Research News

Dec 13, 2023

  • Human Life and Ecology

Graduate School of Human Life and Ecology research featured on the cover of “Chemical Research in Toxicology”

The paper titled “Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1,” authored by a team of researchers led by Professor Shigeo Takenaka of the Graduate School of Human Life and Ecology, has been selected as the cover of the ACS Journal, Chemical Research in Toxicology.

In this study, the researchers elucidated the molecular mechanisms and processes by which the major flavonoids, naringenin, apigenin, and genistein, are metabolized in the body. Molecular docking simulations revealed that the molecular mechanism uncovered in this study is similar to the binding mode in plants.


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Paper information



Japanese article


Graduate School of Human Life and Ecology
Shigeo Takenaka
E-mail takenaka[at]

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