プロフィール：助教　湯浅 秀人

助教　湯浅 秀人

　

助教　湯浅 秀人

Assistant professor: YUASA, Hideto

yuasa.hideto(at)omu.ac.jp

自己紹介

光学顕微鏡および電子顕微鏡を用いた形態学的観点から肝臓の正常構造を解析し、その崩壊がもたらす肝病態への変化について解明しようとしています。

電子顕微鏡はナノスケールの世界を観察するために古くから用いられてきました。近年では技術の発展により三次元的な構造解析までもが可能となっております。これらの技術を駆使して未だ見たことない像を観察することを楽しみに研究を進めています。

 

略歴
2013年3月 神戸大学農学部資源生命科学科　卒業
2018年４月 神戸大学大学院農学研究科　　　修了
2018年４月 大阪市立大学大学院医学研究科　助教

　

主な研究業績

英文

  1. Kawamura E, Matsubara T, Daikoku A, Deguchi S, Kinoshita M, Yuasa H, Urushima H, Odagiri N, Motoyama H, Kotani K, Kozuka R, Hagihara A, Fujii H, Uchida-Kobayashi S, Tanaka S, Takemura S, Iwaisako K, Enomoto M, Taguchi YH, Tamori A, Kubo S, Ikeda K, Kawada N. Suppression of intrahepatic cholangiocarcinoma cell growth by SKI via upregulation of the CDK inhibitor p21. FEBS Open Bio. 12. 2122-2135.

 

  1. Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy LTT, Ikenaga H, Phuong DM, Hanh NV, Hieu VN, Hoang DV, Hai H, Okina Y, Enomoto M, Tamori A, Daikoku A, Urushima H, Ikeda K, Dat NQ, Yasui Y, Shinkawa H, Kubo S, Yamagishi R, Ohtani N, Yoshizato K, Gracia-Sancho J, Kawada N. Cancer cells actively produce liver metastasis via intracellular gap formation in liver sinusoidal endothelial cells through pro-inflammatory paracrine mechanisms. Science Advances 2022 Sep 30;8(39):eabo5525. doi: 10.1126/sciadv.abo5525. Epub 2022 Sep 28.

 

  1. Mantani Y, Haruta T, Nakanishi S, Sakata N, Yuasa H, Yokoyama T, Hoshi N. Ultrastructural and phenotypical diversity of macrophages in the rat ileal mucosa. Cell and Tissue Research. 2021. 385(3):697-711.

 

  1. Urushima H, Yuasa H, Matsubara T, Kuroda N, Hara Y, Inoue K, Wake K, Sato T, Friedman SL, Ikeda K. Activation of Hepatic Stellate Cells Requires Dissociation of E-Cadherin-Containing Adherens Junctions with Hepatocytes. Am J Pathol. 2021. 191(3):438-453.

 

  1. Arai M, Mantani Y, Nakanishi S, Haruta T, Nishida M, Yuasa H, Yokoyama T, Hoshi N, Kitagawa H. Morphological and phenotypical diversity of eosinophils in the rat ileum. Cell and Tissue Research. 381(3):439-450.

 

  1. Yuasa H, Mantani Y, Miyamoto K, Nishida M, Arai M, Tsuruta H, Yokoyama T, Hoshi N, Kitagawa H. Effects of the expansion of bacterial colonies into the intervillous spaces on the localization of several lymphocyte lineages in the rat ileum. J Vet Med Sci. 2019. 81(4):555–566.

 

  1. Masuda N, Mantani Y, Yuasa H, Yoshitomi C, Arai M, Nishida M, Qi WM, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. Immunohistochemical study on the distribution of β-defensin 1 and β-defensin 2 throughout the respiratory tract of healthy rats. J. Vet. Med. Sci. 2018. 80(3): 395–404.

 

  1. Masuda N, Mantani Y, Yoshitomi C, Yuasa H, Nishida M, Arai M, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. Immunohistochemical study on the secretory host defense system with lysozyme and secretory phospholipase A2 throughout rat respiratory tract. J. Vet. Med. Sci. 2018. 80(2): 323–332.

 

  1. Mantani Y, Nishida M, Yamamoto K, Miyamoto K, Yuasa H, Masuda N, Omotehara T, Tsuruta H, Yokoyama T, Hoshi N, Kitagawa H. Ultrastructural and Immunohistochemical Study on the Lamina Propria Cells Beneath Paneth Cells in the Rat Ileum. The Anatomical record. 2018. 301(6): 1074-1085.

 

  1. Yuasa H, Mantani Y, Masuda N, Nishida M, Arai M, Yokoyama T, Tsuruta H, Kawano J, Hoshi N, Kitagawa H. Mechanism of M-cell differentiation accelerated by proliferation of indigenous bacteria in rat Peyer’s patches. J. Vet. Med. Sci. 2017. 79(11): 1826–1835.

 

  1. Yuasa H, Mantani Y, Masuda N, Nishida M, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. Differential expression of Toll-like receptor-2, -4 and -9 in follicle-associated epithelium from epithelia of both follicle-associated intestinal villi and ordinary intestinal villi in rat Peyer's patches. J. Vet. Med. Sci. 2017. 78(12): 1797–1804.

 

  1. Umemura Y, Miyamoto R, Hashimoto R, Kinoshita K, Omotehara T, Nagahara D, Hirano T, Kubota N, Minami K, Yanai S, Masuda N, Yuasa H, Mantani Y, Matsuo E, Yokoyama T, Kitagawa H, Hoshi N. Ontogenic and morphological study of gonadal formation in genetically-modified sex reversal XY(POS) mice. J. Vet. Med. Sci. 2016. 77(12): 1587–1598.

 

  1. Kobayashi Y, Hirano T, Omotehara T, Hashimoto R, Umemura Y, Yuasa H, Masuda N, Kubota N, Minami K, Yanai S, Ishihara-Sugano M, Mantani Y, Yokoyama T, Kitagawa H, Hoshi N. Immunohistochemical analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity on the developmental dentate gyrus and hippocampal fimbria in fetal mice. J. Vet. Med. Sci. 2015. 77(11): 1355–1361.

 

  1. Mantani Y, Ito E, Nishida M, Yuasa H, Masuda N, Qi WM, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. Ultrastructural study on the morphological changes in indigenous bacteria of mucous layer and chyme throughout the rat intestine. J. Vet. Med. Sci. 2015. 77(9): 1121–1128.

 

  1. Takahara E, Yuasa H, Nishida M, Mantani Y, Udayanga KGS, Qi WM, Takeuchi T, Yokoyama T, Hoshi N, Kitagawa H. Immunohistochemical and histoplanimetrical study on the endothelial receptor involved in transportation of minute chylomicrons into subepithelial portal blood in intestinal villi of the rat jejunum. J. Vet. Med. Sci. 2015. 77(4): 387–393.

 

  1. Mantani Y, Nishida M, Yuasa H, Kyoji Yamamoto, Takahara E, Omotehara T, Udayanga KGS, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. Ultrastructural and Histochemical Study on the Paneth Cells in the Rat Ascending Colon. The Anatomical record. 2014. 297(8): 1462–1471.

 

  1. Mantani Y, Yuasa H, Nishida M, Takahara E, Omotehara T, Udayamga KGS, Kawano J, Yokoyama T, Hoshi N, Kitagawa H. Peculiar Composition of Epithelial Cells in Follicle-Associated Intestinal Crypts of Peyer’s Patches in the Rat Small Intestine. J. Vet. Med. Sci. 2014. 76(6): 833–838.