PUBLICATION

2024

1. Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells and alleviates hyperglycemia in mice
Tanaka C, Harada N, Teraoka Y, Urushizaki H, Shinmori Y, Onishi T, Yotsumoto Y, Ito Y, Kitakaze T, Inui T, Murata Y, Inui H, and Yamaji R.
[Sci. Rep., 14, 3244, 2024
]

2. 全トランス型レチノイン酸に依存したLGR6の筋分化における一過性発現は筋芽細胞の分化と融合を調節する

北風智也、辰巳理奈、山口真由、中辻あいの、原田直樹、山地亮一.
[ビタミン, 98, 70-73, 2024] リンク先


3.母乳に含まれる脂肪酸アミドと認知機能
窪田 舞、北風 智也、原田 直樹、山地 亮一.
[ビタミン, in press]

2023

1. All-trans retinoic acid-responsive LGR6 is transiently expressed during myogenic differentiation and is required for myoblast differentiation and fusion
Kitakaze T, Tatsumi R, Yamaguchi M, Nakatsuji A, Harada N,  and Yamaji R.
[Int. J. Mol. Sci., 24, 9035, 2023]

2. Aged garlic extract prevents alcohol-induced cytotoxicity through induction of aldehyde dehydrogenase 2 in the liver of mice
Kitakaze T, Inoue M,  and Ashida H.
[Mol. Nutr. Food Res., e2200627, 2023]

3. Mung bean peptides promote glucose uptake via Jak2 activation in L6 myotubes
Yoshioka Y, Zhang Q, Wang X, Kitakaze T, Yamashita Y, Kohno M, and Ashida H.
[Food Funct., 14, 5375-5390, 2023]

4. Single oral administration of quercetin glycosides prevented acute hyperglycemia by promoting GLUT4 translocation in skeletal muscles through the activation of AMPK in mice
Yamashita Y, Jiang H, Okada F, Kitakaze T, Yoshioka Y, and Ashida H.
[J. Clin. Biochem. Nutr., 74, 37-46, 2024]

5. 卵巣老化のメカニズムと食品成分による予防
田中千智、北風智也、原田直樹、山地亮一.
[ビタミン, 97, 79-83, 2023
]

6. インクレチンの生理作用と機能性食品成分による調節・模倣
原田直樹.
[日本栄養・食糧学会誌., 76, 141-147, 2023]


7. 網膜に集まるカロテノイド
北風智也.
[生物工学会誌, 101, 552, 2023]

8.フラボノイドの概日リズム調節作用
北風智也.
[Food style 21., 27, 73-77, 2023]

2022

1. Androgen receptor suppresses β-adrenoceptor-mediated CREB activation and thermogenesis in brown adipose tissue of male mice
Harada N, Kubo K, Onishi T, Kitakaze T, Goto T, Inui H, and Yamaji R.
[J. Biol. Chem., 298, 102619, 2022
]

2. Identification of G-protein coupled receptor 55 (GPR55) as a target of curcumin
Harada N, Okuyama M, Teraoka Y, Arahori Y, Shinmori Y, Horiuchi H, Luis P.B, Joseph A.I, Kitakaze T, Matsumura S, Hira T, Yamamoto N, Inui T, Goshima N, Schneider C, Inui H, and Yamaji R.
[npj Sci. Food, 6, 4, 2022]

3. Transport form and pathway from intestine to peripheral tissues and intestinal absorption and metabolism properties of oleamide
Kobayashi Y, Watanabe N, Hiura R, Kubota M, Furuta K, Sugimoto K, Murota K, Nakamura E, Matsuura T, Kai K, Inui T, Kitakaze T, Harada N, and Yamaji R.
[J. Agric. Food Chem., 70, 15499–15508, 2022]

4. Curcumin activates G protein-coupled receptor 97 (GPR97) in a manner different from glucocorticoid
Harada N, Arahori Y, Okuyama M, Luis P.B, Joseph A.I, Kitakaze T, Goshima N, Schneider C, Inui H, and Yamaji R.
[Biochem. Biophys. Res. Commun., 595, 41-46, 2022]

5. Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1α in mouse soleus muscles
Kitakaze T, Sugihira T, Kameyama H, Maruchi A, Kobayashi Y, Harada N, and Yamaji R.
[J. Clin. Biochem. Nutr., 71, 112-131, 2022]

6. Dietary oleamide attenuates obesity induced by housing mice in small cages
Kobayashi Y, Kubota M, Sugimoto K, Kitakaze T, Harada N, Yamaji R.
[Biosci. Biotechnol. Biochem., 86, 1095-1105, 2022]

7. Functions of nutrient-sensing nuclear receptors in health
Yamaji R.
[J. Nutr. Sci. Vitaminol., 68, S14-S16, 2022]


8. Preventive effects of black soybean polyphenols on non-alcoholic fatty liver disease in three different mouse models
Yamamoto M, Yoshioka Y, Kitakaze T, Yamashita Y, Ashida H.
[Food Funct., 13, 1000-1014, 2022]

9. Pectolinarigenin induces antioxidant enzymes through Nrf2/ARE pathway in HepG2 cells
Shiraiwa M, Kitakaze T, Yamashita Y, Ukawa Y, Mukai K, Ashida H.
[Antioxidants, 11, 675, 2022]


10. Age-dependent sex difference of non-alcoholic fatty liver disease in TSOD and db/db mice
Dungubat E, Kusano H, Mori I, Tawara H, Sutoh M, Ohkura N, Takanashi M, Kuroda M, Harada N, Udo E, Souda M, Furusato B, Fukusato T, Takahashi Y.
[PLos One, 17, e0278580, 2022]

11. 骨格筋における異所性脂肪蓄積に対するレチノイン酸受容体アゴニストの抑制効果
辰巳理奈、北風智也、原田直樹、山地亮一.
[ビタミン, 96, 239-243, 2022]

12. LOH症候群における代謝異常のメカニズム:膵β細胞と腸内細菌の関与
原田直樹.
[Bio Clinica, 37, 89-91, 2022]

13. 食品因子の薬物代謝系を介した生体防御機能に関する研究
北風智也.
[日本栄養・食糧学会誌, 75, 291-296, 2022]

2021

1. Oleamide rescues tibialis anterior muscle atrophy of mice housed in small cages
Kobayashi Y, Watanabe N, Kitakaze T, Izawa T, Sugimoto K, Kai K, Harada N, and Yamaji R.
[Br. J. Nutr., 126, 481-491, 2021]

2. Exopolysaccharides from a Scandinavian fermented milk viili increase butyric acid and Muribaculum members in the mouse gut
Yamane T, Handa S, Imai M, Harada N, Sakamoto T, Ishida T, Nakagaki T, Nakano Y.
[Food Chem. Mol. Sci., 3, 100042, 2021]

3. Gタンパク質共役エストロゲン受容体の活性化による抗肥満効果
佐々木里那、原田直樹、山地亮一.
[ビタミン, 95, 20-23, 2021]

4. クルクミンの生理作用解析ツールとしての代謝産物および構造類似体
荒堀有美、原田直樹、山地亮一.
[ビタミン,  95, 286-289, 2021]

5. ビタミン・バイオファクター総合辞典 「3.1 カロテノイド(項目責任者:山地亮一)」
「3.1.1 はじめに(概論):山地亮一」
「3.1.6 トピックス(カロテンと骨格筋と脂肪組織):北風智也・山地亮一」
[朝倉書店, 日本ビタミン学会編集, 2021]

6. 膵β細胞の発達へ及ぼすアンドロゲンの作用
原田直樹.
[Precision Medicine, 4, 73-75, 2021]  

2020

1. Role of gut microbiota in sex- and diet-dependent metabolic disorders that lead to early mortality of androgen receptor-deficient male mice
Harada N, Hanada K, Minami Y, Kitakaze T, Ogata Y, Tokumoto H, Sato T, Kato S, Inui H, and Yamaji R.
[Am. J. Physiol. Endocrinol. Metab., 318, E525-E537, 2020]

2. Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56
Kitakaze T, Yoshikawa M, Kobayashi Y, Kimura N, Goshima N, Ishikawa T, Ogata Y, Yamashita Y, Ashida H, Harada N, and Yamaji R.
[Biochim. Biophys. Acta - Mol. Cell Res., 1867, 118563, 2020]

3. β-Cryptoxanthin improves p62 accumulation and muscle atrophy in the soleus muscle of senescence-accelerated mouse-prone 1 mice
Noguchi M, Kitakaze T, Kobayashi Y, Mukai K, Harada N, and Yamaji R.
[Nutrients, 12, 2180, 2020]

4. Food texture affects glucose tolerance by altering pancreatic β-cell function in mice consuming high-fructose corn syrup
Harada N, Nomura M, Yoda Y, Matsumura S, Inui H, and Yamaji R.
[PLoS One, 15, e0233797, 2020]

5. Relationship between gut environment, feces-to-food ratio, and androgen deficiency-induced metabolic disorders
Harada N, Minami Y, Hanada K, Hanaoka R, Kobayashi Y, Izawa T, Sato T, Kato S, Inui H, and Yamaji R.
[Gut Microbes, 12, 1817719, 2020]

6. Biological activity of pseudovitamin B12 on cobalamin-dependent methylmalonyl-CoA mutase and methionine synthase in mammalian cultured COS-7 cells
Bito T, Bito M, Hirooka T, Okamoto N, Harada N, Yamaji R, Nakano Y, Inui H, and Watanabe F.
[Molecules, 25, 3268, 2020]

7. Effects of crystalline and amorphous forms of paramylon from Euglena gracilis on the development of water-immersion restraint stress-induced gastric ulcer
Ogushi M, Imai M, Yoshizawa M, Suzuki K, and Harada N.
[Food Sci. Technol. Res., 26, 153-158, 2020]

8. Aronia juice supplementation inhibits lipid accumulation in both normal and obesity model mice
Yamane T, Imai M, Handa S, Harada N, Yamaji R, Sakamoto T, Ishida T, Inui H, Nakagaki T, Nakano Y.
[PharmaNutrition, 14, 100223, 2020]

9. Effects of caffeine and chlorogenic acid on nonalcoholic steatohepatitis in mice induced by choline-deficient, L-amino acid-defined, high-fat diet
Dungubat E, Watabe S, Togashi-Kumagai A, Watanabe M, Kobayashi Y, Harada N, Yamaji R, Fukusato T, Lodon G, Sevjid B, Takahashi Y.
[Nutrients, 12, 3886, 2020]

10. Effects of low ethanol consumption on nonalcoholic steatohepatitis in mice
Takahashi Y, Watabe S, Togashi-Kumagai A, Watanabe M, Dungubat E, Kusano H, Kobayashi Y, Harada N, Yamaji R, Sugimoto K, and Fukusato T.
[Alcohol, 87, 51-61, 2020]

11. Inhibitory effects of eucalyptus and banaba leaf extracts on nonalcoholic steatohepatitis induced by a high-fructose/high-glucose diet in rats
Takahashi Y, Sugimoto K, Soejima Y, Kumagai A, Koeda T, Shojo A, Nakagawa K, Harada N, Yamaji R, Inui H, Yamanouchi T, and Fukusato T.
[Prime Archives in Biomedical Sciences, 2020]

12. アピゲニンによる骨格筋量の調節機構
前川大輔、原田直樹、山地亮一.
[ビタミン, 94, 406-409, 2020]

13. α-カロテン、β-カロテン、β-クリプトキサンチンなどのプロビタミンA:カロテノイドの健康機能に関して、最近の動向
山地亮一.
[日本食品安全協会会誌, 15(2), 71-77, 2020]

14. 膵β細胞量調節の性差と食の影響
原田直樹.
[Medical Science Digest, 46, 37-38, 2020]

15. インスリン分泌を介した男性ホルモンの血糖調節作用と高脂肪食摂取のインパクト
原田直樹.
[アグリバイオ, 4, 66-68, 2020]

16. 膵β細胞への男性ホルモンの作用
原田直樹.
[Bio Clinica, 35, 79-81, 2020]  

2019

1. Fetal androgen signaling defects affect pancreatic β-cell mass and function, leading to glucose intolerance in high-fat diet-fed male rats
Harada N, Yotsumoto Y, Katsuki T, Yoda Y, Masuda T, Nomura M, Shiraki N, Inui H, and Yamaji R.
[Am. J. Physiol. Endocrinol. Metab., 317, E731-E741, 2019]

2. 5-Hydroxy-7-methoxyflavone derivatives from Kaempferia parviflora induce skeletal muscle hypertrophy
Ono S, Yoshida N, Maekawa D, Kitakaze T, Kobayashi Y, Kitano T, Fujita T, Okuwa-Hayashi H, Harada N, Nakano Y, and Yamaji R.
[Food Sci. Nutr., 7, 312-321, 2019]

3. Tomatidine, a steroidal alkaloid from green tomatoes, reduces palmitate-induced lipid accumulation by activating AMPK via vitamin D receptor-mediated signaling in human HepG2 hepatocytes
Kusu H, Yoshida H, Kudo M, Okuyama M, Harada N, Tsuji-Naito K, and Akagawa M.
[Mol. Nutr. Food Res., 63, e1801377, 2019]

4. 摂食量調節と代謝ホメオスタシス制御における脂肪酸アミドの生理機能
小林恭之、原田直樹、山地亮一.
[ビタミン, 93, 66-69, 2019]

5. 筋分化におけるレチノイドX受容体の重要性
山口真由、原田直樹、山地亮一.
[ビタミン, 93, 253-256, 2019]

6. 骨格筋の健康におけるメトキシフラボンの有用性
山地亮一.
[ビタミン, 93, 299-302, 2019]

7. 抗肥満効果をもつirisinのビタミンAによる発現制御
吉川実樹、原田直樹、山地亮一.
[ビタミン, 93, 444-447, 2019]

8. ホルモンによる膵島機能制御
稲垣暢也、出崎克也、原田直樹、原田範雄.
[Islet Equality, 8, 5-14, 2019]  

2018

1. Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions
Harada N, Yoda Y, Yotsumoto Y, Masuda T, Takahashi Y, Katsuki T, Kai K, Shiraki N, Inui H, and Yamaji R.
[Am. J. Physiol. Endocrinol. Metab., 314, E274-E286, 2018]

2. Stereoselective effects of lactate enantiomers on the enhancement of 3T3-L1 adipocyte differentiation
Harada N, Hirano I, Inui H, Yamaji R.
[Biochem. Biophys. Res. Commun., 498, 105-110, 2018]

3. Lactoferrin promotes murine C2C12 myoblast proliferation and differentiation, and myotube hypertrophy
Kitakaze T, Oshimo M, Kobayashi Y, Ryu M, Suzuki YA, Inui H, Harada N, and Yamaji R.
[Mol. Med. Rep., 17, 5912-5920, 2018]

4. Role of androgens in energy metabolism affecting on body composition, metabolic syndrome, type 2 diabetes, cardiovascular disease, and longevity: Lessons from a meta-analysis and rodent studies
Harada N.
[Biosci. Biotechnol. Biochem., 82, 1667-1682, 2018]

5. Theophylline suppresses interleukin-6 expression by inhibiting glucocorticoid receptor signaling in pre-adipocytes
Mitani T, Takaya T, Harada N, Katayama S, Yamaji R, Nakamura S, and Ashida H.
[Arch. Biochem. Biophys., 646, 98-106, 2018]

6. Heat stress prevents the decrease in succinate dehydrogenase activity in the extensor digitorum longus of streptozotocin-induced diabetic rats
Nonaka K, Une S, Komatsu R, Yamaji R, and Akiyama J.
[Physiol. Res., 67, 117-126, 2018]

7. ラット小腸粘膜および組換えマウス型のβ-カロテン15,15'-モノオキシゲナーゼ活性に及ぼすリノール酸の影響
北川雅啓、山地亮一、原田直樹、中野長久、細谷圭助.
[ビタミン, 92, 416-423, 2018]

8. 性ホルモンが操る腸内細菌叢が代謝疾患を制御する~腸内細菌叢を標的としたアンドロゲンの作用~
原田直樹、山地亮一.
[化学と生物, 56, 2-4, 2018]

9. 代謝センシングー健康,食,美容,薬,そして脳の代謝を知るー「第11章 カロテンとその代謝物による骨格筋のヘルスベネフィット」
北風智也、原田直樹、山地亮一.
[シーエムシー出版, 97-104, 2018(監修:三林浩二)]  

2017

1. S-Equol activates cAMP signaling at the plasma membrane of INS-1 pancreatic β-cells and protects against streptozotocin-induced hyperglycemia by increasing β-cell function in male mice
Horiuchi H, Usami A, Shirai R, Harada N, Ikushiro S, Sakaki T, Nakano Y, Inui H, and Yamaji R.
[J. Nutr., 147, 1631-1639, 2017]

2. Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor β and increases skeletal muscle mass in young female mice
Ogawa M, Kitano T, Kawata N, Sugihira T, Kitakaze T, Harada N, and Yamaji R.
[J. Nutr. Biochem., 49, 63-70, 2017]

3. Lactoferrin induces tropoelastin expression by activating the lipoprotein receptor-related protein 1-mediated phosphatidylinositol 3-kinase/Akt pathway in human dermal fibroblasts
Ryu M, Nogami A, Kitakaze T, Harada N, Suzuki YA, and Yamaji R.
[Cell Biol. Int., 41, 1325-1334, 2017]

4. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) aggregation causes mitochondrial dysfunction during oxidative stress-induced cell death
Nakajima H, Itakura M, Kubo T, Kaneshige A, Harada N, Izawa T,  Azuma YT, Kuwamura M, Yamaji R, and Takeuchi T.
[J. Biol. Chem., 292, 4727-4742, 2017]

5. コラーゲンペプチドの骨格筋における有用性
北風智也、原田直樹、山地亮一.
[ビタミン, 91, 433-436, 2017]

6. ステロイド生合成経路におけるβ-carotene 15,15′-oxygenase 1の関与
日野李保、北風智也、原田直樹、山地亮一.
[ビタミン, 91, 702-705, 2017]

7. 膵β細胞制御による糖代謝調節に関する食品機能学的研究
原田直樹.
[日本栄養・食糧学会誌, 70, 225-230, 2017]

8. 非栄養素の分子栄養学「第10章 骨格筋量とエストロゲン受容体βアゴニスト:大豆イソフラボンの可能性」
山地亮一.
[建帛社, 155-169, 2017]

2016

1. Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice
Harada N, Hanaoka R, Horiuchi H, Kitakaze T, Mitani T, Inui H, and Yamaji R.
[Sci. Rep., 6, 23001, 2016]

2. pVHL-mediated degradation of HIF-2α regulates estrogen receptor α expression in normoxic breast cancer cells
Higashimura Y, Kitakaze T, Harada N, Inui H, Nakano Y, and Yamaji R.
[FEBS Lett., 590, 2690-2699, 2016]

3. The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy
Kitakaze T, Sakamoto T, Kitano T, Inoue N, Sugiura F, Harada N, and Yamaji R.
[Biochem. Biophys. Res. Commun., 478, 1292-1297, 2016]

4. Mogrol derived from Siraitia grosvenorii mogrosides suppresses 3T3-L1 adipocyte differentiation by reducing cAMP-response element-binding protein phosphorylation and increasing AMP-activated protein kinase phosphorylation
Harada N, Ishihara M, Horiuchi H, Ito Y, Tabata H, Suzuki YA, Nakano Y, Yamaji R, and Inui H.
[PLoS One, 11, e0162252, 2016]

5. Hypogonadism alters cecal and fecal microbiota in male mice
Harada N, Hanaoka R, Hanada K, Izawa T, Inui H, and Yamaji R.
[Gut Microbes, 7, 533-539, 2016]  

2015

1. Autophagic degradation of the androgen receptor mediated by increased phosphorylation of p62 suppresses apoptosis in hypoxia
Mitani T, Minami M, Harada N, Ashida H, and Yamaji R.
[Cell. Signal., 27, 1994-2001, 2015]

2. Androgen receptor silences thioredoxin-interacting protein and competitively inhibits glucocorticoid receptor-mediated apoptosis in pancreatic β-cells
Harada N, Katsuki T, Takahashi Y, Masuda T, Yoshinaga M, Adachi T, Izawa T, Kuwamura M, Nakano Y, Yamaji R, and Inui H.
[J. Cell. Biochem., 116, 998-1006, 2015]

3. Female-specific regulation of skeletal muscle mass by USP19 in young mice
Ogawa M, Kitakaze T, Harada N, and Yamaji R.
[J. Endocrinol., 225, 135-145, 2015]

4. β-Carotene increases muscle mass and hypertrophy in the soleus muscle in mice
Kitakaze T, Harada N, Imagita H, and Yamaji R.
[J. Nutr. Sci. Vitaminol., 61, 481-487, 2015]

5. Protein arginine methyltransferase 10 is required for androgen-dependent proliferation of LNCaP prostate cancer cells
Harada N, Takagi T, Nakano Y, Yamaji R, and Inui H.
[Biosci. Biotechnol. Biochem., 79, 1430-1437, 2015]

6. Competitive and compensatory effects of androgen signaling and glucocorticoid signaling
Harada N, Inui H, and Yamaji R.
[Receptors Clin. Investig., 2, e785, 2015]

7. Inhibitory effects of Eucalyptus and Banaba leaf extracts on nonalcoholic steatohepatitis induced by a high-fructose/high-glucose diet in rats
Takahashi Y, Sugimoto K, Soejima Y, Kumagai A, Koeda T, Shojo A, Nakagawa K, Harada N, Yamaji R, Inui H, Yamanouchi T, and Fukusato T.
[Biomed. Res. Int., 2015, 296207, 2015]

8. Glyceraldehyde-3-phosphate dehydrogenase aggregates accelerate amyloid-β amyloidogenesis in Alzheimer disease
Itakura M, Nakajima H, Kubo T, Semi Y, Kume S, Higashida S, Kaneshige A, Kuwamura M, Harada N, Kita A, Azuma YT, Yamaji R, Inui T, and Takeuchi T.
[J. Biol. Chem., 290, 26072-26087, 2015]

9. Construction of sensitive reporter assay yeasts for comprehensive detection of ligand activities of human corticosteroid receptors through inactivation of CWP and PDR genes
Ito-Harashima S, Shiizaki K, Kawanishi M, Kakiuchi K, Onishi K, Yamaji R, and Yagi T.
[J. Pharmacol. Toxicol. Methods, 74, 41-52, 2015]

10. 多機能性を持つMoonlighting Proteins
原田直樹、三谷塁一、山地亮一.
[生化学, 87, 279-285, 2015]

11. 膵β細胞のインスリン分泌能におよぼすポリフェノール類の作用
堀内寛子、原田直樹、山地亮一.
[ビタミン, 89, 341-347, 2015]

12. カロテノイドによる加齢性筋萎縮の予防・改善作用
北風智也、原田直樹、山地亮一.
[ビタミン, 89, 543-545, 2015]

2014

1. Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells
Mitani T, Ito Y, Harada N, Nakano Y, Inui H, Ashida H, and Yamaji R.
[J. Nutr. Sci. Vitaminol., 60, 122-128, 2014]

2. Resveratrol inhibits hypoxia-inducible factor-1α-mediated androgen receptor signaling and represses tumor progression in castration-resistant prostate cancer
Mitani T, Harada N, Tanimori S, Nakano Y, Inui H, and Yamaji R.
[J. Nutr. Sci. Vitaminol., 60, 276-282, 2014]

3. S-Equol enantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells
Horiuchi H, Harada N, Adachi T, Nakano Y, Inui H, and Yamaji R.
[J. Nutr. Sci. Vitaminol., 60, 291-296, 2014]

4. Dodecylamine derivative of hydroxocobalamin acts as a potent inhibitor of cobalamin-dependent methionine synthase in mammalian cultured COS-7 cells
Bito T, Yasui M, Iwaki T, Yabuta Y, Ichiyanagi T, Yamaji R, Nakano Y, Inui H, and Watanabe F.
[Food Nutr. Sci., 5, 1311-1318, 2014]

5. 女性の疾患と美容のための機能性素材の開発「第1章 骨格筋と女性ホルモン/大豆イソフラボン」
小川真弘、原田直樹、山地亮一.
[シーエムシー出版, 1-13, 2014(監修:山地亮一)]

6. 膵β細胞の機能を改善するビタミンDとビオチンの抗2型糖尿病作用
堀内寛子、原田直樹、山地亮一.
[ビタミン, 88, 530-534, 2014]  

2013

1. The preventive effect of β-carotene on denervation-induced soleus muscle atrophy in mice
Ogawa M, Kariya Y, Kitakaze T, Yamaji R, Harada N, Sakamoto T, Hosotani K, Nakano Y, and Inui H.
[Br. J. Nutr., 109, 1349-1358, 2013]

2. Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4´-amino-3,5-dihydroxy-trans-stilbene
Ito Y, Mitani T, Harada N, Isayama A, Tanimori S, Takenaka S, Nakano Y, Inui H, and Yamaji R.
[J. Nutr. Sci. Vitaminol., 59, 358-64, 2013]

3. Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxygenase-1 expression
Higashimura Y, Naito Y, Takagi T, Mizushima K, Hirai Y, Harusato A, Ohnogi, H, Yamaji R, Inui H, Nakano Y, and Yoshikawa T.
[J. Gastroenterol., 48, 897-909, 2013]

4. Biochemical characterization of a GH53 endo-β-1,4-galactanase and GH35 exo-β-1,4-galactanase from Penicillium chrysogenum
Sakamoto T, Nishimura Y, Makino Y, Sunagawa Y, and Harada N.
[Appl. Microbiol. Biotechnol., 97, 2895-2906, 2013]

5. エストロゲン受容体βアゴニストとしてのS-エクオールの女性疾患に対する有効性に関する最近の知見
小川真弘、原田直樹、山地亮一.
[ビタミン, 87, 450-453, 2013]

6. β-Carotene 15,15'-monooxygenase1(BCMO1)の新しい生理的機能
北風智也、原田直樹、山地亮一.
[ビタミン, 87, 696-699, 2013]

7. カロテノイドによる筋萎縮抑制
山地亮一.
[バイオインダストリー, 10, 36-43, 2013]  

2012

1. Coordinated action of hypoxia-inducible factor-1α and β-catenin in androgen receptor signaling
Mitani T, Harada N, Nakano Y, Inui H, and Yamaji R.
[J. Biol. Chem., 287, 33594-33606, 2012]

2. Androgen deprivation causes truncation of the C-terminal region of androgen receptor in human prostate cancer LNCaP cells
Harada N, Inoue K, Yamaji R, Nakano Y, and Inui H.
[Cancer Sci., 103, 1022-1027, 2012]

3. Glyceraldehyde-3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability
Ikeda I, Yamaji R, Irie K, Kioka N, and Murakami A.
[Arch. Biochem. Biophys., 528, 141-147, 2012]

4. レスベラトロールによるアンドロゲン受容体の転写活性阻害機構について
原田直樹、山地亮一、中野長久、乾博.
[ビタミン, 86, 21-23, 2012]

5. 乳がん細胞におけるグリセルアルデヒド-3-リン酸デヒドロゲナーゼの低酸素応答機構の解析
東村泰希、山地亮一、原田直樹、中野長久、乾博.
[ビタミン, 86, 84-86, 2012]

6. 抗酸化物質としてのレスベラトロールの多機能性
三谷塁一、原田直樹、山地亮一.
[ビタミン, 86, 687-689, 2012]  

2011

1. 17β-Estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor α
Ogawa M, Yamaji R, Higashimura Y, Harada N, Ashida H, Nakano Y, and Inui H.
[J. Biol. Chem., 286, 41455-41465, 2011]

2. Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment
Mitani T, Yamaji R, Higashimura Y, Harada N, Nakano Y, and Inui H.
[J. Steroid Biochem. Mol. Biol., 123, 58-64, 2011]

3. Inhibitory mechanisms of the transcriptional activity of androgen receptor by resveratrol: Implication of DNA binding and acetylation of the receptor
Harada N, Atarashi K, Murata Y, Yamaji R, Nakano Y, and Inui H.
[J. Steroid Biochem. Mol. Biol., 123, 65-70, 2011]

4. Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells
Higashimura Y, Nakajima Y, Yamaji R, Harada N, Shibasaki F, Nakano Y, and Inui H.
[Arch. Biochem. Biophys., 509, 1-8, 2011]

5. Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms
Higashimura Y, Terai T, Yamaji R, Mitani T, Ogawa M, Harada N, Inui H, and Nakano Y.
[Biochem. Biophys. Res. Commun., 413, 201-205, 2011]

6. Suppression of inducible nitric oxide synthase expression and amelioration of lipopolysaccharide-induced liver injury by polyphenolic compounds in Eucalyptus globulus leaf extract
Sugimoto K, Sakamoto S, Nakagawa K, Hayashi S, Harada N, Yamaji R, Nakano Y, and Inui H.
[Food Chem., 125, 442-446, 2011]

7. (-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD box RNA helicase p68
Tanaka T, Ishii T, Mizuno D, Mori T, Yamaji R, Nakamura Y, Kumazawa S, Nakayama T, and Akagawa M.
[Free Radic. Biol. Med., 50, 1324-1335, 2011]

8. Purification, characterization and gene cloning of two forms of a thermostable endo-xylanase from Streptomyces sp. SWU10
Deesukon W, Nishimura Y, Harada N, Sakamoto T, and Sukhumsirichart W.
[Process Biochem., 46, 2255-2262, 2011]

2010

1. Involvement of three glutamine tracts in human androgen receptor transactivation
Harada N, Mitani T, Higashimura Y, Yamaji R, Okamoto K, Nakano Y, and Inui H.
[J. Steroid Biochem. Mol. Biol., 118, 77-84, 2010]

2. Construction of a dominant negative form of human hypoxia-inducible factor-2α
Higashimura Y, Yamaji R, Harada N, Nakao M, Nakano Y, and Inui H.
[Biosci. Biotech. Biochem., 74, 2100-2102, 2010]

3. A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2- and COOH-terminal interaction of androgen receptor
Ogawa M, Yamaji R, Mitani T, Murata Y, Nakao M, Harada N, Nakano Y, and Inui H.
[Biosci. Biotechnol. Biochem., 74, 1965-1968, 2010]

4. Eucalyptus leaf extract suppresses the postprandial elevation of portal, cardiac and peripheral fructose concentrations after sucrose ingestion in rats
Sugimoto K, Hosotani T, Kawasaki T, Nakagawa K, Hayashi S, Nakano Y, Inui H, and Yamanouchi T.
[J. Clin. Biochem. Nutr., 46, 205-211, 2010]

5. Digestion and absorption of Siraitia grosvenori triterpenoids in the rat
Murata Y, Ogawa T, Suzuki YA, Yoshikawa S, Inui H, Sugiura M, and Nakano Y.
[Biosci. Biotechnol. Biochem., 74, 673-676, 2010]

6. Methyladeninylcobamide functions as the cofactor of methionine synthase in a Cyanobacterium, Spirulina platensis NIES-39
Tanioka Y, Miyamoto E, Yabuta Y, Ohnishi K, Fujita T, Yamaji R, Misono H, Shigeoka S, Nakano Y, Inui H, and Watanabe F.
[FEBS Lett., 584, 3223-3226, 2010]

7. Sensitive and convenient yeast reporter assay for high-throughput analysis by using a secretory luciferase from Cypridina noctiluca
Tochigi Y, Sato N, Sahara T, Wu C, Saito S, Irie T. Fujibuchi W, Goda T, Yamaji R, Ogawa M, Ohmiya Y, and Ohgiya S.
[Anal. Chem., 82, 5768-5776, 2010]

8. Potential use of Bschofia javanica as an active ingredient of functional foods and cosmeceutical products possessing hyaluronidase, collagenase, tyrosinase and urease inhibitory effects
Barla F, Horinishi A, Harada N, Yamaji R, Enomoto T, Suzuki N, Maenaka H, Nakano Y, and Inui H.
[Jpn. J. Compl. Alternative Med., 7, 129-133, 2010]

2009

1. Cobalamin deficiency results in an abnormal increase in L-methylmalonyl-CoA mutase expression in rat liver and COS-7 cells
Nakao M, Hironaka S, Harada N, Adachi T, Bito T, Yabuta Y, Watanabe F, Miura T, Yamaji R, Inui H, and Nakano Y.
[Brit. J. Nutr., 101, 492-498, 2009]

2. Inhibitive effects of alkyl gallates on hyaluronidase and collagenase
Barla F, Higashijima H, Funai S, Sugimoto K, Harada N, Yamaji R, Fujita T, Nakano Y, and Inui H.
[Biosci. Biotechnol. Biochem., 73, 2335-2337, 2009]

3. Occurrence of pseudovitamin B12 and its possible function as the cofactor of cobalamin-dependent methionine synthase in a cyanobacterium Synechocystis sp. PCC680
Tanioka Y, Yabuta Y, Yamaji R, Shigeoka S, Nakano Y, Watanabe F, and Inui H.
[J. Nutr. Sci. Vitaminol., 55, 518-521, 2009]

4. Rats fed fructose-enriched diets have characteristics of nonalcoholic hepatic steatosis
Kawasaki T, Igarashi K, Koeda T, Sugimoto K, Nakagawa K, Hayashi S, Yamaji R, Inui H, Fukusato T, and Yamanouchi T.
[J. Nutr., 139, 2067-2071, 2009]

5. Hydrolyzable tannins as antioxidants in the leaf extract of Eucalyptus globulus possessing tyrosinase and hyaluronidase inhibitory activities
Sugimoto K, Nakagawa K, Hayashi S, Amakura Y, Yoshimura M, Yoshida T, Yamaji R, Nakano Y, and Inui H.
[Food Sci. Technol. Res., 15, 331-336, 2009]

6. 小麦ふすま可溶化物のラット水浸拘束ストレスによる胃潰瘍抑制効果
庄條愛子, 吉澤みな子, 三枝尚洋, B. Florin, 原田直樹, 山地亮一, 乾 博, 村田修一, 船川弘万, 中野長久
[ビタミン, 83, 538-541, 2009]

2008

1. RanBP10 acts as a novel coactivator for the androgen receptor
Harada N, Yokoyama T, Yamaji R, Nakano Y, and Inui H.
[Biochem. Biophys. Res. Commun., 368, 121-125, 2008]

2. ARA24/Ran enhances the androgen-dependent NH2- and COOH-terminal interaction of the androgen receptor
Harada N, Ohmori Y, Yamaji R, Higashimura Y, Okamoto K, Isohashi F, Nakano Y, and Inui H.
[Biochem. Biophys. Res. Commun., 373, 373-377, 2008]

3. Vitamin B12 deficiency results in abnormal regulation of serine dehydratase and tyrosine aminotransferase activities correlatad with impairment of the adenylyl cyclase system in rat liver
Ebara S, Nakao M, Tomoda M, Yamaji R, Watanabe F, Inui H, and Nakano Y.
[Brit. J. Nutr., 99, 503-510, 2008]

4. Analysis of vitamin B12 in food by silica gel 60 TLC and bioautography with vitamin B12-dependent Escherichia coli 215
Tanioka Y, Yabuta Y, Miyamoto E, Inui H, and Watanabe F.
[J. Liq. Chromatogr. Relat. Technol., 31, 1977-1985, 2008]

5. Covalent modification of proteins by green tea polyphenol (-)-epigallocatechin-3-gallate through autoxidation
Ishii T, Mori T, Tanaka T, Mizuno D, Yamaji R, Kumazuwa S, Nakayama T, and Akagawa M.
[Free Radic. Biol. Med., 45, 1384-1394, 2008]

6. Moonlightingタンパク質として見直されるGAPDHの機能~アンドロゲン受容体の転写活性におけるコアクチベーターとしての役割~
原田直樹、山地亮一、 乾博.
[化学と生物, 46, 817-819, 2008] 

2007

1. Glyceraldehyde-3-phosphate dehydrogenase enhances transcriptional activity of androgen receptor in prostate cancer cells
Harada N, Yasunaga R, Higashimura Y, Yamaji R, Fujimoto K, Moss J, Inui H, and Nakano Y.
[J. Biol. Chem., 282, 22651-22661, 2007]

2. Resveratol down-regulates the androgen receptor at the post-translational level in prostate cancer cells
Harada N, Murata Y, Yamaji R, Miura T, Inui H, and Nakano Y.
[J. Nutr. Sci. Vitaminol., 53, 556-560, 2007]

3. Antidiabetic effect of long-term supplementation with Siratia grosvenorion the spontaneously diabetic Goto-Kakizaki rat
Suzuki YA, Tomoda M, Murata Y, Inui H, Sugiura M, and Nakano Y.
[Brit. J. Nutr., 97, 770-775, 2007]

2006

1. Abnormal increase in the expression level of proliferation cell nuclear antigen (PCNA) in the liver and hepatic injury in rats with dietary cobalamin deficiency
Nakao M. Kono N. Adachi S. Ebara S. Adachi T. Miura. T. Yamaji R. Inui H, and Nakano Y.
[J. Nutr. Sci. Vitaminol., 52, 168-173, 2006]

2. Purification and characterization of a corrinoid-compound in an edible cyanobacterium Aphanizomenon flos-aquae as a nutritional supplementary food
Miyamoto E, Tanioka Y, Nakao M, Barla F, Inui H, Fujita T, Watanabe F, and Nakano Y.
[J. Agric. Food Chem., 54, 9604-9607, 2006]

3. Recent advances in molecular pharmacology of the histamine systems: organic cation transporters as a histamine transporter and histamine metabolism
Ogasawara M, Yamauchi K, Satoh YI, Yamaji R, Inui K, Jonker JW, Schinkel AH, and Maeyama K.
[J. Pharmacol. Sci., 101, 24-30, 2006]

4. Separation and properties of two novel NADP+-dependent alcohol dehydrogenases from Euglena gracilis Z
Munir I, Swati ZA, Rashid MH, Yamaji R, Inui H, and Nakano Y.
[Pak. J. Biol. Sci., 6, 2743-2747, 2006]

5. Subcellular localization of glyoxylate cycle key enzymes involved in oxalate biosynthesis of wood-destroying basidiomycete Fomitopsis palustris grown on glucose
Sakai S, Nishide T, Munir E, Baba K, Inui H, Nakano Y, Hattori T, and Shimada M.
[Microbiology, 152, 1857-1866, 2006]

6. Sweetness characteristics of the triterpene glycosides in Siraitia grosvenori
Murata Y, Yoshikawa S., Suzuki YA, Sugiura M, Inui H, and Nakano Y.
[Nippon Shokuhin Kagaku Kogaku Kaishi, 53, 527-533, 2006] 

2005

1. Glyceraldehyde-3-phosphate dehydrogenase in the extracellular space inhibits cell spreading
Yamaji R, Chatani E, Harada N, Sugimoto K, Inui H, and Nakano Y.
[Biochim. Biophys. Acta - Gen. Subjects, 1726, 261-271, 2005]

2. Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats
Sugimoto K, Suzuki J, Nakagawa K, Hayashi S, Enomoto T, Fujita T, Yamaji R, Inui H, and Nakano Y.
[Brit. J. Nutr., 93, 957-963, 2005]

3. Triterpene glycosides of Siraitia grosvenori inhibit rat intestinal maltase and suppress the rise in blood glucose level after a single oral administration of maltose in rats
Suzuki YA, Murata Y, Inui H, Sugiura M, and Nakano Y.
[J. Agric. Food Chem., 53, 2941-2946, 2005]

4. Molecular characterization of a bifunctional glyoxylate cycle enzyme, malate synthase/isocitrate lyase, in Euglena gracilis
Nakazawa M, Minami T, Teramura K, Kumamoto S, Hanato S, Takenaka S, Ueda M, Inui H, Nakano Y, and Miyatake K.
[Comp. Biochem. Physiol. B, 141, 445-452, 2005]

2004

1. Hypoxic up-regulation of triosephosphate isomerase expression in mouse brain capillary endothelial cells
Yamaji R, Fujita K, Nakanishi I, Nagao K, Naito M, Tsuruo T, Inui H, and Nakano Y.
[Arch. Biochem. Biophys., 432, 332-342, 2004]

2. Characterization of corrinoid compounds from a Japanese black tea (Batabata-cha) fermented by bacteria
Kittaka-Katsura H, Ebara S, Watanabe F, and Nakano Y.
[J. Agric. Food Chem., 52, 909-911, 2004]

3. Purification and characterization of methylmalonyl-CoA mutase from a photosynthetic coccolithophorid alga, Pleurochrysis carterae
Miyamoto E, Watanabe F, Yamaguchi Y, Takenaka H, and Nakano Y.
[Comp. Biochem. Physiol. B, 138, 163-167, 2004]

4. Effect of carotenoids and ascorbic acid of Japanese persimmons on cellular lipid peroxidation in HepG2 cells
Hosotani K, Kawahata A, Koyama K, Murakami C, Yoshida H, Yamaji R, Inui H, and Nakano Y.
[Biofactors, 21, 241-245, 2004]

5. Induction and functional analysis of two reduced nicotinamide adenine dinucleotide phosphate-dependent glutathione peroxidase-like proteins in Synechocystis PCC 6803 during the progression of oxidative stress
Gaber A, Yoshimura K, Tamoi M, Takeda T, Nakano Y, and Shigeoka S.
[Plant Physiol., 136, 2855-2861, 2004]

6. Enzymatic high digestion of soybean milk residue (okara)
Kasai N, Murata A, Inui H, Sakamoto T, and Kahn RI.
[J. Agric. Food Chem., 52, 5709-5716, 2004]

2003

1. Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger
Yamaji R, Fujita K, Takahashi S, Yoneda H, Nagao K, Masuda W, Naito M, Tsuruo T, Miyatake K, Inui H, and Nakano Y.
[Biochim. Biophys. Acta - Mol. Cell Res., 1593, 269-276, 2003]

2. Hypoxia-induced megaloblastosis in vitamin B12-deficient rats
Ebara S, Adachi S, Takenaka S, Enomoto T, Watanabe F, Yamaji R, Inui H, and Nakano Y.
[Brit. J. Nutr., 89, 441-444, 2003]

3. Nitric oxide synthase induction, cGMP elevation, and biopterin synthesis in vascular smooth muscle cells stimulated with interleukin-1β in hypoxia
Nagao K, Takanaka S, Yamaji R, Inui H, and Nakano Y.
[J. Biochem., 133, 501-505, 2003]

4. Purification and characterization of homodimeric methylmalonyl-CoA mutase from Sinorhizobium meliloti
Miyamoto E, Watanabe F, Charles TC, Yamaji R, Inui H, and Nakano Y.
[Arch. Microbiol., 180, 151-154, 2003]

5. Presence of glyoxylate cycle enzymes in the mitochondria of Euglena gracilis
Ono K, Kondo M, Osafune T, Miyatake K, Inui H, Kitaoka S, Nishimura M, and Nakano Y.
[J. Eukaryot. Microbiol., 50, 92-96, 2003]

6. Translational regulation of histamine N-methyltransferase
Ogasawara M, Yamauchi K, Yamaji R, and Maeyama, K.
[J. Pharmacol. Sci., 91, 109P Suppl. 1]

7. Effect of UV screens and preservatives on vitellogenin and choriogenin production in male medaka (Oryzias latipes)
Inui M, Adachi T, Takenaka S, Inui H, Nakazawa M, Ueda M, Watanabe H, Mori C, Iguchi T, and Miyatake K.
[Toxicology, 194, 43-50, 2003]  

2002

1. Purification and characterization of a corrinoid compound from chlorella tablets as an algal health food
Kittaka-Katsura H, Fujita T, Watanabe F, and Nakano Y.
[J. Agric. Food Chem., 50, 4994-4997, 2002]

2. Uptake and physiological function of vitamin B12 in a photosynthetic unicellular coccolithophorid alga, Pleurochrysis carterae
Miyamoto Y, Watanabe F, Takenaka H, and Nakano Y.
[Biosci. Biotech. Biochem., 66, 195-198, 2002]

3. Occurrence of a novel NADP+-linked alcohol dehydrogenase in Euglena gracilis
Iqbal M, Nakazawa M, Harano K, Yamaji R, Inui H, Miyatake K, and Nakano Y.
[Comp. Biochem. Physiol., B132, 535-540, 2002]

4. Purification and characterization of Methylmalonyl-CoA mutase from a methanol-utilizing bacterium, Methylobacterium extorquens NR
Miyamoto E, Watanabe F, Yamaji R, Inui H, Sato K, and Nakano Y.
[J. Nutr. Sci. Vitaminol., 48, 242-246, 2002]

5. Effects of epigallocatechin 3-O-gallate on cellular antioxidative system in HepG2 cells
Murakami C, Hirakawa Y, Inui H, Nakano Y, and Yoshida H.
[J. Nutr. Sci. Vitaminol., 48, 89-94, 2002]

6. Effect of tea catechins on cellular lipid peroxidation and cytotoxicity in HepG2 cells.
Murakami C, Hirakawa Y, Inui H, Nakano Y, and Yoshida H.
[Biosci. Biotechnol. Biochem., 66, 1559-1562, 2002] 

2001

1. Inflammatory responses to lipopolysaccharide are suppressed in 40% energy-restricted mice
Matsuzaki J, Kuwamura M, Yamaji R, Inui H, and Nakano Y.
[J. Nutr., 131, 2139-2144, 2001]

2. Cobalamin deficiency results in severe metabolic disorder of serine and threonine in rats
Ebara S, Toyoshima T, Matsumura T, Adachi S, Takenaka S, Yamaji R, Watanabe F, Miyatake K, Inui H, and Nakano Y.
[Biochim. Biophys. Acta - Gen. Subjects, 1568, 111-117, 2001]

3. Characterization of a Vitamin B12 Compound from Unicellular Coccolithophorid Alga (Pleurochrysis carterae)
Miyamoto E, Watanabe F, Ebara S, Takenaka S, Takenaka H, Yamaguchi Y, Tanaka N, Inui H, and Nakano Y.
[J. Agric. Food Chem., 49, 3486-3489, 2001]

4. Inactive corrinoid-compound significantly decreases in spirulina platensis grown in a cobalt-deficient medium
Watanabe F, Miyamoto E, and Nakano Y.
[J. Agric. Food Chem., 49, 5685-5688, 2001]

5. Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status
Takenaka S, Sugiyama S, Ebara S, Miyamoto E, Abe K, Tamura Y, Watanabe F, Tsuyama S, and Nakano Y.
[Brit. J. Nutr., 85, 699-703, 2001]

6. Characterization of a vitamin B12 compounds from edible shellfish, clam, oyster, and mussel
Watanabe F, Katsura H, Takenaka S, Enomoto T, Miyamoto E, Nakatsuka T, and Nakano Y.
[Int. J. Food Sci. Nutr., 52, 263-268, 2001]

7. Improvement of the flavor of canned satsuma mandarin with the essence
Takahashi H, Sumitani H, Inada Y, Mori D, and Nakano Y.
[Appl. Biol. Sci., 7, 49-56, 2001]

8. Characterization of monoclonal antibodies against ascorbate peroxidase isoenzymes: purification and epitope-mapping using immunoaffinity column chromatography
Yoshimura K, Ishikawa T, Wada K, Takeda T, Kamata Y, Tada T, Nishimura K, Nakano Y, and Shigeoka S.
[Biochim. Biophys. Acta - Gen. Subjects, 1526, 168-174, 2001]

9. NADPH-dependent glutathione peroxidase-like proteins (Gpx-1, Gpx-2) reduce unsaturated fatty acid hydroperoxides in Synechocystis PCC 6803
Gaber A, Tamoi M, Takeda T, Nakano Y, and Shigeoka S.
[FEBS Lett., 499, 32-36, 2001]

10. Expression of a gene encoding chitinase (pCA8ORF) from Aeromonas sp. No. 10S-24 in Escherichia coli enzyme characterization
Sutrisno A, Ueda M, Inui H, Kawaguchi T, Nakano Y, Arai M, and Miyatake K.
[J. Biosci. Bioeng., 91, 599-602, 2001]

11. Effect of barley on gastric juice secretion in rats with water immersion induced stress ulcer
Yoshizawa M, Nakano Y, and Nakamura H.
[J. Assoc. Dietary Fiber Res., 5, 21-27, 2001]

12. ビタミン研究のブレークスルー:「ナイアシン」(4)ナイアシン化合物の新規な生理作用
中野長久.
[ビタミン, 75, 87-94, 2001]

13. ビタミンB12の食品学的研究
渡辺文雄、宮本恵美、中野長久.
[New Food Industry, 43, 49-56, 2001]

14. インターフェロンを体内で作る力は食事を腹八分にするだけでも強くなる
中野長久.
[わかさ, 6, 16-17, 2001]

2000

1. Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex
Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, and Vaughan M.
[Proc. Natl. Acad. Sci. USA, 97, 2567-2572, 2000]

2. Implanted tumor growth is suppressed and survival is prolonged in sixty percent of food-restricted mice
Matsuzaki J, Yamaji R, Kiyomiya K, Kurebe M, Inui H, and Nakano Y.
[J. Nutr., 130, 111-115, 2000]

3. Increases in gastric histidine decarboxylase activity and plasma gastrin level in streptozotocin- induced type 1 diabetic rats
Inui H, Yasuno R, Takenoshita M, Ohnishi Y, Sakamoto M, Matsuzaki J, Yamaji R, Miyatake K, Yamatodani A, and Nakano Y.
[J. Nutr. Sci. Vitaminol., 46, 144-148, 2000]

4. Characterization of a vitamin B12 compound in the edible purple laver, Porphyra yezoensis
Watanabe F, Takenaka S, Katsura H, Miyamoto E, Abe K, Tamura Y, Nakatsuka T, and Nakano Y.
[Biosci. Biotech. Biochem., 64, 2712-2715, 2000]

5. The improvement of the flavor of canned satsuma mandarin
Takahashi H, Sumitani H, Inada Y, Mori D, and Nakano Y.
[Appl. Biol. Sci., 6, 67-73, 2000]

6. Effect of light-induced riboflavin degradation on the loss of cobalamin in milk
Watanabe F, Katsura H, Abe K, and Nakano Y.
[J. Home Econ. Jpn., 51, 231-234, 2000]

7. The origin of pyruvate:NADP+ oxidoreductase in mitochondria of Euglena gracilis
Nakazawa M, Inui H, Yamaji R, Yamamoto T, Takenaka S, Ueda M, Nakano Y, and Miyatake K.
[FEBS Lett., 479, 155-157, 2000]

8. ビワ果実の原料および缶詰製品の香気寄与成分
高橋英史、 隅谷英伸、稲田有美子、 森大蔵、 中野長久.
[日本食品科学工業会誌, 47, 302-310, 2000]

9. 温州ミカン砂じょうの揮発性成分
高橋英史、隅谷英伸、稲田有美子、森大蔵、中野長久.
[日本食品科学工業会誌, 47, 455-459, 2000]

10. ビタミンB12欠乏によるラット精巣の形態学的変化
山川めぐみ、渡辺敏明、渡辺皓、榎原周平、中野長久.
[微量栄養素研究, 17, 75-82, 2000]

1999

1. Disordered expression of the sucrase-isomaltase complex in the small intestine in Otsuka Long-Evans Tokushima fatty rats, a model of non-insulin-dependent diabetes mellitus with insulin resistance
Adachi T, Takenoshita M, Katsura H, Yasuda K, Tsuda K, Seino Y, Enomoto T, Yamaji R, Miyatake K, Inui H, and Nakano Y.
[Biochim. Biophys. Acta - Gen. Subjects, 1426, 126-132, 1999]

2. Purification and characterization of ADP-ribosyl cyclase from Euglena gracilis
Masuda W, Takenaka S, Tsuyama S, Inui H, Miyatake K, and Nakano Y.
[J. Biochem., 125, 449-453, 1999]

3. Dried green and purple lavers (Nori) contain substantial amounts of biologically active vitamin B12 but less of dietary iodine relative to other edible seaweeds
Watanabe F, Takenaka S, Katsura H, Mazumder ZH, Abe K, Tamura Y, and Nakano Y.
[J. Agric. Food Chem., 47, 2341-2343, 1999]

4. Pseudovitamin B12 is the predominant cobamide of an algal health food, spirulina tablets
Watanabe F, Katsura H, Takenaka S, Fujita T, Abe K, Tamura T, Nakatsuka T, and Nakano Y.
[J. Agric. Food Chem., 47, 4736-4741, 1999]

5. 特集:臨床ビタミン学、ビタミンB1、基礎的事項~化学構造、生理作用、代謝~
乾博、中野長久.
[日本臨床, 57, 25-30, 1999]

6. 特集:臨床ビタミン学、ビタミンB12、基礎的事項~化学構造、生理作用、代謝~
渡辺文雄、中野長久.
[日本臨床, 57, 43-48, 1999]

1998

1. Suppressive effect of insulin on the synthesis of sucrase-isomaltase complex in small intestinal epithelial cells, and abnormal increase in the complex under diabetic conditions
Takenoshita M, Yamaji R, Inui H, Miyatake K, and Nakano Y.
[Biochem. J., 329, 597-600, 1998]

2. The intron 5-inserted form of rat erythropoietin receptor is expressed as a membrane-bound form
Yamaji R, Murakami C, Takenoshita M, Tsuyama S, Inui H, Miyatake K, and Nakano Y.
[Biochim. Biophys. Acta - Mol. Cell Res., 1403, 169-178, 1998]

3. Effect of microwave heating on the loss of vitamin B12 in foods
Watanabe F, Abe K, Fujita T, Goto M, Hiemoti M, and Nakano Y.
[J. Agric. Food Chem., 46, 206-210, 1998]

4. Comparison of microbiological assay and a fully automated chemiluminescent system for the determination of vitamin B12 in food
Watanabe F, Takenaka S, Abe K, Tamura Y, and Nakano Y.
[J. Agric. Food Chem., 46, 1433-1436, 1998]

5. Biological activity of hydroxo-vitamin B12 degradation product formed during microwave heating
Watanabe F, Abe K, Katsura H, Takenaka S, Mazumder ZH, Yamaji R, Ebara S, Fujita T, Tanimori S, Kirihata M, and Nakano Y.
[J. Agric. Food Chem., 46, 5177-5180, 1998]

6. α2-Adrenoceptor-mediated antisecretory effect of hypoxia in conscious rats
Yamaji R, Ohnishi Y, Sakamoto M, Takenoshita M, Ohta M, Tsuyama S, Watanabe F, Inui H, Miyatake K, and Nakano Y.
[Biosci. Biotech. Biochem., 62, 546-549, 1998]

7. Low sucrase activity in the small intestine of a senescence-accelerated strain of mouse, SAMP1
Takenoshita M, Yabune M, Katsura H, Yamaji R, Inui H, Miyatake K, and Nakano Y.
[Biosci. Biotech. Biochem., 62, 965-969, 1998]

8. Suppression by water extracts of sophora plants of sucrose-induced hyperglycemia in rats and inhibition of intestinal disaccharidases in vitro
Shi H, Huang Q, Yamaji R, Inui H, Fujita T, Miyatake K, Nakano Y, Tada T, and Nishimura K.
[Biosci. Biotech. Biochem., 62, 1225-1227, 1998]

9. Occurrence of vitamin B12 coenzymes in an halotolerant green alga, Dunaliella tertiolecta
Watanabe F, Abe K, Katsura H, Takenaka S, Mazumder ZH, Tamura Y, and Nakano Y.
[Appl. Biol. Sci., 4, 17-26, 1998]

10. Propionic acid metabolism in Euglena gracilis Z I. effect of ammonium ion
Mazumder ZH, Inui H, Ueda M, Miyatake K, Haranou K, and Nakano Y.
[Appl. Biol. Sci., 4, 37-46, 1998]

11. Inhibition of aldose reductases by α-and β-glucosides from A Perilla and possible implications for recognition of α-and β-glucoside configuration
Fujita T, Ohira K, Takenoshita M, Nakatsuka T, Yamaji R, Ueda M, Miyatake K, Nakayama M, and Nakano Y.
[Appl. Biol. Sci., 4, 123-134, 1998]

12. Effects of CO2 and O2 concentrations and light intensity on growth of microalgae (Euglena gracilis) in CELSS
Kitaya Y, Kibe S, Oguchi M, Tanaka H, Miyatake K, and Nakano Y.
[Life Support Biosph. Sci., 5, 243-247, 1998]

13. 地球環境を閉鎖・循環型生態系として配慮した食糧生産システム~藻類(ユーグレナ)の食糧資源化に関する研究~
中野長久、宮武和孝、乾博、穂波信雄、村上克介、金井謙二、辰巳雅彦、相賀一郎、近藤次郎.
[CELSS J.,10, 13-23, 1998]

14. NIDDMモデルラット(OLETFラット)における糖質の消化について~二糖類水解酵素~
足達哲也、安田浩一朗、竹之下誠、宮武和孝、中野長久、藤田準、鍵本伸二、山田祐一郎、塚田英昭、石田均、津田謹輔、清野裕
[Ann. Jpn. Soc. Res. Diab. Complicant., 11, 240-247, 1998]

15. 高酸素および低酸素暴露時におけるラット肝臓中のレチノール, β-カロテンおよびα-トコフェロール量の変動
桂博美、松崎順子、中野長久.
[日本家政学会誌, 49, 1217-1222, 1998]

1997

1. Oscillation of ADP-ribosyl cyclase activity during the cell cycle and function of cyclic ADP-ribose in a unicellular organism, Euglena gracilis
Masuda W, Takenaka S, Inageda K, Nishina H, Takahashi K, Katada T, Tsuyama S, Inui H, Miyatake K, and Nakano Y.
[FEBS Lett., 405, 104-106, 1997]

2. Method for quantitation of total vitamin B12 in foods using a highly fluorescent vitamin B12 derivative
Watanabe F, Abe K, Takenaka S, Fujita T, and Nakano Y.
[J. Agric. Food Chem., 45, 4661-4663, 1997]

3. Inositol 1,4,5-trisphosphate and dyclic ADP-ribose mobilize Ca2+ in a protist, Euglena gracilis
Masuda W, Takenaka S, Tsuyama S, Tokunaga M, Yamaji R, Inui H, Miyatake K, and Nakano Y.
[Comp. Biochem. Physiol., 118C, 279-283, 1997]

4. Accumulation of trehalose as a compatible solute under osmotic stress in Euglena gracilis Z
Takenaka S, Kondo T, Nazeri S, Tamura Y, Tokunaga M, Tsuyama S, Miyatake K, and Nakano Y.
[J. Euk. Microbiol., 44, 609-613, 1997]

5. Effect of carnosine and anserine on the destruction of vitamin B12 with vitamin C in the presence of copper
Takenaka S, Sugiyama S, Watanabe F, Abe K, Tamura Y, and Nakano Y.
[Biosci. Biotech. Biochem., 61, 2137-2139, 1997]

6. Occurrence of Cobalamin Coenzymes in the Photosynthetic Green Alga
Watanabe F, Abe K, Takenaka S, Tamura Y, Maruyama I, and Nakano Y.
[Biosci. Biotech. Biochem., 61, 896-897, 1997]

7. Salt-torerant Mechanism of a Protozoan, Eugelana gracilis Z
Nakano Y, Miyatake K, Watanabe F, and Takenaka S.
[Salt Sci. Res. Foundation Ann. Res. Rep., 367-376, 1997]

8. Growth of Euglena, a photosynthetic alga, by light emitting diodes
Aiga I, Kiyota M, Matsumoto T, Yamaji R, Nakano Y, Miyatake K, Takenaka S, Masuda W, Jinda T, Horaguchi K, Wasa K, and Kondo J.
[CELSS J., 9, 7-12, 1997]

9. 実験生ものがたり ミドリムシ~Euglena~
中野長久.
[遺伝, 51, 72-74, 1997]  

1996

1. Brain capillary endothelial cells express two forms of erythropoietinreceptor mRNA
Yamaji R, Okada T, Naito M, Tsuruo T, Miyatake K, and Nakano Y.
[Eur. J. Biochem., 239, 494-500, 1996]

2. Hypoxia inhibits gastric emptying and gastric acid secretion in conscious rats
Yamaji R, Sakamoto M, Miyatake K, Nakano Y.
[J. Nutr., 126, 673-680, 1996]

3. Mitochondrial NADH-linked aquacobalamin reductase activity is low in human skin fibroblasts with defects in synthesis of cobalamin coenzymes
Watanabe F, Saido H, Yamaji R, Miyatake K, Isegawa Y, Ito A, Yubisui T, Rosenblatt DS, and Nakano Y.
[J. Nutr., 126, 2947-2951, 1996]

4. Effect of cobalamin deficiency on the biosynthesis of phosphatidylcholine in Euglena gracilis
Inui H, Ohya O, Isegawa Y, Kitaoka S, Miyatake K, and Nakano Y.
[J. Euk. Microbiol., 43, 177-180, 1996]

5. Accumulation of methylmalonic acid caused by vitamin B12-deficiency disrupts normal cellular metabolism in rat liver
Toyoshima S, Watanabe F, Saido H, Pezacka E, Jakobsen D, Miyatake K, and Nakano Y.
[Brit. J. Nutr., 75, 929-938, 1996]

6. Purification and characterization of arginine: mono-ADP-ribosylhydrolase from Euglena gracilis Z
Takenaka S, Masuda W, Tsuyama S, Tamura Y, Miyatake K, and Nakano Y.
[J. Biochem., 120, 792-796, 1996]

7. Adenosylcobalamin-dependent methylmalonyl-CoA mutase isozymes in the phtosynthetic protozoon Euglena gracilis Z
Watanabe F, Abe K, Tamura Y, and Nakano Y.
[Microbiology, 142, 2631-2634, 1996]

8. Characterization of niacin of skipjack tuna muscle and change of the niacin content during storage
Watanabe F, Goto M, Abe K, Nakano Y.
[J. Jpn. Soc. Cold Preserva. Food, 22, 165-168, 1996]

9. Glutathione peroxidase activity during storage of fish muscle
Watanabe F, Goto M, Abe K, and Nakano Y.
[J. Food Sci., 61, 734-735, 1996]

10. Euglena gracilis fermentative wax ester production
Abe K, Watanabe F, Masuda W, Inui H, Miyatake K, and Nakano Y.
[Appl. Biol. Sci., 2, 33-40, 1996]

11. Different location in dark-adapted leaves of phaseolus vulgaris of ribulose-1,5-bisphosphatecarboxylase/oxygenase and 2-carboxyarabinitol 1-phosphate
Anwaruzzaman, Nakano Y, and Yokota A.
[FEBS Lett., 388, 223-227, 1996]

12. Purification and characterization of serine hydroxymethyltransferase from mitochondria of Euglena gracilis Z
Sakamoto M, Masuda T, Yanagimoto Y, Nakano Y, Kitaoka S, and Tanigawa Y.
[Biosci. Biotech. Biochem., 60, 1941-1944, 1996]

13. Growth of photosynthetic algae Euglena in high CO2 conditions and its photosynthetic characteristics
Nakano Y, Miyatake K, Okuno H, Hamazaki K, Takenaka S, Honami N, Kiyota M, Aiga I, and Kondo J.
[Acta Hort.,440, 49-54, 1996]

14. K project: production of food by biological fixation of CO2
Kondo J, Aiga I, Nakano Y, and Miyatake K.
[Acta Hort., 440, 645-650, 1996]