プロフィール：准教授（兼任）　宇留島 隼人

准教授（兼任）　宇留島 隼人

　

准教授（兼任）　宇留島 隼人

Lecturer: URUSHIMA, Hayato

urushima.hayato(at)omu.ac.jp

自己紹介

光学顕微鏡や電子顕微鏡などで観察された組織や細胞の「形態・構造」の変化が、どのような「機能」変化と相関しているのかを分子生物学的に解明し、従来の創薬研究とは違う角度から候補分子を見つけたいと考えています。また、さまざまな疾患モデルマウスを用いて、病態改善能が期待できる食品由来成分を探索しています。

 

略歴
2004年3月 鳥取大学農学部獣医学科卒業
2004年4月～2010年10月　臨床獣医師として小動物臨床に従事
2015年3月 大阪大学大学院医学系研究科修了　博士（医学）
2015年4月 国立研究開発法人医薬基盤・健康・栄養研究所　博士研究員
2016年10月 大阪市立大学大学院医学研究科　助教
2021年7月 大阪公立大学大学院医学研究科　講師
2022年4月 大阪公立大学医学部動物実験施設実験動物管理者（兼任）
2017年度 大阪市立大学医学部　Teacher of the year受賞
2023年度 大阪公立大学医学部　Teacher of the year受賞

 

主な研究業績

和文

  1. 【肝星細胞活性化と肝硬変・肝がん】肝星細胞活性化の新規initiation factor

細胞（ニュー・サイエンス社）, 第51巻 第11号, pp.526-529, 2019年

宇留島隼人・池田一雄

 

  1. 肝星細胞と肝細胞の「構造―機能相関」

肝胆膵（アークメデイア社）, 第82巻 第4号pp.593-600, 2021年

宇留島隼人・池田一雄

 

英文

  1. Poorly Differentiated Hepatocellular Carcinoma Cells Avoid Apoptosis by Interacting with T Cells via CD40-CD40L Linkage.
    Hanh NV, Thuy LTT, Hieu VN, Hai H, Ikenaga H, Sato-Matsubara M, Uchida-Kobayashi S, Urushima H, Khanh NV, Ha NT, Shinkawa H, Kubo S, Ohtani N, Enomoto M, Tamori A, Kawada N.
    Am J Pathol. 2024 Mar 26:S0002-9440(24)00117-2. doi: 10.1016/j.ajpath.2024.03.004.
  1. Hypo-osmolarity induces apoptosis resistance via TRPV2-mediated AKT-Bcl-2 pathway.

Urushima H, Matsubara T, Miyakoshi M, Kimura S, Yuasa H, Yoshizato K, Ikeda K.

Am J Physiol Gastrointest Liver Physiol. 2023 Jan 31. doi: 10.1152/ajpgi.00138.2022.

 

  1. Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21.

Kawamura E, Matsubara T, Daikoku A, Deguchi S, Kinoshita M, Yuasa H, Urushima H, Odagiri N, Motoyama H, Kotani K, Kozuka R, Hagihara A, Fujii H, Uchida-Kobayashi S, Tanaka S, Takemura S, Iwaisako K, Enomoto M, Taguchi YH, Tamori A, Kubo S, Ikeda K, Kawada N.

FEBS Open Bio. 2022 Dec;12(12):2122-2135. doi: 10.1002/2211-5463.13489. Epub 2022 Sep 26. PMID: 36114826

 

  1. Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms.

Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N.

Sci Adv. 2022 Sep 30;8(39):eabo5525. doi: 10.1126/sciadv.abo5525. Epub 2022 Sep 28. PMID: 36170363

 

  1. Nitric oxide derived from cytoglobin-deficient hepatic stellate cells causes suppression of cytochrome c oxidase activity in hepatocytes.

Okina Y, Sato-Matsubara M, Kido Y, Urushima H, Daikoku A, Kadono C, Nakagama Y, Nitahara Y, Hoang TH, Thuy LTT, Matsubara T, Ohtani N, Ikeda K, Yoshizato K, Kawada N.

Antioxid Redox Signal. 2022 Sep 16. doi: 10.1089/ars.2021.0279. PMID: 36112670

 

  1. Soluble Immune Checkpoint Protein CD27 Is a Novel Prognostic Biomarker of Hepatocellular Carcinoma Development in Hepatitis C Virus-Sustained Virological Response Patients.

Dong MP, Thuy LTT, Hoang DV, Hai H, Hoang TH, Sato-Matsubara M, Hieu VN, Daikoku A, Hanh NV, Urushima H, Dat NQ, Uchida-Kobayashi S, Enomoto M, Ohtani N, Tamori A, Kawada N.

Am J Pathol. 2022 Oct;192(10):1379-1396. doi: 10.1016/j.ajpath.2022.07.003. Epub 2022 Aug 11. PMID: 35963463

 

  1. Activation of Hepatic Stellate Cells Requires Dissociation of E-Cadherin-Containing Adherens Junctions with Hepatocytes.

Urushima H, Yuasa H, Matsubara T, Kuroda N, Hara Y, Inoue K, Wake K, Sato T, Friedman SL, Ikeda K.

Am J Pathol. 2021 Mar;191(3):438-453. doi: 10.1016/j.ajpath.2020.12.007. Epub 2020 Dec 18. PMID: 33345995

 

  1. Involvement of ERK1/2 activation in the gene expression of senescence-associated secretory factors in human hepatic stellate cells.

Odagiri N, Matsubara T, Higuchi M, Takada S, Urushima H, Sato-Matsubara M, Teranishi Y, Yoshizato K, Kawada N, Ikeda K.

Mol Cell Biochem. 2019 May;455(1-2):7-19. doi: 10.1007/s11010-018-3466-x. Epub 2018 Nov 13. PMID: 30426301

 

  1. Leucine-rich α-2 glycoprotein promotes lung fibrosis by modulating TGF-β signaling in fibroblasts.

Honda H, Fujimoto M, Serada S, Urushima H, Mishima T, Lee H, Ohkawara T, Kohno N, Hattori N, Yokoyama A, Naka T.

Physiol Rep. 2017 Dec;5(24):e13556. doi: 10.14814/phy2.13556. Epub 2017 Dec 26. PMID: 29279415

 

Urushima H, Fujimoto M, Mishima T, Ohkawara T, Honda H, Lee H, Kawahata H, Serada S, Naka T.

Arthritis Res Ther. 2017 Jun 14;19(1):137. doi: 10.1186/s13075-017-1349-2. PMID: 28615031

 

  1. Efficacy and Interaction of Antioxidant Supplements as Adjuvant Therapy in Cancer Treatment: A Systematic Review.

Yasueda A, Urushima H, Ito T.

Integr Cancer Ther. 2016 Mar;15(1):17-39. doi: 10.1177/1534735415610427. Epub 2015 Oct 26. PMID: 26503419

 

  1. Maltitol Prevents the Progression of Fatty Liver Degeneration in Mice Fed High-Fat Diets.

Urushima H, Sanada Y, Sakaue M, Matsuzawa Y, Ito T, Maeda K.

J Med Food. 2015 Oct;18(10):1081-7. doi: 10.1089/jmf.2014.3380. Epub 2015 May 18. PMID: 26061453

 

  1. The effects of androgen deprivation therapy with weight management on serum aP2 and adiponectin levels in prostate cancer patients.

Urushima H, Inomata-Kurashiki Y, Nishimura K, Sumi R, Shimomura I, Nonomura N, Ito T, Maeda K.

Aging Male. 2015 Jun;18(2):72-6. doi: 10.3109/13685538.2015.1017809. Epub 2015 Mar 9. PMID: 25746209

 

  1. Perilla frutescens extract ameliorates DSS-induced colitis by suppressing proinflammatory cytokines and inducing anti-inflammatory cytokines.

Urushima H, Nishimura J, Mizushima T, Hayashi N, Maeda K, Ito T.

Am J Physiol Gastrointest Liver Physiol. 2015 Jan 1;308(1):G32-41. doi: 10.1152/ajpgi.00294.2014. Epub 2014 Oct 30. PMID: 25359539

 

  1. Reduction of adverse effects by a mushroom product, active hexose correlated compound (AHCC) in patients with advanced cancer during chemotherapy--the significance of the levels of HHV-6 DNA in saliva as a surrogate biomarker during chemotherapy.

Ito T, Urushima H, Sakaue M, Yukawa S, Honda H, Hirai K, Igura T, Hayashi N, Maeda K, Kitagawa T, Kondo K.

Nutr Cancer. 2014;66(3):377-82. doi: 10.1080/01635581.2014.884232. Epub 2014 Mar 10. PMID: 24611562

 

  1. Inhibition of epithelial cell death by Bcl-2 improved chronic colitis in IL-10 KO mice.

Mizushima T, Arakawa S, Sanada Y, Yoshino I, Miyazaki D, Urushima H, Tsujimoto Y, Ito T, Shimizu S.

Am J Pathol. 2013 Dec;183(6):1936-1944. doi: 10.1016/j.ajpath.2013.08.012. PMID: 24266926

 

  1. Phylogenetic relationships of rodent pinworms (genus Syphacia) in Japan inferred from 28S rDNA sequences.

Okamoto M, Urushima H, Hasegawa H.

Parasitol Int. 2009 Dec;58(4):330-3. doi: 10.1016/j.parint.2009.07.001. Epub 2009 Jul 8. PMID: 19591961

 

  1. Phylogenetic relationships of rodent pinworms (genus Syphacia) in Japan inferred from mitochondrial CO1 gene sequences.

Okamoto M, Urushima H, Iwasa M, Hasegawa H.

J Vet Med Sci. 2007 May;69(5):545-7. doi: 10.1292/jvms.69.545. PMID: 17551231