業績 Publications

原著論文 Original papers

太字は所属教員を示す。

2026年
  • Kirara Inoue, Tsutomu Matsubara, Hayato Urushima, Hideto Yuasa, Atsuko Daikoku, Kazuo Ikeda, Norifumi Kawada, Katsutoshi Yoshizato, Takayuki Suzuki and Misako Sato-Matsubara*. A Hepatocyte Membrane-Based Culture System Recapitulating the Physiological Microenvironment of Hepatic Stellate Cells.  American Journal of Physiology–Cell Physiology, 2026, 330 (2), C434–C447.
  • Hiroko Ikenaga, Ritsuzo Kozuka, Kirara Inoue, Tsutomu Matsubara, Naoshi Odagiri, Kanako Yoshida, Kohei Kotani, Etsushi Kawamura, Atsushi Hagihara, Hideki Fujii, Masaru Enomoto, Sawako Uchida-Kobayashi*. 12-Hydroxyheptadecatrienoic Acid Predicts Hepatocellular Carcinoma Development During Nucleos(t)ide Analogue Therapy. Cancers, 2026, 18(4), 542.
2025年
  • Yutaka Yasui, Misako Sato-Matsubara, Masaru Enomoto, Tsutomu Matsubara, Mana Kosugi, Kirara Inoue, Truong Huu Hoang, Hideto Yuasa, Hideki Fujii, Atsuko Daikoku, Yoshihiro Ikura, Etsushi Kawamura, Sawako Uchida-Kobayashi, Akihiro Tamori, Norifumi Kawada*. Plasma fibulin-5 as a novel marker for advanced fibrosis in chronic hepatitis C. Gastro Hep Advances, 2025, 2(5), 100827.
  • Masako Okada, Misako Sato-Matsubara, Masaru Enomoto, Truong Huu Hoang, Sawako Uchida-Kobayashi, Akihiro Tamori, Tsutomu Matsubara, Kenichi Kohashi, Takeaki Ishizawa, Norifumi Kawada*. Prognostic Significance of Poly (ADP-Ribose) Polymerase 1 Binding Protein Expression and CD8+ Tumor-Infiltrating Lymphocytes in Hepatocellular Carcinoma. Laboratory investigation; a journal of technical methods and pathology, 2025, 105(11) 104226-104226.
  • Atsuko Daikoku, Tsutomu Matsubara, Misako Sato-Matsubara, Miku Ando, Chiho Kadono, Sayuri Takada, Naoshi Odagiri, Hideto Yuasa, Hayato Urushima, Katsutoshi Yoshizato, Norifumi Kawada, Kazuo Ikeda*. Lawsone can suppress liver fibrosis by inhibition of YAP signaling and induction of CYGB expression in hepatic stellate cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2025, 191 118520-118520.
2024年
  • Hanh Vinh Ngo, Thuy Thi Thanh Le, Hieu Ngoc Vu, Hai Hoang, Hiroko Ikenaga, Misako Sato-Matsubara, Sawako Uchida-Kobayashi, Hayato Urushima, Khanh Van Nguyen, Ha Thi Nguyen, Hiroji Shinkawa, Shoji Kubo, Naoko Ohtani, Masaru Enomoto, Akihiro Tamori, Norifumi Kawada*. Poorly Differentiated Hepatocellular Carcinoma Cells Avoid Apoptosis by Interacting with T Cells via CD40-CD40L Linkage. The American journal of pathology,2024, 194(7) 1230-1247.
  • Yo Tanaka, Misako Sato-Matsubara, Daisuke Tsuruta, Hiroshi Tanaka, Chiho Kadono, Koji Sugawara, Norifumi Kawada, Kazumasa Wakamatsu, Shosuke Ito, Katsutoshi Yoshizato*. Cytoglobin functions as a redox regulator of melanogenesis in normal epidermal melanocytes. Pigment Cell & Melanoma Research, 2024, 37(2) 276-285.
2023年
  • Yoshinori Okina, Misako Sato-Matsubara, Yasutoshi Kido, Hayato Urushima, Atsuko Daikoku, Chiho Kadono, Yu Nakagama, Yuko Nitahara, Truong Huu Hoang, Le Thi Thanh Thuy, Tsutomu Matsubara, Naoko Ohtani, Kazuo Ikeda, Katsutoshi Yoshizato, Norifumi Kawada*. Nitric oxide derived from cytoglobin-deficient hepatic stellate cells causes suppression of cytochrome c oxidase activity in hepatocytes. Antioxidants & redox signaling, 2023,38(7-9) 463-479. 
  • Truong Huu Hoang, Misako Sato-Matsubara, Hideto Yuasa, Tsutomu Matsubara, Le Thi Thanh Thuy, Hiroko Ikenaga, Dong Minh Phuong, Ngo Vinh Hanh, Vu Ngoc Hieu, Dinh Viet Hoang, Hoang Hai, Yoshinori Okina, Masaru Enomoto, Akihiro Tamori, Atsuko Daikoku, Hayato Urushima, Kazuo Ikeda, Ninh Quoc Dat, Yutaka Yasui, Hiroji Shinkawa, Shoji Kubo, Ryota Yamagishi, Naoko Ohtani, Katsutoshi Yoshizato, Jordi Gracia-Sancho, Norifumi Kawada*.Cancer cells produce liver metastasis via gap formation in sinusoidal endothelial cells through proinflammatory paracrine mechanisms. Science Advances, 2022, 8(39) eabo5525.
  • 井上喜来々、河田則文*、肝細胞膜による肝星細胞活性化抑制の分子機序、日本門脈圧亢進症学会雑誌、2023年、29(2) 127-133.
2022年
  • Hieu VN, Thuy LTT, Hai H, Dat NQ, Hoang DV, Hanh NV, Phuong DM, Hoang TH, Sawai H, Yoshitsugu S, Sato-Matsubara M, Oikawa D, Tokunaga F, Yoshizato K, Kawada N*. Capacity of extracellular globins to reduce liver fibrosis via scavenging reactive oxygen species and promoting MMP-1 secretion. Redox Biology, 2022, Vol 52,102286.
  • Minh Phuong Dong, Le Thi Thanh Thuy, Dinh Viet Hoang, Hoang Hai, Truong Huu Hoang, Misako Sato-Matsubara, Vu Ngoc Hieu, Atsuko Daikoku, Ngo Vinh Hanh, Hayato Urushima, Ninh Quoc Dat, Sawako Uchida-Kobayashi, Masaru Enomoto, Naoko Ohtani, Akihiro Tamori, Norifumi Kawada*. Soluble immune checkpoint protein CD27 is a novel prognostic biomarker of HCC development in HCV-SVR patients. The American journal of pathology, 2022, 192(10) 1379-1396.
  • Katsutoshi Yoshizato, Toshio Taira, Misako Sato-Matsubara, Shizuko Sekiguchi, Yoriko Yabunaka, Yukimi Kira, Tetsu Ohashi, Atsuko Daikoku, Ken Ofusa, Chiho Kadono, Daisuke Oikawa, Tsutomu Matsubara, Yu Nakagama, Yasutoshi Kido, Fuminori Tokunaga, Kazuo Ikeda, Akira Kaneko, Norifumi Kawada*. Cloaking the ACE2 receptor with salivary cationic proteins inhibits SARS-CoV-2 entry. Journal of biochemistry, 2022, 172(4) 205-216.
  • Dinh Viet Hoang, Le Thi Thanh Thuy, Hoang Hai, Vu Ngoc Hieu, Kenjiro Kimura, Daisuke Oikawa, Yoshihiro Ikura, Ninh Quoc Dat, Truong Huu Hoang, Misako Sato-Matsubara, Minh Phuong Dong, Ngo Vinh Hanh, Sawako Uchida-Kobayashi, Fuminori Tokunaga, Shoji Kubo, Naoko Ohtani, Katsutoshi Yoshizato, Norifumi Kawada*. Cytoglobin attenuates pancreatic cancer growth via scavenging reactive oxygen species. Oncogenesis, 2022, 11(1) 23-23.
2021年
  • Takada S, Matsubara T*, Fujii H, Sato-Matsubara M, Daikoku A, Odagiri N, Amano-Teranishi Y, Kawada N, Ikeda K. Stress can attenuate hepatic lipid accumulation via elevation of hepatic β-muricholic acid levels in mice with nonalcoholic steatohepatitis. Lab Invest, 2021;101(2):193-203.
  • Dat, NQ, Thuy LTT, Hieu VN, Hai H, Hoang DV, Hai NTT, Thuy TTV, Komiya T, Rombouts K, Dong MP, Hanh NV, Hoang TH, Sato-Matsubara M, Daikoku A, Kadono C, Oikawa D, Yoshizato K, Tokunaga F, Pinzani M, Kawada N*. (2021). Hexa Histidine-Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species. Hepatology, 73(6): 2527-2545.
  • Odagiri N, Matsubara T, Sato-Matsubara M, Fujii H, Enomoto M, Kawada N*. Anti-fibrotic treatments for chronic liver diseases: The present and the future. Clin Mol Hepatol, 2021;27(3):413-424.
2020年
  • 松原三佐子、吉里則文、河田則文*、抗線維化薬開発の最新情報、総説、日本消化器病学会誌　2020 117(1) 52-63. 
  • Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K, Thanh Thuy LT, Ichikawa H, Minamiyama Y, Kadota M, Fujii H, Enomoto M, Ikeda K, Yoshizato K, Pinzani M, Kawada N*. TGF-β1-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. J Hepatol, 2020;73(4):882-895. (共同筆頭著者)　
2019年
  • 松原三佐子、吉里則文、河田則文*、肝星細胞活性化と肝硬変・肝がん、細胞、肝星細胞の活性化の仕組み、サイトグロビンの作用から見えてくる新しい視点、2019 51(11) 530-534.
  • Kozuka R, Enomoto M, Sato-Matsubara M, Yoshida K, Motoyama H, Hagihara A, Fujii H, Uchida-Kobayashi S, Morikawa H, Tamori A, Kawada N, Murakami Y*. Association between HLA-DQA1/DRB1 polymorphism and development of hepatocellular carcinoma during entecavir treatment. J Gastroenterol Hepatol, 2019 May;34(5):937-946.　
2018年
  • Thi Thanh Hai N, Thuy LTT, Shiota A, Kadono C, Daikoku A, Hoang DV, Dat NQ, Sato-Matsubara M, Yoshizato K, Kawada N*. Selective overexpression of cytoglobin in stellate cells attenuates thioacetamide-induced liver fibrosis in mice. Sci Rep, 2018 Dec 14;8(1):17860.
  • 松原三佐子、河田則文*、肝硬変、肝線維化、肝疾患における新薬開発の動向　消化器疾患の最新医療、先端医療シリーズ 2018, 49, 214-219.
2017年
  • Sato-Matsubara M, Matsubara T, Daikoku A, Okina Y, Longato L, Rombouts K, Thuy LTT, Adachi J, Tomonaga T, Ikeda K, Yoshizato K, Pinzani M, Kawada N*. Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling. J Biol Chem, 2017;292(46):18961-18972.
  • Matsuura K, Sawai H, Ikeo K, Ogawa S, Iio E, Isogawa M, Shimada N, Komori A, Sato-Matsubara M, *Tanaka Y.「他25名」Genome-wide association study identifies TLL1 variant associated with development of hepatocellular carcinoma after eradication of hepatitis C virus infection. Gastroenterology, 2017,52:1383-1394.
  • 松原三佐子、河田則文*、サイトグロビンと肝疾患　医学のあゆみ：TOPICS, 2017, 261, 829-830