2026
OPA1 in MC4R Neurons Regulates Dietary Fat Intake and Body Weight in Mice.
Matsumura S, Fujiwara M, Horie S, Marutani M, Nousou E, Iki N, Yamato Y, Otonashi Y, Sasaki T, Fujitani M, Fujikawa T. FASEB J. 2026 May 31;40(10):e71941. doi: 10.1096/fj.202600452R.
Wheat Flour Intake Promotes Weight Gain and Metabolic Changes in Mice.
Matsumura S, Marutani M, Nousou E, Murakami N, Mizobata S, Fujisawa M, Fujiwara M, Iki N, Horie S, Yamato Y, Yamamoto A, Fujitani M, Fujikawa T, Ishibashi C, Takenaka S. Mol Nutr Food Res. 2026 Jan;70(2):e70394. doi: 10.1002/mnfr.70394.
Characterizing stroke-related cellular changes in the surviving neurons of mouse ischemic stroke.
Ikegami T, Sasaki T, Shimbo T, Kitayama T, Yamamoto Y, Ouchi Y, Yamazaki S, Sugiyama S, Nishiyama K, Gon Y, Okazaki S, Todo K, Matsumura S, Tamai K, Mochizuki H. Neurochem Int. 2025 Dec;191:106086. doi: 10.1016/j.neuint.2025.106086. Epub 2025 Nov 11.
MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration.
Sowa N, Horie T, Ide Y, Baba O, Kora K, Yoshida T, Nakamura Y, Matsumura S, Matsushita K, Imanaka M, Zou F, Kume E, Kojima H, Qian Q, Kimura K, Otsuka R, Hara N, Yamasaki T, Otani C, Tsujisaka Y, Takaya T, Nishimura C, Watanabe D, Hasegawa K, Kotera J, Oka K, Fujita R, Takemiya A, Sasaki T, Kasahara Y, Obika S, Kimura T, Ono K. EMBO Mol Med. 2025 Aug;17(8):1902-1925. doi: 10.1038/s44321-025-00273-9. Epub 2025 Jul 23.
Nrf2-and p53-inducible REDD2/DDiT4L/Rtp801L confers pancreatic β-cell dysfunction, leading to glucose intolerance in high-fat diet-fed mice.
Yamada Y, Urakawa N, Tamiya H, Sakamoto S, Takahashi H, Harada N, Kitakaze T, Izawa T, Matsumura S, Yoshihara E, Inui H, Mashimo T, Yamaji R. J Biol Chem. 2025 Jun;301(6):110271. doi: 10.1016/j.jbc.2025.110271. Epub 2025 May 21.
Development and characterization of an Sf-1-Flp mouse model.
Galvan M, Fujitani M, Heaselgrave SR, Thomas S, Chen B, Lee JJ, Wyler SC, Elmquist JK, Fujikawa T. JCI Insight. 2025 Mar 4:e190105. doi: 10.1172/jci.insight.190105.
2024
LCoRL Regulates Growth and Metabolism. Wyler SC, Gahlot S, Bideyan L, Yip C, Dushime J, Chen B, Lee JJ, Tinajero A, Limboy C, Bordash S, Heaselgrave SR, Nguyen TN, Lee S, Bookout A, Lantier L, Fowlkes JL, You YJ, Fujikawa T, Elmquist JK. Endocrinology. 2024 Oct 30;165(12):bqae146.
Modulation of Ca2+ oscillation following ischemia and nicotinic acetylcholine receptors in primary cortical neurons by high-throughput analysis. Sasaki T, Hisada S, Kanki H, Nunomura K, Lin B, Nishiyama K, Kawano T, Matsumura S, Mochizuki H. Sci Rep. 2024 Nov 12;14(1):27667.
Miyamori H, Yokokawa T, Miyakita M, Ozaki K, Goto T, Inoue K, Matsumura S. Diabetes. 2024 Dec 1;73(12):1976-1989. doi: 10.2337/db24-0014.
2023
Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes.
Kwon J, Yeh YS, Kawarasaki S, Minamino H, Fujita Y, Okamatsu-Ogura Y, Takahashi H, Nomura W, Matsumura S, Yu R, Kimura K, Saito M, Inagaki N, Inoue K, Kawada T, Goto T. iScience. 2023 Feb 8;26(3):106161.
2022
Stimulation of Gs signaling in MC4R cells by DREADD increases energy expenditure, suppresses food intake, and increases locomotor activity in mice. Matsumura S, Miyakita M, Miyamori H, Kyo S, Shima D, Yokokawa T, Ishikawa F, Sasaki T, Jinno T, Tanaka J, Goto T, Momma K, Ishihara K, Berdeaux R, Inoue K. Am J Physiol Endocrinol Metab. 2022 May 1;322(5):E436-E445.
CRTC1 deficiency, specifically in melanocortin-4 receptor-expressing cells, induces hyperphagia, obesity, and insulin resistance. Matsumura S, Miyakita M, Miyamori H, Kyo S, Ishikawa F, Sasaki T, Jinno T, Tanaka J, Fujita K, Yokokawa T, Goto T, Momma K, Takenaka S, Inoue K. FASEB J. 2022 Dec;36(12):e22645.
MDMX elevation by a novel Mdmx-p53 interaction inhibitor mitigates neuronal damage after ischemic stroke.
Yan H, Sasaki T, Kanki H, Hirata Y, Nishiyama K, Hisada S, Matsumura S, Nagaoka Y, Sumiyoshi T, Nagano S, Nakata A, Yoshida M, Uesato S, Mochizuki H. Sci Rep. 2022 Dec 6;12(1):21110.
Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin. Harada N, Okuyama M, Teraoka Y, Arahori Y, Shinmori Y, Horiuchi H, Luis PB, Joseph AI, Kitakaze T, Matsumura S, Hira T, Yamamoto N, Iuni T, Goshima N, Schneider C, Inui H, Yamaji R. NPJ Sci Food. 2022 Jan 14;6(1):4.
Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice. Tanaka J, Ishikawa F, Jinno T, Miyakita M, Miyamori H, Sasaki T, Yokokawa T, Goto T, Inoue K, Matsumura S. PLoS One. 2022 Jan 12;17(1):e0262577.
2021
A mouse model of weight gain after nicotine withdrawal. Takeda K, Aotani D, Kuga Y, Jinno T, Guo T, Ogawa K, Shimizu Y, Hattori R, Yagi T, Koyama H, Matsumura S, Kataoka H, Tanaka T. Biochem Biophys Res Commun. 2022 Jan 15;588:140-146. doi: 10.1016/j.bbrc.2021.12.064. Epub 2021 Dec 20.
MiRNA-132/212 regulates tight junction stabilization in blood-brain barrier after stroke. Yan H, Kanki H, Matsumura S, Kawano T, Nishiyama K, Sugiyama S, Takemori H, Mochizuki H, Sasaki T. Cell Death Discov. 2021 Dec 8;7(1):380. doi: 10.1038/s41420-021-00773-w.
Activation of the adipocyte CREB/CRTC pathway in obesity. Yoon YS, Liu W, Van de Velde S, Matsumura S, Wiater E, Huang L, Montminy M. Commun Biol. 2021 Oct 22;4(1):1214.
Loss of CREB Coactivator CRTC1 in SF1 Cells Leads to Hyperphagia and Obesity by High-fat Diet But Not Normal Chow Diet. Matsumura S, Ishikawa F, Sasaki T, Terkelsen MK, Ravnskjaer K, Jinno T, Tanaka J, Goto T, Inoue K. Endocrinology. 2021 Sep 1;162(9):bqab076. doi: 10.1210/endocr/bqab076.
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity. Horie T, Nakao T, Miyasaka Y, Nishino T, Matsumura S, Nakazeki F, Ide Y, Kimura M, Tsuji S, Rodriguez RR, Watanabe T, Yamasaki T, Xu S, Otani C, Miyagawa S, Matsushita K, Sowa N, Omori A, Tanaka J, Nishimura C, Nishiga M, Kuwabara Y, Baba O, Watanabe S, Nishi H, Nakashima Y, Picciotto MR, Inoue H, Watanabe D, Nakamura K, Sasaki T, Kimura T, Ono K. Nat Commun. 2021 Feb 16;12(1):843.
2020
CREB Coactivator CRTC2 Plays a Crucial Role in Endothelial Function. Kanki H, Sasaki T, Matsumura S, Kawano T, Todo K, Okazaki S, Nishiyama K, Takemori H, Mochizuki H. J Neurosci. 2020 Dec 2;40(49):9533-9546.
Food texture affects glucose tolerance by altering pancreatic β-cell function in mice consuming high-fructose corn syrup. Harada N, Nomura M, Yoda Y, Matsumura S, Inui H, Yamaji R. PLoS One. 2020 May 29;15(5):e0233797.
2019
β-arrestin-2 in PAR-1-biased signaling has a crucial role in endothelial function via PDGF-β in stroke. Kanki H, Sasaki T, Matsumura S, Yokawa S, Yukami T, Shimamura M, Sakaguchi M, Furuno T, Suzuki T, Mochizuki H. Cell Death Dis. 2019 Feb 4;10(2):100.
Chronic high corticosterone with voluntary corn oil ingestion induces significant body weight gain in mice. Matsumura S, Odanaka M, Ishikawa F, Sasaki T, Manio MCC, Fushiki T, Inoue K. Physiol Behav. 2019 May 15;204:112-120.
2018
Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine. Hashimoto O, Funaba M, Sekiyama K, Doi S, Shindo D, Satoh R, Itoi H, Oiwa H, Morita M, Suzuki C, Sugiyama M, Yamakawa N, Takada H, Matsumura S, Inoue K, Oyadomari S, Sugino H, Kurisaki A. Cell Rep. 2018 Oct 30;25(5):1193-1203.
Voluntary Corn Oil Ingestion Increases Energy Expenditure and Interscapular UCP1 Expression Through the Sympathetic Nerve in C57BL/6 Mice. Matsumura S, Ishikawa F, Sasaki T, Odanaka M, Manio MCC, Fushiki T, Inoue K. Mol Nutr Food Res. 2018 Nov;62(22):e1800241.
cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis. Yoon YS, Tsai WW, Van de Velde S, Chen Z, Lee KF, Morgan DA, Rahmouni K, Matsumura S, Wiater E, Song Y, Montminy M. Proc Natl Acad Sci U S A. 2018 Jun 5;115(23):E5289-E5297.
2017
Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members. Sonntag T, Moresco JJ, Vaughan JM, Matsumura S, Yates JR 3rd, Montminy M. PLoS One. 2017 Feb 24;12(2):e0173013.
2016
Hepatocyte β-Klotho regulates lipid homeostasis but not body weight in mice.
Kobayashi K, Tanaka T, Okada S, Morimoto Y, Matsumura S, Manio MC, Inoue K, Kimura K, Yagi T, Saito Y, Fushiki T, Inoue H, Matsumoto M, Nabeshima Y. FASEB J. 2016 Feb;30(2):849-62. doi: 10.1096/fj.15-274449. Epub 2015 Oct 29.
2015
Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2.
Hogan MF, Ravnskjaer K, Matsumura S, Huising MO, Hull RL, Kahn SE, Montminy M. J Biol Chem. 2015 Oct 23;290(43):25997-6006. doi: 10.1074/jbc.M115.679266. Epub 2015 Sep 4.
Mechanisms Involved in Guiding the Preference for Fat Emulsion Differ Depending on the Concentration.
Sakamoto K, Matsumura S, Okafuji Y, Eguchi A, Lee S, Adachi S, Fujitani M, Tsuzuki S, Inoue K, Fushiki T. J Nutr Sci Vitaminol (Tokyo). 2015;61(3):247-54. doi: 10.3177/jnsv.61.247.
Lee S, Eguchi A, Tsuzuki S, Matsumura S, Inoue K, Iwanaga T, Masuda D, Yamashita S, Fushiki T. PLoS One. 2015 Jul 17;10(7):e0133412. doi: 10.1371/journal.pone.0133412. eCollection 2015.
Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity.
Ohta H, Konishi M, Kobayashi Y, Kashio A, Mochiyama T, Matsumura S, Inoue K, Fushiki T, Nakao K, Kimura I, Itoh N. Sci Rep. 2015 May 8;5:10049. doi: 10.1038/srep10049.