業績

2025

  • Yasugi M*, Gunji K, Inagaki K, Kuroda M, Ii C. Disinfection effect of ozonated water on SARS-CoV-2 in the presence of salivary proteins. J Hosp Infect. 155:209-215, 2025.  大学プレスリリース
  • Sakurai K, Nishi K, Sekimoto S, Okawaki R, Htay SS, Yasugi M, Miyake M. Inhibitory effects of sucrose palmitic acid ester on the germination-to-outgrowth process of Clostridium perfringens SM101 spores. Int J Food Microbiol. 426:110910, 2025.
  • Toba S, Uemura K, Sanaki T, Kusakabe S, Konishi K, Miki S, Maruyama Y, Iimuro A, ShishidoT, Sasaki M, Orba Y, Hall WW, Sawa H, Sato A. Synergistic antiviral activity of acathepsin B/L inhibitor and a TMPRSS2 inhibitor against SARS-CoV-2 in vitro and in vivo. Virology. 612:110661, 2025.

2024

  • Yasugi M*, Ohta A, Takano K, Yakubo K, Irie M, Miyake M. Serine affects engulfment during the sporulation process in Clostridium perfringens strain SM101. Anaerobe. 90:102914, 2024.  大学プレスリリース
  • Kaku N#, Yasugi M#, Tshibangu-Kabamba E, Wakabayashi Y, Uesaka Y, Nakagama Y, Nogimori T, Yamamoto T, Mbala-Kingebeni P, Ngoyi DM, Adachi E, Kido Y. Multiple-clone infections of Mpox: Insights from a single primary lesion.

    CMI Comm. 1:105042, 2024 (#, contributed equally).

  • Teshima K, Tanaka T, Zhengmao Y, Ikeda K, Matsuzaki T, Shiroma T, Muroya A, Hosoda M, Yasugi M, Komatsu H. Antiviral activity of curcumin and its analogs selected by an artificial intelligence-supported activity prediction system in SARS-CoV-2-infected VeroE6 cells. Nat Prod Res. 38:867-872, 2024.
  • Wada E, Ito C, Shinohara M, Handa S, Maetani M, Yasugi M, Miyake M, Sakamoto T, Yazawa A, and Kamitani S. Prunin laurate derived from natural substances shows antibacterial activity against the periodontal pathogen Porphyromonas gingivalis. Foods. 13: 1917, 2024.
  • Konishi K, Kusakabe S, Kawaguchi N, Shishido T, Ito N, Harada M, Inoue S, Maeda K, Hall WW, Orba Y, Sawa H, Sasaki M, Sato A. β-d-N4-hydroxycytidine, a metabolite of molnupiravir, exhibits in vitro antiviral activity against rabies virus. Antiviral Res. 229:105977, 2024.
  • Sasaki M, Sugi T, Iida S, Hirata Y, Kusakabe S, Konishi K, Itakura Y, Tabata K, Kishimoto M, Kobayashi H, Ariizumi T, Intaruck K, Nobori H, Toba S, Sato A, Matsuno K, Yamagishi J,Suzuki T, Hall WW, Orba Y, Sawa H. Combination therapy with oral antiviral and anti-inflammatory drugs improves the efficacy of delayed treatment in a COVID-19 hamster model. EBio Med. 99:104950, 2024. 

2023

  • Yasugi M*, Nakagama Y, Kaku N, Nitahara Y, Hatanaka N, Yamasaki S, Kido Y. Characteristics of epitope dominance pattern and cross-variant neutralization in 16 SARS-CoV-2 mRNA vaccine sera. Vaccine. 41:6248-54, 2023.  大学プレスリリース
  • Katahira J, Ohmae T, Yasugi M, Sasaki R, Itoh Y, Kohda T, Hieda M, Yokota-Hirai M, Okamoto T, Miyamoto Y. Nsp14 of SARS-CoV-2 inhibits mRNA processing and nuclear export by targeting the nuclear cap-binding complex. Nucleic Acids Res. 51:7602-18, 2023.
  • Yasugi M*, Hatoya S, Motooka D, Kondo D, Akiyoshi H, Horie M, Nakamura S, Shimada T. Genetic and phenotypic analyses of mcr-harboring extended-spectrum beta-lactamase-producing Escherichia coli isolates from companion dogs and cats in Japan. Vet Microbiol. 280:109695, 2023.  大学プレスリリース
  • Nakagama Y, Candray K, Kaku N, Komase Y, Rodriguez-Funes MV, Dominguez R, Tsuchida T, Kunishima H, Nagai E, Adachi E, Ngoyi DM, Yamasue M, Komiya K, Hiramatsu K, Uemura N, Sugiura Y, Yasugi M, Yamagishi Y, Mikamo H, Shiraishi S, Izumo T, Nakagama S, Watanabe C, Nitahara Y, Tshibangu-Kabamba E, Kakeya H, Kido Y. Antibody avidity maturation following recovery from infection or the booster vaccination grants beadth of SARS-CoV-2 neutralizing capacity. J Infect Dis. 227(6):780-787, 2023.
  • Sasaki M, Tabata K, Kishimoto M, Itakura Y, Kobayashi H, Ariizumi T, Uemura K, Toba S, Kusakabe S, Maruyama Y, Iida S, Nakajima N, Suzuki T, Yoshida S, Nobori H, Sanaki T, Kato T, Shishido T, Hall WW, Orba Y, Sato A, Sawa H. S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters. Sci Transl Med. 15:eabq4064, 2023.
  • Uemura K, Nobori H, Sato A*, Toba S, Kusakabe S, Fukao K, Noshi T, Shano S, Baba K, Sato K, Sakuramoto M, Kitade N, Tanioka H, Sasaki M, Tabata K, Matsuno K, Maeda N, Ito S, Tanaka M, Anraku Y, Kita S, Ishii M, Kanamitsu K, Orba Y, Matsuura Y, Hall WW, Sawa H, Kida H, Matsuda A*, Maenaka K. 2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive strand RNA viruses. Proc Natl Acad Sci U S A. 120:e2304139120, 2023.
  • Fukao K, Noshi T, Shano S, Baba K, Sato K, Sakuramoto M, Kitade N, Tanioka H, Kusakabe S, Shishido T. Prophylactic treatment with baloxavir protects mice from lethal infection with influenza A and B viruses. Viruses. 15:2264, 2023.

2022

  • Yasugi M*, Komura Y, Ishigami Y. Mechanisms underlying inactivation of SARS-CoV-2 by nano-sized electrostatic atomized water particles. J Nanopart Res. 24:1-14, 2022.  大学プレスリリース
  • Hatanaka N, Awasthi SP, Xu B, Goda H, Kawata H, Horiuchi I, Yasugi M, Yamasaki S. Comparative evaluation of chlorous acid and sodium hypochlorite activity against SARS-CoV-2. Access Microbiol. 4:000354, 2022.
  • Komatsu H, Tanaka T, Ye Z, Ikeda K, Matsuzaki T, Yasugi M, Hosoda M. Identification of SARS-CoV-2 main protease inhibitors from FDA-approved drugs by artificial intelligence-supported activity prediction system. J Biomol Struct Dyn. 5:1-9, 2022.
  • Wakabayashi Y, Takemoto K, Iwasaki S, Yajima T, Kido A, Yamauchi A, Kuroiwa K, Kumai Y, Yoshihara S, Tokumoto H, Kawatsu K, Yasugi M, Miyake M. Isolation and characterization of Staphylococcus argenteus strains from retail foods and slaughterhouses in Japan. Int J Food Microbiol. 363:109503, 2022.
  • Hatanaka N, Xu B, Yamashita Y, Kawakami H, Yasugi M, Yamasaki S. Shellcoat, a calcinated calcium solution, effectively inactivates SARS-CoV-2. Bio Sci. 27:53-56, 2022.
  • Ishimoto K, Hatanaka N, Otani S, Maeda S, Xu B, Yasugi M, Moore JE, Suzuki M, Nakagawa S, Yamasaki S. Tea crude extracts effectively inactivate severe acute respiratory syndrome coronavirus 2. Lett Appl Microbiol. 74:2-7, 2022.
  • Taba S, Sato A, Kawai M, Taoda Y, Unoh Y, Kusakabe S, Nobori H, Uehara S, Uemura K, Taniguchi K, Kobayashi M, Noshi T, Yoshida R, Naito A, Shishido T, Maruyama J, Paessler S, Carr MJ, Hall WW, Yoshimatsu K, Arikawa J, Matsuno K, Sakoda Y, Sasaki M, Orba Y, Sawa H, Kida H. Identication of cap-dependent endonuclease inhibitors with broad-spectrum activity against bunyaviruses. Proc Natl Acad Sci U S A. 19:e2206104119, 2022.

2021

  • Takakuwa T, Nakagama Y, Yasugi M, Maeda T, Matsuo K, Kiritoshi A, Deguchi R, Hagawa N, Shibata W, Oshima K, Yamamoto K, Uchida K, Noda T, Yamada K, Nishimura T, Yamamoto H, Kido Y, Hino M, Kakeya H, Mizobata Y. Discrepant antigen-specific antibody responses causing SARS-CoV-2 persistance in a patient receiving B-cell-targeted therapy with rituximab. Intern Med. 60:3827-31, 2021.
  • Nitahara Y, Nakagama Y, Kaku N, Candray K, Michimuko Y, Tshibangu-Kabamba E, Kaneko A, Yamamoto H, Mizobata Y, Kakeya H, Yasugi M, Kido Y. High-resolution linear epitope mapping of the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 mRNA vaccine recipients. Microbiol Spectr. 9:e0096521, 2021.
  • Hatanaka N, Xu B, Yasugi M, Morino H, Tagishi H, Miura T, Shibata T, Yamasaki S. Chlorine dioxide is a more potentantiviral agent against SARS-CoV-2 than sodium hypochlorite. J Hosp Infect. 118:20-26, 2021.
  • Hatanaka N, Yasugi M, Sato T, Mukamoto M, Yamasaki S. Hypochlorous acid solution is a potent antiviral agent against SARS-CoV-2. J Appl Microbiol. 132:1496-1502, 2021.
  • 國武広一郎,村上拡,佃一訓,小崎俊司,安木真世. 低濃度エタノールと界面活性剤の併用による新型コロナウイルスに対する不活化効果. 日本食品微生物学会雑誌. 38:93-97, 2021.
  • 安木真世*,黒田真未,井千尋. 低濃度の有機物存在下におけるオゾン水の新型コロナウイルスに対する不活化効果. 室内環境学会誌. 24:13-18, 2021.
  • Yasugi M*, Hatoya S, Motooka D, Matsumoto Y, Shimamura S, Tani H, Furuya M, Mie K, Miyake M, Nakamura S, Shimada T. Whole-genome analyses of extended-spectrum or AmpC beta-lactamase-producing Escherichia coli isolates from companion dogs in Japan. Plos One. 16:e0246482, 2021.

2020

  • 安木真世*,小村泰浩,石上陽平. 帯電微粒子水の新型コロナウイルスに対する不活化効果. 室内環境学会誌. 23:241-246, 2020.
  • Yasugi M*, Motooka D, Nakamura S, Miyake M. Phosphorothioation of foreign DNA influences the transformation efficiency in Clostridium perfringens NCTC8239, Anaerobe. 61:1-9, 2020.

2019

  • Kanegi R, Yasugi M, Nabetani T, Tanaka T, Wada Y, Hirai K, Sugiura K, Hatoya S*. Clinical findings and treatment of disseminated ‘Mycobacterium avium subspecies hominissuis’ hominissuis infection in a domestic cat. J Vet Med Sci. 81:1842-1849, 2019.
  • Wakabayashi Y, Nariya H, Yasugi M, Kuwahara T, Sarker MR, Miyake M. An enhanced green fluorescence protein (EGFP)-based reporter assay for quantitative detection of sporulation in Clostridium perfringens SM101. Int J Food Microbiol. 291:144-50, 2019.
  • Kusakabe S, Suzuki T, Sugiyama Y, Haga S, Horike K, Tokunaga M, Hirano J, Zhang H, Chen DV, Ishiga H, Komoda Y, Ono C, Fukuhara T, Yamamoto M, Ikawa M, Satoh T, Akira S, Tanaka T, Moriishi K, Fukai M, Taketomi A, Yoshio S, Kanto T, Suzuki T, Okamoto T, Matsuura Y. USP15 participates in hepatitis C virus propagation through regulation of viral RNA translation and lipid droplet formation. J Virol. 93:e01708-18, 2019.

2018

  • Sakanoue H, Yasugi M, Miyake M. Effect of sublethal heat treatment on the later stage of germination-to-outgrowth of Clostridium perfringens spores. Microbiol Immunol. 62:418-24, 2018.
  • Sakanoue H, Nakano T, Sano K, Yasugi M, Monma C, Miyake M. Adherence of Clostridium perfringens spores to human intestinal epithelial Caco-2 cells. FEMS Microbiol Lett. 365, 2018.

  • Suzuki T, Okamoto T, Katoh H, Sugiyama Y, Kusakabe S, Tokunaga M, Hirano J, Miyata Y, Fukuhara T, Ikawa M, Satoh T, Yoshio S, Suzuki R, Saijo M, Huang DCS, Kanto T, Akira S, Matsuura Y. Infection with flaviviruses requires BCLXL for cell survival. PLoS Pathog. 14:e1007299, 2018.

2017

  • Hirano J, Okamoto T, Sugiyama Y, Suzuki T, Kusakabe S, Tokunaga M, FUkuhara T, Sasai M, Tougan T, Matsunaga Y, Yamashita K, Sakai Y, Yamamoto M, Horii T, Standley DM, Moriishi K, Moriya K, Koike K, Matsuura Y. Characterization of SPP inhibitors suppressing propagation of HCV and protozoa. Proc Natl Acad Sci U S A. 114:E10782-E10791, 2017.

2016

  • Yasugi M*, Otsuka K, Miyake M. Nitrate salts suppress sporulation and production of enterotoxin in Clostridium perfringens strain NCTC8239. Microbiol Immunol. 60:657-68, 2016.
  • Misaki R, Fukura N, Kajiura H, Yasugi M, Kubota-Koketsu R, Sasaki T, Momota M, Ono K, Ohashi T, Ikuta K, Fujiyama K. Recombinant production and characterization of human anti-influenza virus monoclonal antibodies identified from hybridomas fused with human lymphocytes. Biologicals. 44:394-402, 2016.
  • Yasugi M*, Okuzaki D, Kuwana R, Takamatsu H, Fujita M, Sarker MR, Miyake M. Transcriptional profile during deoxycholate-induced sporulation in a Clostridium perfringens isolate causing foodborne illness. Appl Environ Microbiol. 82:2929-42, 2016.

  • Kouwaki T, Okamoto T, Ito A, Sugiyama Y, Yamashita K, Suzuki T, Kusakabe S, Hirano J, Fukuhara T, Yamashita A, Saito K, Okuzaki D, Watashi K, Sugiyama M, Yoshio S, Standley DM, Kanto T, Mizokami M, Moriishi K, Matsuura Y. Hepatocyte factor JMJD5 regulates hepatisi B virus replication through interaction with HBx. J Virol. 90:3530-42, 2016.

2015

  • Yasugi M*, Sugahara Y, Hoshi H, Kondo K, Talukdar PK, Sarker MR, Yamamoto S, Kamata Y, Miyake M. In vitro cytotoxicity induced by Clostridium perfringens isolate carrying a chromosomal cpe gene is exclusively dependent on sporulation and enterotoxin production. Microbial Pathog. 85:1-10, 2015.
  • Nakamura S, Horie M, Daidoji T, Honda T, Yasugi M, Kuno A, Komori T, Okuzaki D, Narimatsu H, Nakaya T, Tomonoga T. Influenza A virus-induced expression of a GalNAc transferase, GALNT3, via microRNAs is required for enhanced viral replicaion. J Virol. 90:1788-1801, 2015.
  • Daidoji T, Watanabe Y, Ibrahim MS, Yasugi M, Maruyama H, Masuda T, Arai F, Ohba T, Honda A, Ikuta K, Nakaya T. Avian influenza virus infection of immortalized human respiratory epithelial cells depends upon a delicate balance between hemagglutinin acid stability and endosomal pH. J Biol Chem. 290:10627-42, 2015.

2014

  • Boonsathorn N, Panthong S, Koksunan S, Chittaganpitch M, Phuygun S, Waicharoen S, Prachasupap A, Sasaki T, Kubota-Koketsu R, Yasugi M, Ono K, Arai Y, Kurosu T, Sawanpanyalert P, Ikuta K, Watanabe Y. A human monoclonal antibody derived from a vaccinated volunteer recognizes heterosubtypically a novel epitope on the hemagglutinin globular head of H1 and H9 influenza A viruses. Biochem BiophysRes Comm. 452:865-870, 2014.
  • Pan Y, Sasaki T, Kubota-Koketsu R, Inoue Y, Yasugi M, Yamashita A, Ramadhany R, Arai Y, Du A, Boonsathorn N, Ibrahim MS, Daidoji T, Nakaya T, Ono K, Okuno Y, Ikuta K, Watanabe Y. Human monoclonal antibodies derived from a patient infected with 2009 pandemic influenza A virus broadly cross-neutralize group 1 influenza viruses. Biochem BiophysRes Comm. 450:42-48, 2014.

2013

  • Yasugi M, Kubota-Koketsu R, Yamashita A, Kawashita N, Du A, Misaki R, Kuhara M, Boonsathorn N, Fujiyama K, Okuno Y, Nakaya T, Ikuta K. Emerging antigenic variants at the antigenic site Sb in pandemic A(H1N1)2009 influenza virus in Japan detected by a human monoclonal antibody. Plos One. 8:e77892, 2013.
  • Yasugi M, Kubota-koketsu R, Yamashita A, Kawashita N, Du A, Sasaki T, Nishimura M, Misaki R, Kuhara M, Boonsathorn N, Fujiyama K, Okuno Y, Nakaya T, Ikuta K. Human monoclonal antibodies broadly neutralizing against influenza B virus. Plos Pathog. 9:e1003150, 2013.

2012

  • Ramadhany R, Yasugi M, Nakamura S, Daidoji T, Watanabe Y, Takahashi K, Ikuta K, Nakaya T. Tropism of pandemic 2009 H1N1 influenza A virus. Front Microbiol. 3:128, 2012.
  • Yasugi M, Nakamura S, Daidoji T, Kawashita N, Ramadhany R, Yang CS, Yasunaga T, Iida T, Horii T, Ikuta K, Takahashi K, Nakaya T. Frequency of D222G and Q223R hemagglutinin mutants of pandemic (H1N1) 2009 influenza virus in Japan between 2009 and 2010. Plos One. 7:e30946, 2012.

2010

  • Ueda (Yasugi) M, Daidoji T, Du A, Yang CS, Ibrahim MS, Ikuta K, Nakaya T. Highly pathogenic H5N1 avian influenza virus induces extracellular Ca2+ influx, leading to apoptosis in avian cells. J Virol. 84:3068-3078, 2010.

2009

  • Nakamura S, Yang CS, Sakon N, Ueda (Yasugi) M, Tougan T, Yamashita A, Goto N, Takahashi K, Yasunaga T, Ikuta K, Mizutani T, Okamoto Y, Tagami M, Morita R, Maeda N, Kawai J, Hayashizaki Y, Nagai Y, Horii T, Iida T, Nakaya T. Direct metagenomic detection of viral pathogens in nasal and fecal specimens using an unbiased high-throughput sequencing approach. Plos One. 4:e4219, 2009.

2008

  • Du A, Daidoji T, Koma T, Ibrahim MS, Nakamura S, de Silva UC, Ueda (Yasugi) M, Yang CS, Yasunaga T, Ikuta K, Nakaya T. Detection of circulating Asian H5N1 viruses by a newly established monoclonal antibody. Biochem Biophys Res Comm. 378:197-202, 2008.
  • Daidoji T, Koma T, Du A, Yang CS, Ueda (Yasugi) M, Ikuta K, Nakaya T. H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cells. J Virol. 82:11294-11307, 2008.
  • Ueda (Yasugi) M, Yamate M, Du A, Daidoji T, Okuno Y, Ikuta K, Nakaya T. Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus. Virus Res. 136:91-97, 2008.