業績/Publications
2025年
●Effect of short-term dietary intervention on fecal serotonin, gut microbiome-derived tryptophanase, and energy absorption in a randomized crossover trial: an exploratory analysis. Eiichi Yoshimura, Yuka Hamada, Yoichi Hatamoto, Takashi Nakagata, Hinako Nanri, Yui Nakayama, Chiharu Iwasaka, Takanori Hayashi, Ippei Suzuki, Takafumi Ando, Kazuko Ishikawa-Takata, Shigeho Tanaka, Rei Ono, Michihiro Araki, Hitoshi Kawashima, Yi-An Chen, Jonguk Park, Koji Hosomi, Kenji Mizuguchi, Jun Kunisawa, Motohiko Miyachi. Gut microbes 17(1) 2514137, 2025
●NIBN Japan Microbiome Database, a database for exploring the correlations between human microbiome and health. Yi-An Chen, Hitoshi Kawashima, Jonguk Park, Attayeb Mohsen, Koji Hosomi, Takashi Nakagata, Haruka Murakami, Hinako Nanri, Motohiko Miyachi, Jun Kunisawa, Kenji Mizuguchi. Scientific reports 15(1) 19640-19640, 2025
●Establishment of enterotype-specific antibodies for various diagnostic systems. Ken Yoshii, Eri Node, Mari Furuta, Yoko Tojima, Ayu Matsunaga, Jun Adachi, Narimi Takaai, Makiko Morita, Koji Hosomi, Jun Kunisawa. Scientific reports 15(1) 16814-16814, 2025
●Microbial dysbiosis fuels STING-driven autoinflammation through cyclic dinucleotides. Takayuki Shibahara, Burcu Temizoz, Shiori Egashira, Koji Hosomi, Jonguk Park, Naz Surucu, Albin Björk, Erdal Sag, Takehiko Doi, Rabia Miray Kisla Ekinci, Sibel Balci, Marjan A Versnel, Jun Kunisawa, Masahiro Yamamoto, Tomoya Hayashi, Shuichi Ito, Yuji Kamiyama, Kouji Kobiyama, Peter D Katsikis, Cevayir Coban, Mayda Gursel, Seza Ozen, Sumiyuki Nishida, Atsushi Kumanogoh, Ken J Ishii. Journal of autoimmunity 154 103434, 2025
●Effects of Malted Rice Amazake Consumption on Nutritional Status and Gut Microbiome in Older Patients and Residents of an Integrated Facility for Medical and Long-Term Care. Miki Doi, Rikako Inoue, Koji Hosomi, Jonguk Park, Hitomi Yumioka, A. Yasmin Syauki, Suzumi Kageyama, Haruka Sakaue, Kozo Tanabe, Kenji Mizuguchi, Jun Kunisawa, Yasuyuki Irie. Journal of Nutrition in Gerontology and Geriatrics 44(1) 1-23, 2025
2024年
●Clinical Phenotypes Associated with the Gut Microbiome in Older Japanese People with Care Needs in a Nursing Home. Rikako Inoue, Koji Hosomi, Jonguk Park, Haruka Sakaue, Hitomi Yumioka, Hiroko Kamitani, Yoshiharu Kinugasa, Kaori Harano, A. Yasmin Syauki, Miki Doi, Suzumi Kageyama, Kazuhiro Yamamoto, Kenji Mizuguchi, Jun Kunisawa, Yasuyuki Irie. Nutrients 16(22) 3839. 2024
●High barley intake in non-obese individuals is associated with high natto consumption and abundance of butyrate-producing bacteria in the gut: a cross-sectional study. Satoko Maruyama, Tsubasa Matsuoka, Koji Hosomi, Jonguk Park, Haruka Murakami, Motohiko Miyachi, Hitoshi Kawashima, Kenji Mizuguchi, Toshiki Kobayashi, Tadao Ooka, Zentaro Yamagata, Jun Kunisawa. Frontiers in nutrition 11 1434150, 2024
●Association Between Gut Microbiome Composition and Physical Characteristics in Patients with Severe Motor and Intellectual Disabilities: Perspectives from Microbial Diversity. Suzumi Kageyama, Rikako Inoue, Koji Hosomi, Jonguk Park, Hitomi Yumioka, Miki Doi, Miyuu Miyake, Yuka Nagashio, Yoshiko Shibuya, Nobue Oka, Hirofumi Akazawa, Susumu Kanzaki, Kenji Mizuguchi, Jun Kunisawa, Yasuyuki Irie. Nutrients 16(20) 3546, 2024
●Gut microbiota signatures of vulnerability to food addiction in mice and humans. Solveiga Samulėnaitė, Alejandra García-Blanco, Jordi Mayneris-Perxachs, Laura Domingo-Rodríguez, Judit Cabana-Domínguez, Noèlia Fernàndez-Castillo, Edurne Gago-García, Laura Pineda-Cirera, Aurelijus Burokas, Jose Espinosa-Carrasco, Silvia Arboleya, Jessica Latorre, Catherine Stanton, Koji Hosomi, Jun Kunisawa, Bru Cormand, Jose Manuel Fernández-Real, Rafael Maldonado, Elena Martín-García. Gut 73(11) 1799-1815, 2024
●Group X phospholipase A2 links colonic lipid homeostasis to systemic metabolism via host-microbiota interaction. Hiroyasu Sato, Yoshitaka Taketomi, Remi Murase, Jonguk Park, Koji Hosomi, Takayuki Jujo Sanada, Kenji Mizuguchi, Makoto Arita, Jun Kunisawa, Makoto Murakami. Cell reports 43(10) 114752-114752, 2024
●QcrC is a potential target for antibody therapy and vaccination to control Campylobacter jejuni infection by suppressing its energy metabolism. Koji Hosomi, Noritoshi Hatanaka, Atsushi Hinenoya, Jun Adachi, Yoko Tojima, Mari Furuta, Keita Uchiyama, Makiko Morita, Takahiro Nagatake, Azusa Saika, Soichiro Kawai, Ken Yoshii, Saki Kondo, Shinji Yamasaki, Jun Kunisawa. Frontiers in microbiology 15 1415893, 2024
●Effect of resistance training and chicken meat on muscle strength and mass and the gut microbiome of older women: A randomized controlled trial. Masataka Uchida, Jonguk Park, Shumpei Fujie, Koji Hosomi, Naoki Horii, Kohei Watanabe, Kiyoshi Sanada, Yasushi Shinohara, Kenji Mizuguchi, Jun Kunisawa, Motoyuki Iemitsu, Motohiko Miyachi. Physiological reports 12(12) e16100, 2024
●The omega-3 postbiotic trans-10-cis-15-octadecadienoic acid attenuates contact hypersensitivity in mice through downregulation of vascular endothelial growth factor A. Azusa Saika, Takahiro Nagatake, Shigenobu Kishino, Nahoko Kitamura, Tetsuya Honda, Koji Hosomi, Prabha Tiwari, Eri Node, Soichiro Kawai, Saki Kondo, Kei Ishida, Kenji Kabashima, Jun Ogawa, Jun Kunisawa. Frontiers in cellular and infection microbiology 14 1355679, 2024
●An Exploratory Study on Seasonal Variation in the Gut Microbiota of Athletes: Insights from Japanese Handball Players. Kazuya Toda, Shin Yoshimoto, Keisuke Yoshida, Eri Mitsuyama, Noriyuki Iwabuchi, Koji Hosomi, Takayuki Jujo Sanada, Miyuki Tanaka, Hinako Nanri, Jun Kunisawa, Toshitaka Odamaki, Motohiko Miyachi. Microorganisms 12(4) 781, 2024
●Chemical synthesis of Acetobacter pasteurianus lipid A with a unique tetrasaccharide backbone and evaluation of its immunological functions. Haruki Yamaura, Atsushi Shimoyama, Koji Hosomi, Kazuya Kabayama, Jun Kunisawa, Koichi Fukase. Angewandte chemie (international ed. in English) 63(24) e202402922, 2024
2023年
●Nsp14 of SARS-CoV-2 inhibits mRNA processing and nuclear export by targeting the nuclear cap-binding complex. Jun Katahira, Tatsuya Ohmae, Mayo Yasugi, Ryosuke Sasaki, Yumi Itoh, Tomoko Kohda, Miki Hieda, Masami Yokota Hirai, Toru Okamoto, Yoichi Miyamoto. Nucleic acids research 51(14):7602-7618, 2023
●Association of skeletal muscle function, quantity, and quality with gut microbiota in Japanese adults: A cross-sectional study. Chiharu Iwasaka, Hinako Nanri, Takashi Nakagata, Harumi Ohno, Kumpei Tanisawa, Kana Konishi, Haruka Murakami, Koji Hosomi, Jonguk Park, Yosuke Yamada, Rei Ono, Kenji Mizuguchi, Jun Kunisawa, Motohiko Miyachi. Geriatrics and gerontology international 24(1) 53-60, 2023
●Alcaligenes lipid A functions as a superior mucosal adjuvant to monophosphoryl lipid A via the recruitment and activation of CD11b+ dendritic cells in nasal tissue. Xiao Sun, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Azusa Saika, Haruki Yamaura, Takahiro Nagatake, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa. International immunology 36(1):33-43, 2023
●Effects of energy loads on energy and nutrient absorption rates and gut microbiome in humans: A randomized crossover trial. Eiichi Yoshimura, Yuka Hamada, Yoichi Hatamoto, Takashi Nakagata, Hinako Nanri, Yui Nakayama, Takanori Hayashi, Ippei Suzuki, Takafumi Ando, Kazuko Ishikawa‐Takata, Shigeho Tanaka, Rei Ono, Jonguk Park, Koji Hosomi, Kenji Mizuguchi, Jun Kunisawa, Motohiko Miyachi. Obesity 32(2) 262-272, 2023
●Changes in Fecal Gut Microbiome of Home Healthcare Patients with Disabilities through Consumption of Malted Rice Amazake. Suzumi Kageyama, Rikako Inoue, Jonguk Park, Koji Hosomi, Hitomi Yumioka, Tomo Suka, Kazuaki Teramoto, A. Yasmin Syauki, Miki Doi, Haruka Sakaue, Miyuu Miyake, Kenji Mizuguchi, Jun Kunisawa, Yasuyuki Irie. Physiological genomics 55(12) 647-653, 2023
●Lentinula Edodes Mycelia extract regulates the function of antigen-presenting cells to activate immune cells and prevent tumor-induced deterioration of immune function. Shota Kajiyama, Takahiro Nagatake, Satoru Ishikawa, Koji Hosomi, Yuki Shimada, Yasunori Matsui, Jun Kunisawa. BMC complementary medicine and therapies 23(1) 281, 2023
●Ramen Consumption and Gut Microbiota Diversity in Japanese Women: Cross-Sectional Data from the NEXIS Cohort Study. Jonguk Park, Hiroto Bushita, Ayatake Nakano, Ai Hara, Hiroshi M. Ueno, Naoki Ozato, Koji Hosomi, Hitoshi Kawashima, Yi-An Chen, Attayeb Mohsen, Harumi Ohno, Kana Konishi, Kumpei Tanisawa, Hinako Nanri, Haruka Murakami, Motohiko Miyachi, Jun Kunisawa, Kenji Mizuguchi, Michihiro Araki. Microorganisms 11(8) 1892, 2023
●Gut microbiota alternation with training periodization and physical fitness in Japanese elite athletes. Nobuhiko Akazawa, Mariko Nakamura, Nobuhiko Eda, Haruka Murakami, Takashi Nakagata, Hinako Nanri, Jonguk Park, Koji Hosomi, Kenji Mizuguchi, Jun Kunisawa, Motohiko Miyachi, Masako Hoshikawa. Frontiers in sports and active living 5 1219345, 2023
●Partially hydrolyzed guar gum suppresses the progression of pulmonary arterial hypertension in a SU5416/hypoxia rat model. Takayuki J Sanada, Koji Hosomi, Jonguk Park, Akira Naito, Seiichiro Sakao, Nobuhiro Tanabe, Jun Kunisawa, Koichiro Tatsumi, Takuji Suzuki. Pulmonary circulation 13(3) e12266, 2023
●Characteristic Gut Bacteria in High Barley Consuming Japanese Individuals without Hypertension. Satoko Maruyama, Tsubasa Matsuoka, Koji Hosomi, Jonguk Park, Mao Nishimura, Haruka Murakami, Kana Konishi, Motohiko Miyachi, Hitoshi Kawashima, Kenji Mizuguchi, Toshiki Kobayashi, Tadao Ooka, Zentaro Yamagata, Jun Kunisawa. Microorganisms 11(5) 1246, 2023
●Induction of unique macrophage subset by simultaneous stimulation with LPS and IL-4. Kei Ishida, Takahiro Nagatake, Azusa Saika, Soichiro Kawai, Eri Node, Koji Hosomi, Jun Kunisawa. Frontiers in immunology 14 1111729, 2023
●TLR4 agonist activity of Alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells. Xiao Sun, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Huangwenxian Lan, Yunru Wang, Haruki Yamaura, Takahiro Nagatake, Ken J. Ishii, Shizuo Akira, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa. International immunopharmacology 117 109852, 2023
●Endotoxin-Free Stx2B-C-CPE Vaccine and Its Optimized Adjuvant Regimen for Preventing Food Poisoning. Koji Hosomi, Atsushi Shimoyama, Atsushi Hinenoya, Noritoshi Hatanaka, Takafumi Noguchi, Hirotaka Ebina, Yoko Tojima, Mari Furuta, Masuo Kondoh, Hiroshi Kiyono, Shinji Yamasaki, Koichi Fukase, Jun Kunisawa. Frontiers in bioscience-landmark 28(1) 15, 2023
●Mead acid inhibits retinol-induced irritant contact dermatitis via peroxisome proliferator-activated receptor alpha. Azusa Saika, Prabha Tiwari, Takahiro Nagatake, Eri Node, Koji Hosomi, Tetsuya Honda, Kenji Kabashima, Jun Kunisawa. Frontiers in molecular biosciences 10 1097955, 2023
2022年
●A Pilot Study of A2NTX, a Novel Low-Molecular-Weight Neurotoxin Derived from Subtype A2 for Post-Stroke Lower Limb Spasticity: Comparison with Onabotulinumtoxin A. Ryuji Kaji, Ai Miyashiro, Nori Sato, Taiki Furumoto, Toshiaki Takeuchi, Ryosuke Miyamoto, Tomoko Kohda, Yuishin Izumi, Shunji Kozaki. Toxins 14(11) 739, 2022
●Anti-allergic property of dietary phytoestrogen secoisolariciresinol diglucoside through microbial and β-glucuronidase-mediated metabolism. Kento Sawane, Takahiro Nagatake, Koji Hosomi, Jun Kunisawa. The journal of nutritional biochemistry 112 109219, 2022
●Identification of Human Gut Microbiome Associated with Enterolignan Production. Kento Sawane, Koji Hosomi, Jonguk Park, Kouta Ookoshi, Hinako Nanri, Takashi Nakagata, Yi-An Chen, Attayeb Mohsen, Hitoshi Kawashima, Kenji Mizuguchi, Motohiko Miyachi, Jun Kunisawa. Microorganisms 10(11) 2169, 2022
●Utilization of gut environment-mediated control system of host immunity in the development of vaccine adjuvants. Zilai Liu, Koji Hosomi, Jun Kunisawa. Vaccine 40(36) 5399-5403, 2022
●Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota. Koji Hosomi, Mayu Saito, Jonguk Park, Haruka Murakami, Naoko Shibata, Masahiro Ando, Takahiro Nagatake, Kana Konishi, Harumi Ohno, Kumpei Tanisawa, Attayeb Mohsen, Yi-An Chen, Hitoshi Kawashima, Yayoi Natsume-Kitatani, Yoshimasa Oka, Hidenori Shimizu, Mari Furuta, Yoko Tojima, Kento Sawane, Azusa Saika, Saki Kondo, Yasunori Yonejima, Haruko Takeyama, Akira Matsutani, Kenji Mizuguchi, Motohiko Miyachi, Jun Kunisawa. Nature communications 13(1) 4477, 2022
●Dietary Vitamin B1 Intake Influences Gut Microbial Community and the Consequent Production of Short-Chain Fatty Acids. Jonguk Park, Koji Hosomi (co-first author), Hitoshi Kawashima, Yi-An Chen, Attayeb Mohsen, Harumi Ohno, Kana Konishi, Kumpei Tanisawa, Masako Kifushi, Masato Kogawa, Haruko Takeyama, Haruka Murakami, Tetsuya Kubota, Motohiko Miyachi, Jun Kunisawa, Kenji Mizuguchi. Nutrients 14(10) 2078, 2022
●Altered gut microbiota and its association with inflammation in patients with chronic thromboembolic pulmonary hypertension: a single-center observational study in Japan. Yumiko Ikubo, Takayuki Jujo Sanada, Koji Hosomi, Jonguk Park, Akira Naito, Hiroki Shoji, Tomoko Misawa, Rika Suda, Ayumi Sekine, Toshihiko Sugiura, Ayako Shigeta, Hinako Nanri, Seiichiro Sakao, Nobuhiro Tanabe, Kenji Mizuguchi, Jun Kunisawa, Takuji Suzuki, Koichiro Tatsumi. BMC pulmonary medicine 22(1) 138, 2022
●Relationships between barley consumption and gut microbiome characteristics in a healthy Japanese population: a cross-sectional study. Tsubasa Matsuoka, Koji Hosomi (co-first author), Jonguk Park (co-first author), Yuka Goto, Mao Nishimura, Satoko Maruyama, Haruka Murakami, Kana Konishi, Motohiko Miyachi, Hitoshi Kawashima, Kenji Mizuguchi, Toshiki Kobayashi, Hiroshi Yokomichi, Jun Kunisawa, Zentaro Yamagata. BMC nutrition 8(1) 23, 2022
●Characterization and Demonstration of Mock Communities as Control Reagents for Accurate Human Microbiome Community Measurements. Dieter M Tourlousse, Koji Narita, Takamasa Miura, Akiko Ohashi, Masami Matsuda, Yoshifumi Ohyama, Mamiko Shimamura, Masataka Furukawa, Ken Kasahara, Keishi Kameyama, Sakae Saito, Maki Goto, Ritsuko Shimizu, Riko Mishima, Jiro Nakayama, Koji Hosomi, Jun Kunisawa, Jun Terauchi, Yuji Sekiguchi, Hiroko Kawasaki. Microbiology spectrum 10(2) e0191521, 2022
●Intestinal microbe-dependent ω3 lipid metabolite αKetoA prevents inflammatory diseases in mice and cynomolgus macaques. Takahiro Nagatake, Shigenobu Kishino, Emiko Urano, Haruka Murakami, Nahoko Kitamura, Kana Konishi, Harumi Ohno, Prabha Tiwari, Sakiko Morimoto, Eri Node, Jun Adachi, Yuichi Abe, Junko Isoyama, Kento Sawane, Tetsuya Honda, Asuka Inoue, Akiharu Uwamizu, Takashi Matsuzaka, Yoichi Miyamoto, So-Ichiro Hirata, Azusa Saika, Yuki Shibata, Koji Hosomi, Ayu Matsunaga, Hitoshi Shimano, Makoto Arita, Junken Aoki, Masahiro Oka, Akira Matsutani, Takeshi Tomonaga, Kenji Kabashima, Motohiko Miyachi, Yasuhiro Yasutomi, Jun Ogawa, Jun Kunisawa. Mucosal immunology 15(2) 289-300, 2022
●Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota. Yoshimi Miki, Yoshitaka Taketomi, Yuh Kidoguchi, Kei Yamamoto, Kazuaki Muramatsu, Yasumasa Nishito, Jonguk Park, Koji Hosomi, Kenji Mizuguchi, Jun Kunisawa, Tomoyoshi Soga, Eric Boilard, Siddabasave Gowda B Gowda, Kazutaka Ikeda, Makoto Arita, Makoto Murakami. JCI insight 7(2) e152611, 2022
●Classification of the Occurrence of Dyslipidemia Based on Gut Bacteria Related to Barley Intake. Satoko Maruyama, Tsubasa Matsuoka, Koji Hosomi, Jonguk Park, Mao Nishimura, Haruka Murakami, Kana Konishi, Motohiko Miyachi, Hitoshi Kawashima, Kenji Mizuguchi, Toshiki Kobayashi, Tadao Ooka, Zentaro Yamagata, Jun Kunisawa. Frontiers in nutrition 9 812469, 2022
2021年
●Clinical safety and tolerability of A2NTX, a novel low-molecular-weight neurotoxin derived from botulinum neurotoxin subtype A2 in comparison with subtype A1 toxins. Toshiaki Takeuchi, Tsuyoshi Okuno, Ai Miyashiro, Tomoko Kohda, Ryosuke Miyamoto, Yuishin Izumi, Shunji Kozaki, Ryuji Kaji.Toxins 13(11) 824, 2021
●The cytotoxicity and molecular mechanisms of the Clostridium perfringens NetB toxin. Akm Azharul Islam, Mitsuki Nakatani, Takayuki Nakajima, Tomoko Kohda, Masafumi Mukamoto. The journal of veterinary medical science 83(2) 187-194, 2021
●Effects of Malted Rice Amazake on Constipation Symptoms and Gut Microbiota in Children and Adults with Severe Motor and Intellectual Disabilities: A Pilot Study. Suzumi Kageyama, Rikako Inoue, Koji Hosomi, Jonguk Park, Hitomi Yumioka, Tomo Suka, Yoshihiro Kurohashi, Kazuaki Teramoto, A Yasmin Syauki, Miki Doi, Haruka Sakaue, Kenji Mizuguchi, Jun Kunisawa, Yasuyuki Irie. Nutrients 13(12) 4466, 2021
●Association of Escherichia coli containing polyketide synthase in the gut microbiota with colorectal neoplasia in Japan. Motoki Iwasaki, Rieko Kanehara, Taiki Yamaji, Ryoko Katagiri, Michihiro Mutoh, Yuta Tsunematsu, Michio Sato, Kenji Watanabe, Koji Hosomi, Yasuo Kakugawa, Hiroaki Ikematsu, Kinichi Hotta, Jun Kunisawa, Keiji Wakabayashi, Takahisa Matsuda. Cancer science 113(1) 277-286, 2021
●Mother-to-infant transmission of the carcinogenic colibactin-producing bacteria. Yuta Tsunematsu, Koji Hosomi, Jun Kunisawa, Michio Sato, Noriko Shibuya, Emiko Saito, Haruka Murakami, Yuko Yoshikawa, Yuji Iwashita, Noriyuki Miyoshi, Michihiro Mutoh, Hideki Ishikawa, Haruhiko Sugimura, Motohiko Miyachi, Keiji Wakabayashi, Kenji Watanabe. BMC microbiology 21(1) 235, 2021
●Comprehensive analysis of gut microbiota of a healthy population and covariates affecting microbial variation in two large Japanese cohorts. Jonguk Park, Kumiko Kato, Haruka Murakami, Koji Hosomi, Kumpei Tanisawa, Takashi Nakagata, Harumi Ohno, Kana Konishi, Hitoshi Kawashima, Yi-An Chen, Attayeb Mohsen, Jin-Zhong Xiao, Toshitaka Odamaki, Jun Kunisawa, Kenji Mizuguchi, Motohiko Miyachi. BMC microbiology 21(1) 151, 2021
●12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice. Takahiro Nagatake, Yuki Shibata, Sakiko Morimoto, Eri Node, Kento Sawane, So-Ichiro Hirata, Jun Adachi, Yuichi Abe, Junko Isoyama, Azusa Saika, Koji Hosomi, Takeshi Tomonaga, Jun Kunisawa. Scientific reports 11(1) 10426, 2021
●The Gut Microbiome as a Promising Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma. Takehiro Otoshi, Tatsuya Nagano, Jonguk Park, Koji Hosomi, Tomoya Yamashita, Motoko Tachihara, Tokiko Tabata, Reina Sekiya, Yugo Tanaka, Kazuyuki Kobayashi, Kenji Mizuguchi, Tomoo Itoh, Yoshimasa Maniwa, Jun Kunisawa, Yoshihiro Nishimura. Anticancer research 42(3) 1589-1598, 2021
●Lipopolysaccharide from Gut-Associated Lymphoid Tissue-Resident Alcaligenes faecalis: Complete Structure Determination and Chemical Synthesis of its Lipid A. Atsushi Shimoyama, Flaviana Di Lorenzo, Haruki Yamaura, Keisuke Mizote, Angelo Palmigiano, Molly D Pither, Immacolata Speciale, Tomoya Uto, Seiji Masui, Luisa Sturiale, Domenico Garozzo, Koji Hosomi, Naoko Shibata, Kazuya Kabayama, Yukari Fujimoto, Alba Silipo, Jun Kunisawa, Hiroshi Kiyono, Antonio Molinaro, Koichi Fukase. Angewandte chemie (international ed. in English) 60(18) 10023-10031, 2021
●ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α. Azusa Saika, Takahiro Nagatake, So-Ichiro Hirata, Kento Sawane, Jun Adachi, Yuichi Abe, Junko Isoyama, Sakiko Morimoto, Eri Node, Prabha Tiwari, Koji Hosomi, Ayu Matsunaga, Tetsuya Honda, Takeshi Tomonaga, Makoto Arita, Kenji Kabashima, Jun Kunisawa. FASEB journal 35(4) e21354, 2021
●Relationship between Nutrient Intake and Human Gut Microbiota in Monozygotic Twins. Natsuko Matsumoto, Jonguk Park, Rie Tomizawa, Hitoshi Kawashima, Koji Hosomi, Kenji Mizuguchi, Chika Honda, Ritsuko Ozaki, Yoshinori Iwatani, Mikio Watanabe, Jun Kunisawa. Medicina (Kaunas) 57(3) 275, 2021
●Categorization of the Ocular Microbiome in Japanese Stevens-Johnson Syndrome Patients With Severe Ocular Complications. Mayumi Ueta, Koji Hosomi (co-first author), Jonguk Park, Kenji Mizuguchi, Chie Sotozono, Shigeru Kinoshita, Jun Kunisawa. Frontiers in cellular and infection microbiology 11 741654, 2021
●Chemically Synthesized Alcaligenes Lipid A as an Adjuvant to Augment Immune Responses to Haemophilus Influenzae Type B Conjugate Vaccine. Zilai Liu, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Xiao Sun, Huangwenxian Lan, Yunru Wang, Haruki Yamaura, Davie Kenneth, Azusa Saika, Takahiro Nagatake, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa. Frontiers in pharmacology 12 763657, 2021
●Enzymatically synthesized exopolysaccharide of a probiotic strain Leuconostoc mesenteroides NTM048 shows adjuvant activity to promote IgA antibody responses. Chiaki Matsuzaki, Yukari Nakashima, Ikuto Endo, Yusuke Tomabechi, Yasuki Higashimura, Saki Itonori, Koji Hosomi, Jun Kunisawa, Kenji Yamamoto, Keiko Hisa. Gut microbes 13(1) 1949097, 2021
●Lipopolysaccharide Derived From the Lymphoid-Resident Commensal Bacteria Alcaligenes faecalis Functions as an Effective Nasal Adjuvant to Augment IgA Antibody and Th17 Cell Responses. Yunru Wang, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Takahiro Nagatake, Yukari Fujimoto, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa. Frontiers in immunology 12 699349, 2021
2020年
●Translocation domain of botulinum neurotoxin A subtype 2 potently induces entry into neuronal cells. Tomoko Kohda, Kentaro Tsukamoto, Yasushi Torii, Shunji Kozaki, Masafumi Mukamoto. Microbiology and immunology 64(7) 502-511, 2020
●Fully human monoclonal antibodies effectively neutralizing botulinum neurotoxin serotype B. Takuhiro Matsumura, Sho Amatsu, Ryo Misaki, Masahiro Yutani, Anariwa Du, Tomoko Kohda, Kazuhito Fujiyama, Kazuyoshi Ikuta, Yukako Fujinaga. Toxins 12(5) 302, 2020
●Impact of the intestinal environment on the immune responses to vaccination. Koji Hosomi, Jun Kunisawa. Vaccine 38(44) 6959-6965, 2020
●Analysis of a plasmid encoding botulinum neurotoxin type G gene in Clostridium argentinense. Yoshihiko Sakaguchi, Jumpei Uchiyama, Akira Také, Kazuyoshi Gotoh, Masakiyo Sakaguchi, Tomonori Suzuki, Yumiko Yamamoto, Koji Hosomi, Tomoko Kohda, Masafumi Mukamoto, Shunji Kozaki, Shunji Hayashi, Keiji Oguma. Anaerobe 66 102281, 2020
●Vitamin B1 Supports the Differentiation of T Cells through TGF-β Superfamily Production in Thymic Stromal Cells. So-Ichiro Hirata, Kento Sawane, Jun Adachi, Junko Isoyama, Yuki Sugiura, Ayu Matsunaga, Koji Hosomi, Takeshi Tomonaga, Makoto Suematsu, Takahiro Nagatake, Jun Kunisawa. iScience 23(9) 101426, 2020
●Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity. Ken Yoshii, Koji Hosomi, Atsushi Shimoyama, Yunru Wang, Haruki Yamaura, Takahiro Nagatake, Hidehiko Suzuki, Huangwenxian Lan, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa. Microorganisms 8(8) 1102, 2020
●Adjuvant Activity of Synthetic Lipid A of Alcaligenes, a Gut-Associated Lymphoid Tissue-Resident Commensal Bacterium, to Augment Antigen-Specific IgG and Th17 Responses in Systemic Vaccine. Yunru Wang, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Haruki Yamaura, Takahiro Nagatake, Tomomi Nishino, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa. Vaccines 8(3) 395, 2020
●Gut microbial composition in patients with atrial fibrillation: effects of diet and drugs. Tokiko Tabata, Tomoya Yamashita, Koji Hosomi, Jonguk Park, Tomohiro Hayashi, Naofumi Yoshida, Yoshihiro Saito, Koji Fukuzawa, Kana Konishi, Haruka Murakami, Hitoshi Kawashima, Kenji Mizuguchi, Motohiko Miyachi, Jun Kunisawa, Ken-Ichi Hirata. Heart and vessels 36(1) 105-114, 2020
●Gut microbiota modification suppresses the development of pulmonary arterial hypertension in an SU5416/hypoxia rat model. Takayuki J. Sanada, Koji Hosomi, Hiroki Shoji, Jonguk Park, Akira Naito, Yumiko Ikubo, Asako Yanagisawa, Takayuki Kobayashi, Hideki Miwa, Rika Suda, Seiichiro Sakao, Kenji Mizuguchi, Jun Kunisawa, Nobuhiro Tanabe, Koichiro Tatsumi. Pulmonary circulation 10(3) 2045894020929147, 2020
●Diversity of energy metabolism in immune responses regulated by micro-organisms and dietary nutrition. Koji Hosomi, Jun Kunisawa. International immunology 32(7) 447-454, 2020
●Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition. Emiko Sato, Koji Hosomi, Akiyo Sekimoto, Eikan Mishima, Yuji Oe, Daisuke Saigusa, Sadayoshi Ito, Takaaki Abe, Hiroshi Sato, Jun Kunisawa, Toshimitsu Niwa, Nobuyuki Takahashi. Biochemical and biophysical research communications 525(3) 773-779, 2020
●Impaired mucociliary motility enhances antigen-specific nasal IgA immune responses to a cholera toxin-based nasal vaccine. Huangwenxian Lan, Hidehiko Suzuki, Takahiro Nagatake, Koji Hosomi, Koji Ikegami, Mitsutoshi Setou, Jun Kunisawa. International immunology 2(8):559-568, 2020
●Maternal ω3 docosapentaenoic acid inhibits infant allergic dermatitis through TRAIL-expressing plasmacytoid dendritic cells in mice. So-Ichiro Hirata, Takahiro Nagatake, Kento Sawane, Koji Hosomi, Tetsuya Honda, Sachiko Ono, Noriko Shibuya, Emiko Saito, Jun Adachi, Yuichi Abe, Junko Isoyama, Hidehiko Suzuki, Ayu Matsunaga, Takeshi Tomonaga, Hiroshi Kiyono, Kenji Kabashima, Makoto Arita, Jun Kunisawa. Allergy 75(8) 1939-1955, 2020
●MANTA, an integrative database and analysis platform that relates microbiome and phenotypic data. Yi-An Chen, Jonguk Park, Yayoi Natsume-Kitatani, Hitoshi Kawashima, Attayeb Mohsen, Koji Hosomi, Kumpei Tanisawa, Harumi Ohno, Kana Konishi, Haruka Murakami, Motohiko Miyachi, Jun Kunisawa, Kenji Mizuguchi. PloS one 15(12) e0243609, 2020
●Lymphoid Tissue-Resident Alcaligenes Establish an Intracellular Symbiotic Environment by Creating a Unique Energy Shift in Dendritic Cells. Koji Hosomi, Naoko Shibata, Atsushi Shimoyama, Tomoya Uto, Takahiro Nagatake, Yoko Tojima, Tomomi Nishino, Haruko Takeyama, Koichi Fukase, Hiroshi Kiyono, Jun Kunisawa. Frontiers in microbiology 11 561005, 2020
●Fatty acid metabolism in the host and commensal bacteria for the control of intestinal immune responses and diseases. Koji Hosomi, Hiroshi Kiyono, Jun Kunisawa, Gut microbes 11(3):276-284, 2020
●Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia. Ichiro Takahashi, Koji Hosomi, Takahiro Nagatake, Hirokazu Toubou, Daiki Yamamoto, Ikue Hayashi, Yosuke Kurashima, Shintaro Sato, Naoko Shibata, Yoshiyuki Goto, Fumito Maruyama, Ichiro Nakagawa, Asaomi Kuwae, Akio Abe, Jun Kunisawa, Hiroshi Kiyono. Int Immunol 32(2):133-141, 2020
～2019年
●17(S),18(R)‐epoxyeicosatetraenoic acid generated by cytochrome P450 BM‐3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G‐protein‐coupled receptor 40‐mediated neutrophil suppression. Azusa Saika, Takahiro Nagatake, Shigenobu Kishino, Si-Bum Park, Tetsuya Honda, Naomi Matsumoto, Michiko Shimojou, Sakiko Morimoto, Prabha Tiwari, Eri Node, So-Ichiro Hirata, Koji Hosomi, Kenji Kabashima, Jun Ogawa, Jun Kunisawa. FASEB bioadvances 2(1) 59-71, 2019
●Dietary omega-3 fatty acid ameliorates allergic rhinitis via eosinophilic production of the anti-allergic lipid mediator 15-hydroxyeicosapentaenoic acid in mice. Kento Sawane, Takahiro Nagatake, Koji Hosomi, So-Ichiro Hirata, Jun Adachi, Yuichi Abe, Junko Isoyama, Hidehiko Suzuki, Ayu Matsunaga, Satoshi Fukumitsu, Kazuhiko Aida, Takeshi Tomonaga, Makoto Arita, Jun Kunisawa. Nutrients 11(12) 2868, 2019
●Clostridium perfringens enterotoxin-based protein engineering for the vaccine design and delivery system. Huangwenxian Lan, Koji Hosomi, Jun Kunisawa. Vaccine 37(42) 6232-6239, 2019
●BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses. Takahiro Nagatake, So-Ichiro Hirata, Tomoaki Koga, Etsushi Kuroda, Shingo Kobari, Hidehiko Suzuki, Koji Hosomi, Naomi Matsumoto, Yaulia Yanrismet, Michiko Shimojou, Sakiko Morimoto, Fumiyuki Sasaki, Ken J Ishii, Takehiko Yokomizo, Jun Kunisawa. Mucosal immunology 12(5) 1082-1091, 2019
●Analysis of oral microbiota in Japanese oral cancer patients using 16S rRNA sequencing. Yasuharu Takahashi, Jonguk Park, Koji Hosomi, Tomonori Yamada, Ayaka Kobayashi, Yuji Yamaguchi, Susumu Iketani, Jun Kunisawa, Kenji Mizuguchi, Nobuko Maeda, Tomoko Ohshima. Journal of oral biosciences 61(2) 120-128, 2019
●Metabolism of dietary and microbial vitamin B family in the regulation of host immunity. Ken Yoshii, Koji Hosomi, Kento Sawane, Jun Kunisawa. Frontiers in nutrition 6 48, 2019
●Development of a bivalent food poisoning vaccine: augmented antigenicity of the C-terminus of Clostridium perfringens enterotoxin by fusion with the B subunit of Escherichia coli Shiga toxin 2. Koji Hosomi, Atsushi Hinenoya, Hidehiko Suzuki, Takahiro Nagatake, Tomomi Nishino, Yoko Tojima, So-Ichiro Hirata, Ayu Matsunaga, Masuo Kondoh, Shinji Yamasaki, Jun Kunisawa. International immunology 31(2) 91-100, 2019
●Immunological association of inducible bronchus-associated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice. Takahiro Nagatake, Hidehiko Suzuki, So-Ichiro Hirata, Naomi Matsumoto, Yasuko Wada, Sakiko Morimoto, Ayaka Nasu, Michiko Shimojou, Mitsuo Kawano, Kentaro Ogami, Yusuke Tsujimura, Etsushi Kuroda, Norifumi Iijima, Koji Hosomi, Ken J Ishii, Tetsuya Nosaka, Yasuhiro Yasutomi, Jun Kunisawa. International immunology 30(10) 471-481, 2018
●Immunostimulatory effect on dendritic cells of the adjuvant-active exopolysaccharide from Leuconostoc mesenteroides strain NTM048. Chiaki Matsuzaki, Chikahiro Takagaki, Yasuki Higashimura, Yukari Nakashima, Koji Hosomi, Jun Kunisawa, Kenji Yamamoto, Keiko Hisa. Bioscience, biotechnology, and biochemistry 82(9) 1647-1651, 2018
●Lymphoid tissue-resident Alcaligenes LPS induces IgA production without excessive inflammatory responses via weak TLR4 agonist activity. Naoko Shibata, Jun Kunisawa, Koji Hosomi, Yukari Fujimoto, Keisuke Mizote, Naohiro Kitayama, Atsushi Shimoyama, Hitomi Mimuro, Shintaro Sato, Natsuko Kishishita, Ken J Ishii, Koichi Fukase, Hiroshi Kiyono. Mucosal immunology 11(3) 693-702, 2018
●Development of Adjuvant-Free Bivalent Food Poisoning Vaccine by Augmenting the Antigenicity of Clostridium perfringens Enterotoxin. Hidehiko Suzuki, Koji Hosomi, Ayaka Nasu, Masuo Kondoh, Jun Kunisawa. Frontiers in immunology 9 2320, 2018
●Response to "Standardized methods must be used to compare the properties of botulinum toxin serotypes". Tomoko Kohda, Keiji Nakamura, Koji Hosomi, Yasushi Torii, Shunji Kozaki, Masafumi Mukamoto. Microbiology and immunology 61(12) 560, 2017
●Characterization of the functional activity of botulinum neurotoxin subtype B6. Tomoko Kohda, Keiji Nakamura, Koji Hosomi, Yasushi Torii, Shunji Kozaki, Masafumi Mukamoto. Microbiology and immunology 61(11) 482-489, 2017
●Structural characterization of the immunostimulatory exopolysaccharide produced by Leuconostoc mesenteroides strain NTM048. Chiaki Matsuzaki, Chikahiro Takagaki, Yusuke Tomabechi, Lennart S. Forsberg, Christian Heiss, Parastoo Azadi, Kenji Matsumoto, Toshihiko Katoh, Koji Hosomi, Jun Kunisawa, Kenji Yamamoto, Keiko Hisa. Carbohydrate research 448 95-102, 2017
●Method for preparing DNA from feces in guanidine thiocyanate solution affects 16S rRNA-based profiling of human microbiota diversity. Koji Hosomi, Harumi Ohno, Haruka Murakami, Yayoi Natsume-Kitatani, Kumpei Tanisawa, Soichiro Hirata, Hidehiko Suzuki, Takahiro Nagatake, Tomomi Nishino, Kenji Mizuguchi, Motohiko Miyachi, Jun Kunisawa. Scientific reports 7(1) 4339, 2017
●The Specific Roles of Vitamins in the Regulation of Immunosurveillance and Maintenance of Immunologic Homeostasis in the Gut. Koji Hosomi, Jun Kunisawa. Immune network 17(1) 13-19, 2017
●Morphological and genetic characterization of group I Clostridium botulinum type B strain 111 and the transcriptional regulator spoIIID gene knockout mutant in sporulation. Koji Hosomi, Ritsuko Kuwana, Hiromu Takamatsu, Tomoko Kohda, Shunji Kozaki, Masafumi Mukamoto. Anaerobe 33 55-63, 2015
●Genotyping and characterisation of the secretory lipolytic enzymes of Malassezia pachydermatis isolates collected from dogs. Hideshi Teramoto, Yuko Kumeda, Kumio Yokoigawa, Koji Hosomi, Shunji Kozaki, Masafumi Mukamoto, Tomoko Kohda. Veterinary record open 2(2) e000124, 2015
●Complete nucleotide sequence of a plasmid containing the botulinum neurotoxin gene in Clostridium botulinum type B strain 111 isolated from an infant patient in Japan. Koji Hosomi, Yoshihiko Sakaguchi, Tomoko Kohda, Kazuyoshi Gotoh, Daisuke Motooka, Shota Nakamura, Kaoru Umeda, Tetsuya Iida, Shunji Kozaki, Masafumi Mukamoto. molecular genetics and genomics 289(6) 1267-1274, 2014
●Draft genome sequence of Clostridium botulinum type B strain Osaka05, isolated from an infant patient with botulism in Japan. Yoshihiko Sakaguchi, Koji Hosomi, Jumpei Uchiyama, Yoshitoshi Ogura, Kaoru Umeda, Masakiyo Sakaguchi, Tomoko Kohda, Masafumi Mukamoto, Naoaki Misawa, Shigenobu Matsuzaki, Tetsuya Hayashi, Shunji Kozaki. Genome Announcements 2(1) e01010-13, 2014