History in Boron Agent R&D Through Industry-Academia-Government Collaboration
R&D for boron agents through industry-academia-government collaboration
| 1990 | Launched R&D for boron compounds that could be useful as pharmaceuticals and agrochemicals |
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| 1993 | Published a paper on a new synthesis method for L-BPA, the active ingredient of Bolofalan (10B), a BNCT boron agent for head and neck cancer |
| 1999 | Established the Osaka Bay Area BNCT Consortium, a boron agent co-creation and research organization |
| 2000-2004 | "Development of nanodevices optimized for cancer neutron capture therapy" selected for Consortium R&D Projects for Regional Revitalization by the Ministry of Economy, Trade and Industry |
| 2005-2007 | "Creation of 10B-boron nanocluster compounds optimized for cancer-boron neutron capture therapy" selected for Practical Application Research by the Japan Science and Technology Agency (JST); research hub established in the Innovation Plaza Osaka in Izum City (later closed down) |
| 2008-2010 | "Research on the advancement of cancer neutron capture therapy based on accelerator neutron sources" selected for Nuclear Fundamental Research Initiative (collaborative research with Kyoto University) by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) |
| 2008-2020 | "Boron agent for boron neutron capture therapy" selected for Development of Creative Technology Seeds by Japan Science and Technology Agency (JST) |
| 2012-2013 | "Establishment of the world's first innovation hub through industry-academia-government collaboration for the demonstration and evaluation of boron agents for BNCT" selected for Innovation Center Establishment Assistance Program Subsidy for Advanced Technology Demonstration and Evaluation Facility Development by the Ministry of Economy, Trade and Industry |
| 2013 | Osaka Prefecture University Nakamozu Campus and other locations receive additional designation as "Kansai Innovation International Strategic Comprehensive Special Zones" |
| 2013-2014 | "Development of synthesis equipment for 18FBPA, a PET probe essential for boron neutron capture therapy (BNCT) and cancer diagnosis" selected for Problem-solving Business Model and Comprehensive Special Zone Coordination Fund by the Ministry of Economy, Trade and Industry. |
| April 1, 2014 | Osaka Prefecture University Research Center for Boron Neutron Capture Therapy (Nakamozu Campus, Building C23) opens |
| 2016-2019 | "Development of an efficient novel synthetic method for 18FBPA and biological evaluation of its cancer specificity in accumulation as an innovative PET probe" selected for Project for Cancer Research and Therapeutic Evolution (P-CREATE) by the Japan Agency for Medical Research and Development (AMED) |
| 2016-2020 | "Research on the creation of tailored cancer-targeting drugs in boron neutron capture therapy (BNCT)" selected for KAKENHI, Grant-in-Aid for Scientific Research (A) by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) |
| 2019-2023 | "Research and development of 18FBPA-PET diagnostic technology for application to boron neutron capture therapy (BNCT)" selected for Practical Research for Innovative Cancer Control by the Japan Agency for Medical Research and Development (AMED) |
| June 1, 2020 | National Health Insurance reimbursement for BNCT treatment with Borofalan (10B) for head and neck cancers begins |
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