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The first positronium imaging of the human brain with the J-PET scanner

Professor Dr. Pawel Moskal （Professor of Institute of Physics, Jagiellonian University, Cracow, Poland）

日時：令和7年5月30日（金）14:30より

場所：中百舌鳥キャンパス A13棟 3階 323室

 Jagiellonian-PET (J-PET) is a novel, cost-effective positron emission tomography technology based on plastic scintillators [1,2]. The J-PET system constructed at the Jagiellonian University is the first multi-photon PET scanner [3] capable of measuring momentum vectors and the orientation of polarization planes of photons originating from positronium decays [4]. Positronium imaging is a newly invented method for imaging the properties of positronium in living organisms [5,6,7,8]. Quantum Entanglement Imaging is a method enabling the imaging the degree of the entanglement of annihilation photons [9].
 We will present the first-ever images of the properties of positronium in humans [8], the first multi-photon images from the decays of positronium atoms into three photons [3], and the first observation of non-maximal entanglement of photons from positronium annihilation in matter [9]. We will discuss the status of the development of (i) positronium imaging and (ii) degree of quantum entanglement imaging as possible diagnostic biomarkers of tissue pathology [10] and biomarkers of hypoxia [11]. We will also discuss the possibility of developing a method for studies of material properties by the measurement of the degree of quantum entanglement of annihilation photons.
References
[1] P. Moskal, E. Ł. Stępień, PET Clinics 15, 439 (2020), [2] P. Moskal et al., Phys. Med. Biol. 66, 175015 (2021), [3] P. Moskal et al., Nature Communication 12, 5658 (2021), [4] P. Moskal et al., Nature Communication 15, 79 (2024), [5] P. Moskal, Positronium Imaging, IEEE NSS MIC 2018, 10.1109/NSSMIC.2018.8824622, [6] P. Moskal, E. Ł. Stępień et al., Nature Reviews Physics 1, 527 (2019), [7] P. Moskal et al., Science Advances 7, eabh4394 (2021), [8] P. Moskal, et al., Science Advances 10, eadp2890 (2024), [9] P. Moskal et al., Science Advances 11, eads3046 (2025), [10] P. Moskal, et al. EJNMMI Phys. 10, 22 (2023), [11] P. Moskal, E. Ł. Stepień, Bio-Algorithms and Med-Systems 17, 311 (2021).

（世話人・連絡先：中瀬生彦、藤原大佑、道上雅孝）

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