Research News

Jul 2, 2024

  • Medicine

Safer, swifter, smaller scar: new brain surgery approach targets difficult tumors at skull base

Results compare favorably with conventional microscopic method, with added benefit of shorter operative times, less blood loss

Diagram of skin incision and extent of craniotomy

New endoscopic neurosurgery approach does not require a large craniotomy, so the result is a smaller scar.

Credit: Osaka Metropolitan University


Tumors arising in the base of the skull are among the most difficult to remove in neurosurgery. The current treatment method is to perform surgical removal by what is known as the microscopic anterior transpetrosal approach (ATPA). Seeking to lessen the risk of damage and postoperative complications, as the skull base is densely packed with nerves, blood vessels, and other tissues, not to mention the brain stem, an Osaka Metropolitan University medical research team is taking a new approach.

Led by Dr. Hiroki Morisako, a lecturer in the Graduate School of Medicine’s Department of Neurosurgery, and Professor Takeo Goto, who heads the department, the team has developed a minimally invasive surgical technique called a purely endoscopic subtemporal keyhole ATPA. The team members write in The Journal of Neurosurgery that this is, to their knowledge, the first time this procedure to remove lesions in the skull base region known as the petrous apex has been described in an article.

The endoscopic technique means a smaller area of the skull needs to be surgically opened compared to the microscopic approach, an average of only 11.2 cm² versus 33.9 cm². The risk of damage to the brain is also reduced.

The team performed 10 neurosurgeries using their method from 2022 to 2023 at Osaka Metropolitan University Hospital and compared the results to 13 surgeries using the microscopic ATPA from 2014 to 2021. In terms of operative time, the endoscopic approach reduced it noticeably, from an average of 410.9 minutes to 252.9 minutes. Similarly, blood loss lessened from a mean of 193 ml to 90 ml. The degree of tumor resection (surgical removal) was just as high as the microscopic method, while neurological functions were preserved at a rate equal to or higher than with the conventional approach.

“Comparison of the new endoscopic method and the conventional microscopic method showed no significant difference in tumor resection rate or in the ability to perform daily activities before and after surgery, with the new endoscopic approach resulting in shorter operative times and less blood loss,” Professor Goto stated. “The widespread use of this surgical procedure is expected to improve the treatment results of brain tumors in the base of the skull, not only in Japan but also worldwide.”

Paper information

Journal: Journal of Neurosurgery
Title:Purely endoscopic subtemporal keyhole anterior transpetrosal approach to access the petrous apex region: surgical techniques and early results
DOI: 10.3171/2024.1.JNS231774
Authors: Hiroki Morisako, Tsuyoshi Sasaki, Masaki Ikegami, Yuta Tanoue, Hiroki Ohata, Sachin Ranganatha Goudihalli, Juan Carlos Fernandez-Miranda, Kenji Ohata, Takeo Goto
Published: 5 April 2024


Takeo Goto

Graduate School of Medicine
Email: gotot[at]

*Please change [at] to @.


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