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Human clinical trials reveal anti-obesity and heart-protective effects of black cumin

The black cumin extract used in the trial

Black cumin seeds were shown to improve cholesterol levels in a medical trial led by an Osaka Metropolitan University team.

Credit: Osaka Metropolitan University

Nigella sativa (black cumin), the spice that boosts the flavor of curries like korma and paneer also has another use: its seeds have long been used as a medicinal plant in traditional medicine for their antioxidant and anti-inflammatory effects. Now, a clinical trial led by Osaka Metropolitan University suggests that they also have anti-obesity benefits.

To investigate these effects, a team led by Associate Professor Akiko Kojima-Yuasa of the Graduate School of Human Life and Ecology used cellular experiments and human clinical trials.

In the human clinical trial, participants who consumed 5g of black cumin seed powder daily—roughly a tablespoon—for 8 weeks showed significant reductions in blood triglycerides, LDL (‘bad’) cholesterol, and total cholesterol levels. In addition, HDL (‘good’) cholesterol levels increased. 

Improvements in blood lipid profiles like these are associated with a lower risk of heart problems and premature death.

The group also performed cellular experiments to understand the processes involved. They found that black cumin seed extract inhibited adipogenesis—the formation and maturation of fat cells—by blocking both fat droplet accumulation and the differentiation process.

“This study strongly suggests that black cumin seeds are useful as a functional food for preventing obesity and lifestyle-related diseases,” Professor Kojima-Yuasa said. “It was so gratifying to see black cumin comprehensively demonstrate actual, demonstrable blood lipid-lowering effects in a human trial.”

“We hope to perform longer-term and larger-scale clinical trials to investigate the effects of black cumin on metabolism,” she added. “We are particularly interested in investigating its effects on insulin resistance in diabetes and inflammatory markers.”

Paper information

Journal: Food Science & Nutrition
Title: Black Cumin Seed (Nigella sativa) Confers Anti‐Adipogenic Effects in 3T3‐L1 Cellular Model and Lipid‐Lowering Properties in Human Subjects
DOI: 10.1002/fsn3.70888
Authors: Shamima Ahmed, Mohammad Shaokat Ali, Yuki Nishigaki, Ranita Das, Sumsuddin Ahmed Shiblu, Sharmin Akter, Isao Matsui‐Yuasa, Akiko Kojima‐Yuasa
Published: 1 September 2025
URL: https://doi.org/10.1002/fsn3.70888

Contact

Akiko Kojima-Yuasa
Graduate School of Human Life and Ecology
Email: kojima-yuasa[at]omu.ac.jp

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