Research News

May 26, 2023

  • Human Life and Ecology

How eating natto might help to distress

Eating fermented foods might be the secret to a healthy and long-lived society

Routes of antimicrobial-resistant bacteria transmission

Bacillus subtilis var. natto (Miyagino strain) extends the life span of Caenorhabditis elegans through biological pathways related to innate immunity and longevity, and partially improves stress tolerance

Health is wealth as the saying goes and new research now shows that it is possible to have a healthy, less stressed society through familiar and inexpensive foods. One such food might be the Japanese natto which is made from softened soybeans that have been boiled or steamed and fermented with a bacteria called Bacillus subtilis var. natto. Bacillus subtilis var. natto is found in soil, plants, animals, and the human stomach and intestines. Most of the natto consumed in Japan is made from the Miyagino strain.

A research group led by Professor Eriko Kage-Nakadai at the Graduate School of Human Life and Ecology, Osaka Metropolitan University, examined the effects of Bacillus subtilis var. natto consumption on the lifespan of the host using Caenorhabditis elegans worms. The researchers found that Caenorhabditis elegans fed Bacillus subtilis var. natto had a significantly longer lifespan than those fed the standard diet, and further elucidated that the p38 MAPK pathway and insulin/IGF-1-like signaling pathway, which are known to be involved in innate immunity and lifespan, were involved in the lifespan-enhancing effects of Bacillus subtilis var. natto. They also examined stress tolerance, which has been shown to have a correlation with longevity, and found that resistance to UV light and oxidative stress is enhanced.

Professor Nakadai concluded, "For the first time, we were able to demonstrate the possibility of lifespan-extending effects of Caenorhabditis elegans through the ingestion of Bacillus subtilis var. natto. We hope that future experiments on mammals and epidemiological studies will help to realize a healthy and longer-living society if we can apply this research to humans.”

The research results were published online in the Journal of Applied Microbiology on April 20, 2023.


This work was partially supported by the 4th Natto Research Bounty from Japan natto cooperative society federation.

Paper Information

Journal: Journal of Applied Microbiology
Title: Impacts of Bacillus subtilis var. natto on the lifespan and stress resistance of Caenorhabditis elegans
DOI: 10.1093/jambio/lxad082
Author: Nao Teramoto, Kanae Sato, Takayuki Wada, Yoshikazu Nishikawa, Eriko Kage-Nakadai
Publish: April 20, 2023


Graduate School of Human Life Science
Eriko Kage-Nakadai
E-mail: nakadai[at]
*Please change [at] to @.


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