, Saika S, Miyazaki K, Ooshima A, Ohnishi Y. Gene transfer of Smad7 modulates injury-induced conjunctival wound healing in mice. Mol Vis. 2006 Aug 1;12:841-51. PMID: 16902401.
57: Yamanaka O, Saika S, Ikeda K, Miyazaki K, Ohnishi Y, Ooshima A. Interleukin-7 modulates extracellular matrix production and TGF-beta signaling in cultured human subconjunctival fibroblasts. Curr Eye Res. 2006 Jun;31(6):491-9. doi: 10.1080/02713680600701380. PMID: 16769608.
58: Saika S, Ikeda K, Yamanaka O, Flanders KC, Okada Y, Miyamoto T, Kitano A, Ooshima A, Nakajima Y, Ohnishi Y, Kao WW. Loss of tumor necrosis factor alpha potentiates transforming growth factor beta-mediated pathogenic tissue response during wound healing. Am J Pathol. 2006 Jun;168(6):1848-60. doi: 10.2353/ajpath.2006.050980. PMID: 16723700; PMCID: PMC1606617.
59: Wang YQ, Luk JM, Chu AC, Ikeda K, Man K, Kaneda K, Fan ST. TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB- activated hepatic stellate cells. Biochem Biophys Res Commun. 2006 Mar 3;341(1):239-44. doi: 10.1016/j.bbrc.2005.12.175. Epub 2006 Jan 9. PMID: 16413500.
60: Nakatani K, Tanaka H, Ikeda K, Sakabe M, Kadoya H, Seki S, Kaneda K, Nakajima Y. Expression of NCAM in activated portal fibroblasts during regeneration of the rat liver after partial hepatectomy. Arch Histol Cytol. 2006 Mar;69(1):61-72. doi: 10.1679/aohc.69.61. PMID: 16609270.
61: Kitano A, Saika S, Yamanaka O, Ikeda K, Reinach PS, Nakajima Y, Okada Y, Shirai K, Ohnishi Y. Genipin suppresses subconjunctival fibroblast migration, proliferation and myofibroblast transdifferentiation. Ophthalmic Res. 2006;38(6):355-60. doi: 10.1159/000096231. Epub 2006 Oct 13. PMID: 17047408.
62: Sakabe M, Ikeda K, Nakatani K, Kawada N, Imanaka-Yoshida K, Yoshida T, Yamagishi T, Nakajima Y. Rho kinases regulate endothelial invasion and migration during valvuloseptal endocardial cushion tissue formation. Dev Dyn. 2006 Jan;235(1):94-104. doi: 10.1002/dvdy.20648. PMID: 16342113.
63: Izumi N, Mizuguchi S, Inagaki Y, Saika S, Kawada N, Nakajima Y, Inoue K, Suehiro S, Friedman SL, Ikeda K. BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2. Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L120-6. doi: 10.1152/ajplung.00171.2005. Epub 2005 Aug 26. PMID: 16126788.
64: Saika S, Ikeda K, Yamanaka O, Flanders KC, Ohnishi Y, Nakajima Y, Muragaki Y, Ooshima A. Adenoviral gene transfer of BMP-7, Id2, or Id3 suppresses injury-induced epithelial-to-mesenchymal transition of lens epithelium in mice. Am J Physiol Cell Physiol. 2006 Jan;290(1):C282-9. doi: 10.1152/ajpcell.00306.2005. Epub 2005 Aug 24. PMID: 16120655.
65: Matsui H, Ikeda K, Nakatani K, Sakabe M, Yamagishi T, Nakanishi T, Nakajima Y. Induction of initial cardiomyocyte alpha-actin--smooth muscle alpha-actin—in cultured avian pregastrula epiblast: a role for nodal and BMP antagonist. Dev Dyn. 2005 Aug;233(4):1419-29. doi: 10.1002/dvdy.20477. PMID: 15977172.
66: Inagaki Y, Kushida M, Higashi K, Itoh J, Higashiyama R, Hong YY, Kawada N, Namikawa K, Kiyama H, Bou-Gharios G, Watanabe T, Okazaki I, Ikeda K. Cell type-specific intervention of transforming growth factor beta/Smad signaling suppresses collagen gene expression and hepatic fibrosis in mice. Gastroenterology. 2005 Jul;129(1):259-68. doi: 10.1053/j.gastro.2005.03.088. PMID: 16012952.
67: Saika S, Yamanaka O, Ikeda K, Kim-Mitsuyama S, Flanders KC, Yoo J, Roberts AB, Nishikawa-Ishida I, Ohnishi Y, Muragaki Y, Ooshima A. Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells. Lab Invest. 2005 Jul;85(7):838-50. doi: 10.1038/labinvest.3700294. PMID: 15924151.
68: Saika S, Ikeda K, Yamanaka O, Miyamoto T, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Nakajima Y, Kao WW, Flanders KC, Roberts AB. Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali. Am J Pathol. 2005 May;166(5):1405-18. doi: 10.1016/S0002-9440(10)62358-9. PMID: 15855641; PMCID: PMC1606395.
69: Saika S, Miyamoto T, Yamanaka O, Kato T, Ohnishi Y, Flanders KC, Ikeda K, Nakajima Y, Kao WW, Sato M, Muragaki Y, Ooshima A. Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice. Am J Pathol. 2005 May;166(5):1393-403. doi: 10.1016/s0002-9440(10)62357-7. PMID: 15855640; PMCID: PMC1606394.
70: Saika S, Ikeda K, Yamanaka O, Flanders KC, Nakajima Y, Miyamoto T, Ohnishi Y, Kao WW, Muragaki Y, Ooshima A. Therapeutic effects of adenoviral gene transfer of bone morphogenic protein-7 on a corneal alkali injury model in mice. Lab Invest. 2005 Apr;85(4):474-86. doi: 10.1038/labinvest.3700247. PMID: 15696184.
71: Yamamoto S, Okuda T, Yamasaki K, Tanaka H, Kubo S, Takemura S, Ikeda K, Minamiyama Y, Hirohashi K, Suehiro S. FK778 and FK506 combination therapy to control acute rejection after rat liver allotransplantation. Transplantation. 2004 Dec 15;78(11):1618-25. doi: 10.1097/01.tp.0000144312.08782.16. PMID: 15591950.
72: Saika S, Ikeda K, Yamanaka O, Sato M, Muragaki Y, Ohnishi Y, Ooshima A, Nakajima Y, Namikawa K, Kiyama H, Flanders KC, Roberts AB. Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice. Lab Invest. 2004 Oct;84(10):1259-70. doi: 10.1038/labinvest.3700151. PMID: 15258599.
73: Matsui H, Ikeda K, Nakajima Y, Horikawa S, Imanishi Y, Kawada N. Sulfur-containing amino acids attenuate the development of liver fibrosis in rats through down-regulation of stellate cell activation. J Hepatol. 2004 Jun;40(6):917-25. doi: 10.1016/j.jhep.2004.02.011. PMID: 15158331.
74: Wang YQ, Luk JM, Ikeda K, Man K, Chu AC, Kaneda K, Fan ST. Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells. Biochem Biophys Res Commun. 2004 Apr 30;317(2):358-62. doi: 10.1016/j.bbrc.2004.03.050. PMID: 15063765.
75: Maeda N, Kawada N, Seki S, Ikeda K, Okuyama H, Hirabayashi J, Kasai KI, Yoshizato K. Involvement of Galectin-1 and Galectin-3 in Proliferation and Migration of Rat Hepatic Stellate Cells in Culture. Comp Hepatol. 2004 Jan 14;3 Suppl 1(Suppl 1):S10. doi: 10.1186/1476-5926-2-S1-S10. PMID: 14960162; PMCID: PMC2410233.
76: Fujii H, Seki S, Nakatani K, Ikeda K, Ikemoto M, Nakajima Y, Arakawa T, Kaneda K. Localization of lymphocyte apoptosis in murine lymphoid tissues after stimulation of natural killer T cells with alpha-galactosylceramide. Arch Histol Cytol. 2003 Dec;66(5):397-406. doi: 10.1679/aohc.66.397. PMID: 15018142.
77: Uyama N, Shimahara Y, Okuyama H, Kawada N, Kamo S, Ikeda K, Yamaoka Y. Carbenoxolone inhibits DNA synthesis and collagen gene expression in rat hepatic stellate cells in culture. J Hepatol. 2003 Nov;39(5):749-55. doi: 10.1016/s0168-8278(03)00375-1. PMID: 14568257.
78: Inagaki Y, Nemoto T, Kushida M, Sheng Y, Higashi K, Ikeda K, Kawada N, Shirasaki F, Takehara K, Sugiyama K, Fujii M, Yamauchi H, Nakao A, de Crombrugghe B, Watanabe T, Okazaki I. Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice. Hepatology. 2003 Oct;38(4):890-9. doi: 10.1053/jhep.2003.50408. PMID: 14512876.
79: Maeda N, Kawada N, Seki S, Arakawa T, Ikeda K, Iwao H, Okuyama H, Hirabayashi J, Kasai K, Yoshizato K. Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways. J Biol Chem. 2003 May 23;278(21):18938-44. doi: 10.1074/jbc.M209673200. Epub 2003 Mar 19. PMID: 12646584.
80: Sato EF, Higashino M, Ikeda K, Wake R, Matsuo M, Utsumi K, Inoue M. Oxidative stress-induced cell death of human oral neutrophils. Am J Physiol Cell Physiol. 2003 Apr;284(4):C1048-53. doi: 10.1152/ajpcell.00016.2002. Epub 2002 Dec 18. PMID: 12490433.
81: Kobayashi S, Seki S, Kawada N, Morikawa H, Nakatani K, Uyama N, Ikeda K, Nakajima Y, Arakawa T, Kaneda K. Apoptosis of T cells in the hepatic fibrotic tissue of the rat: a possible inducing role of hepatic myofibroblast-like cells. Cell Tissue Res. 2003 Mar;311(3):353-64. doi: 10.1007/s00441-002-0670-4. Epub 2003 Feb 5. PMID: 12658443.
82: Nakatani K, Seki S, Kawada N, Kitada T, Yamada T, Sakaguchi H, Kadoya H, Ikeda K, Kaneda K. Expression of SPARC by activated hepatic stellate cells and its correlation with the stages of fibrogenesis in human chronic hepatitis. Virchows Arch. 2002 Nov;441(5):466-74. doi: 10.1007/s00428-002-0631-z. Epub 2002 Apr 26. PMID: 12447677.
83: Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng FJ, Labrador P, Klein R, Lovett D, Yancopoulos GD, Friedman SL, Lin HC. Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen. J Biol Chem. 2002 May 24;277(21):19206-12. doi: 10.1074/jbc.M201078200. Epub 2002 Mar 7. PMID: 11884411.
84: Saxena NK, Ikeda K, Rockey DC, Friedman SL, Anania FA. Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology. 2002 Apr;35(4):762-71. doi: 10.1053/jhep.2002.32029. PMID: 11915021; PMCID: PMC2935193.
85: Olaso E, Labrador JP, Wang L, Ikeda K, Eng FJ, Klein R, Lovett DH, Lin HC, Friedman SL. Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2. J Biol Chem. 2002 Feb 1;277(5):3606-13. doi: 10.1074/jbc.M107571200. Epub 2001 Nov 26. PMID: 11723120.
86: Olaso E, Ikeda K, Eng FJ, Xu L, Wang LH, Lin HC, Friedman SL. DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. J Clin Invest. 2001 Nov;108(9):1369-78. doi: 10.1172/JCI12373. PMID: 11696582; PMCID: PMC209436.
87: Kadoya H, Ikeda K, Nakatani K, Seki S, Kaneda K. Cellular prion protein expression in non-ciliated epithelial cells (Clara cells) of proliferating bronchioles during bleomycin-induced pulmonary fibrosis in hamster. Osaka City Med J. 2001 Jun;47(1):23-32. PMID: 11556389.
88: Okuno M, Akita K, Moriwaki H, Kawada N, Ikeda K, Kaneda K, Suzuki Y, Kojima S. Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta. Gastroenterology. 2001 Jun;120(7):1784-800. doi: 10.1053/gast.2001.24832. PMID: 11375959.
89: Shimizu S, Yamada N, Sawada T, Ikeda K, Nakatani K, Seki S, Kaneda K, Hirakawa K. Ultrastructure of early phase hepatic metastasis of human colon carcinoma cells with special reference to desmosomal junctions with hepatocytes. Pathol Int. 2000 Dec;50(12):953-9. doi: 10.1046/j.1440-1827.2000.01153.x. PMID: 11123761.
90: Shimizu S, Yamada N, Sawada T, Ikeda K, Kawada N, Seki S, Kaneda K, Hirakawa K. In vivo and in vitro interactions between human colon carcinoma cells and hepatic stellate cells. Jpn J Cancer Res. 2000 Dec;91(12):1285-95. doi: 10.1111/j.1349-7006.2000.tb00916.x. PMID: 11123428; PMCID: PMC5926299.
91: Kitada T, Seki S, Ikeda K, Nakatani K, Sakaguchi H, Kawada N, Kadoya H, Kaneda K. Clinicopathological characterization of prion: a novel marker of activated human hepatic stellate cells. J Hepatol. 2000 Nov;33(5):751-7. doi: 10.1016/s0168-8278(00)80306-2. PMID: 11097483.
92: Wang YQ, Ikeda K, Ikebe T, Hirakawa K, Sowa M, Nakatani K, Kawada N, Kaneda K. Inhibition of hepatic stellate cell proliferation and activation by the semisynthetic analogue of fumagillin TNP-470 in rats. Hepatology. 2000 Nov;32(5):980-9. doi: 10.1053/jhep.2000.18658. PMID: 11050048.
93: Yachida S, Ikeda K, Kaneda K, Goda F, Maeba T, Maeta H. Preventive effect of preoperative portal vein ligation on endotoxin-induced hepatic failure in hepatectomized rats is associated with reduced tumour necrosis factor alpha production. Br J Surg. 2000 Oct;87(10):1382-90. doi: 10.1046/j.1365-2168.2000.01535.x. PMID: 11044165.
94: Yamasaki M, Ikeda K, Nakatani K, Yamamoto T, Kawai Y, Hirohashi K, Kinoshita H, Kaneda K. Phenotypical and morphological alterations to rat sinusoidal endothelial cells in arterialized livers after portal branch ligation. Arch Histol Cytol. 1999 Dec;62(5):401-11. doi: 10.1679/aohc.62.401. PMID: 10678569.
95: Kawada N, Ikeda K, Seki S, Kuroki T. Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture. J Hepatol. 1999 Jun;30(6):1057-64. doi: 10.1016/s0168-8278(99)80260-8. PMID: 10406184.
96: Ikeda K, Wakahara T, Wang YQ, Kadoya H, Kawada N, Kaneda K. In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation. Hepatology. 1999 Jun;29(6):1760-7. doi: 10.1002/hep.510290640. PMID: 10347119.
97: Ikeda K, Kawada N, Wang YQ, Kadoya H, Nakatani K, Sato M, Kaneda K. Expression of cellular prion protein in activated hepatic stellate cells. Am J Pathol. 1998 Dec;153(6):1695-700. doi: 10.1016/S0002-9440(10)65683-0. PMID: 9846959; PMCID: PMC1866339.
98: Tsuji N, Kawada N, Ikeda K, Kinoshita H, Kaneda K. Immunohistochemical and ultrastructural analyses of in situ activation of hepatic stellate cells around Propionibacterium acnes-induced granulomas in the rat liver. J Submicrosc Cytol Pathol. 1997 Jan;29(1):125-33. PMID: 9066151.
99: Kawada N, Harada K, Ikeda K, Kaneda K. Morphological study of endothelin-1-induced contraction of cultured hepatic stellate cells on hydrated collagen gels. Cell Tissue Res. 1996 Dec;286(3):477-86. doi: 10.1007/s004410050717. PMID: 8929350.
100: Ikeda K, Kubo S, Hirohashi K, Kinoshita H, Kaneda K, Kawada N, Sato EF, Inoue M. Mechanism that regulates nitric oxide production by lipopolysaccharide- stimulated rat Kupffer cells. Physiol Chem Phys Med NMR. 1996;28(4):239-53.
PMID: 9153798.
101: Ikeda K, Kinoshita H, Hirohashi K, Kubo S, Kaneda K. The ultrastructure, kinetics and intralobular distribution of apoptotic hepatocytes after portal branch ligation with special reference to their relationship to necrotic hepatocytes. Arch Histol Cytol. 1995 Jun;58(2):171-84. doi: 10.1679/aohc.58.171. PMID: 7576869.
102: Takei Y, Kawano S, Nishimura Y, Goto M, Nagai H, Chen SS, Omae A, Fusamoto H, Kamada T, Ikeda K, et al. Apoptosis: a new mechanism of endothelial and Kupffer cell killing. J Gastroenterol Hepatol. 1995;10 Suppl 1:S65-7. doi: 10.1111/j.1440-1746.1995.tb01802.x. PMID: 8589347.
103: Shuto T, Kinoshita H, Hirohashi K, Kubo S, Fujio N, Tanaka H, Horii K, Hamba H, Takemura S, Ikeda K, et al. [Second resected hepatocellular carcinoma of multicentric occurrence suspected by clinical follow-up]. Nihon Shokakibyo Gakkai Zasshi. 1993 Jun;90(6):1516-20. Japanese. PMID: 8392635.